Dosage form
The drug can be produced in two forms - tablets and injection.
Biconvex, round tablets, with an orange or greenish tint. On each side of the tablet is a “spa” label.
Structure:
The main substance:
- drotaverine hydrochloride - 40 mg (in 1 table.).
Excipients:
- corn starch;
- magnesium stearate;
- lactose monohydrate;
- polyvidone.
No-spa in ampoules. The instruction says that the solution of the drug can be intended for both intramuscular and intravenous infusions. The solution is greenish-yellow, transparent.
Structure:
The main substance:
- drotaverine hydrochloride - 20/40 mg (in 1 ml or in 1 ampoule, respectively).
Excipients:
- ethanol 96%;
- sodium metabisulfite;
- water for injections.
Pharmacological action of the drug "No-spa"
The instruction says that no-shpa is a myotropic antispasmodic. The main active ingredient, drotaverine, is a derivative of isoquinolone and exhibits an antispasmodic effect on smooth muscle, which is achieved by inhibiting phosphodiesterase 4. Inhibition of this enzyme can lead to an increase in cAMP in the blood, which can inactivate the myosin kinase chain. It is the latter that leads to smooth muscle relaxation.
The enzyme that hydrolyzes cAMP in smooth muscle cells of the myocardium and blood vessels is an isoenzyme of phosphodiesterase 3 - this shows a rather high efficiency of the drug as an antispasmodic, because when it is used, there is no pronounced effect on CVS, as well as undesirable cardiovascular phenomena.
No-spa is effective for smooth muscle spasms of both muscular and nervous etiology. In addition, regardless of the type of autonomic innervation, the drug can act on the smooth muscle structure of the biliary tract, gastrointestinal tract, vascular and genitourinary systems. No-spa can also improve blood circulation to tissues, due to its vasodilating effect.
No-shpa - testimony
It is used as the main remedy for the following diseases:
- cholecystitis;
- cholelithiasis;
- pericholecystitis;
- cholangitis;
- papillitis;
- cystitis;
- pyelitis;
- bladder tenesmus;
- as well as to increase the rate of cervical dilatation.
It is used as an adjunct in the following diseases:
- gastritis;
- spasms of the cardia;
- pyloric cramps;
- colitis;
- enterocolitis;
- stomach ulcers;
- duodenal ulcers;
- dysmenorrhea;
- headaches;
- strong labor pains.
Side effects of the drug no-spa
The instruction describes all possible side effects in relation to various systems and organs.
Possible side effects from the use of the drug from the gastrointestinal tract:
Possible side effects from the use of the drug from the central nervous system:
- insomnia;
- Dizziness
- headache.
Possible side effects from the use of the drug by the CCC:
- arterial hypertension;
- tachycardia.
Other side effects:
- allergic reactions to components are possible.
Contraindications to the drug but shpa
The instruction describes the following types of contraindications:
- liver or kidney failure;
- heart failure;
- age up to 1 year;
- sensitivity to drotaverine or other substances of the drug;
- with arterial hypotension, the drug should be used with caution.
It is necessary for the patient to administer the drug only while lying down, because in this case there is a risk of collapse.
Overdose with no-spa
The instruction does not have information about cases of overdose with this medicine.
Drug Interactions with Other Drugs
With simultaneous use with levodopa, no-shpa reduces its antiparkinsonian effect.