Blocktran GT is an antihypertensive agent. The main purpose of its use is the treatment of hypertension.
In the article, we consider the instructions for this tool, analogues and reviews about it.
Hypertension - what is it?
By a term such as “arterial hypertension” is meant a regular increase in blood pressure values of more than 140/90 mm Hg. Art. Sometimes it is a primary or independent pathology that develops in a patient without any specific reason (essential hypertension). And sometimes it becomes a complication or a consequence of other diseases (symptomatic hypertension). This cardiovascular disease is the most common, it makes millions of people around the world go to the doctor every day for help. Few know what it is.
Arterial hypertension is not just an increased value of pressure. The disease hides behind itself a whole list of various kinds of complications from the nervous system, blood vessels, kidneys and heart, which directly affect the health of the patient.
Arterial hypertension is one of the most common causes of death among the able-bodied young population, since the most dangerous consequence of such a disease is a violation of the blood circulation of the brain or stroke.
The composition of the drug
One tablet of the Blocktran medicine includes fifty milligrams of losartan potassium. Additional components: microcrystalline cellulose, lactose monohydrate, low molecular weight povidone, sodium carboxymethyl starch, silicon dioxide, potato starch, magnesium stearate. Shell composition: titanium dioxide, yellow dye, sunset, hypromellose, talc, copovidone, polysorbate 80.
One tablet of Blocktran GT includes hydrochlorothiazide (12.5 mg) and potassium losartan (50 mg). Additional components: microcrystalline cellulose, lactose monohydrate, low molecular weight povidone, sodium carboxymethyl starch, potato starch, silicon dioxide, magnesium stearate.
The composition of the membrane includes hypromellose, polydextrose, red dye carmine, medium chain triglycerides, talc, maltodextrin, titanium dioxide.
What are Blocktran GT tablets for? This will be discussed later.
Drug release form
Biconvex pink round tablets, white on a break. Hue can range from light pink to dark pink. Contour packaging contains ten tablets. In a cardboard bundle from one to six packages.
Indications and contraindications for the use of this drug
As indicated by the instructions for use, "Blocktran GT" is used:
- with arterial hypertension (patients who are prescribed combination treatment);
- to reduce the likelihood of developing heart and vascular diseases and mortality in people with left ventricular hypertrophy and arterial hypertension.
The drug is contraindicated in:
- severe arterial hypotension;
- hyperkalemia
- anuria
- lactose intolerance, glucose-galactose malabsorption syndrome, lactase deficiency;
- dehydration;
- excessive sensitivity to the composition and other derivatives of sulfonylamide;
- refractory hypokalemia;
- minor age;
- diabetes, which is difficult to control;
- pregnancy and lactation;
- Addison's disease;
- serious violations of the liver (over 9 points according to Child-Pugh);
- severe renal impairment (creatinine clearance below 30 ml / min);
- simultaneous use with potassium-sparing diuretics and potassium preparations;
- primary hyperaldosteronism.
Cautious medication
With caution, Blocktran GT is used in the following conditions:
- Violation of the water-electrolyte balance, for example, against the background of vomiting or diarrhea (hyponatremia, hypokalemia, hypomagnesemia, hypochloremic alkalosis).
- In patients with renal failure (creatinine clearance over 30 ml / min), with stenosis of an artery of one kidney (single) and bilateral stenosis of arteries of the kidneys.
- In case of impaired liver activity (below 9 points according to Child-Pugh).
- In the presence of gout and / or hyperuricemia, hypercalcemia, diabetes mellitus, with an allergically aggravated history (developed angioedema in some patients in the past with the use of other drugs, including ACE inhibitors), bronchial asthma, with systemic pathologies of connective tissue (including systemic lupus erythematosus) .
- With hypovolemia (including against the background of large doses of diuretics);
- Patients with an acute attack of angle-closure glaucoma.
- When prescribed along with anti-inflammatory non-steroidal agents, including 2 types of cyclooxygenase inhibitors, with cardiac glycosides.
- Patients with coronary heart disease, the elderly.
Dosage of drug
The tool "Blocktran GT" with arterial hypertension is used internally, regardless of food intake, the frequency of administration - once a day.
The maintenance and initial dosage is equal to one tablet once a day. In some cases, in order to achieve a greater effect, it is increased to two pieces once a day. The maximum dosage per day is two tablets of Blocktran GT.
To adjust the dosage in old age or in patients with renal insufficiency to a moderate degree is not necessary.
To reduce the likelihood of developing heart and vascular diseases and mortality in patients with left ventricular hypertrophy and arterial hypertension, the drug is prescribed according to the scheme below. The standard initial dosage of Blocktran GT is 50 mg once daily. Patients who could not achieve normal pressure while taking such a dose of losartan need to choose a treatment by combining losartan with a small amount of hydrochlorothiazide, if necessary, the dosage of losartan is increased to 100 mg simultaneously with 12.5 mg of hydrochlorothiazide per day, then increase the dose to two tablets (a total of 25 milligrams of hydrochlorothiazide and 100 milligrams of losartan once a day).
Negative reactions
What are the side effects of GT Blocktran? The number of unpleasant symptoms is classified based on the values established by the World Health Organization.
In clinical trials with hydrochlorothiazide / losartan, no side effects specific to this combination agent were observed. Adverse events were limited to those that will be discussed later (when observing hydrochlorothiazide and losartan separately).
The side effects listed below were observed with the use of hydrochlorothiazide and losartan in monotherapy.
Adverse Reactions to Losartan
Lymphatic system and blood: infrequently - hemolytic anemia, ecchymosis, Shenlein-Genoch purple, anemia.
Allergic reactions: rarely - urticaria, angioedema, anaphylactic reactions.
From the side of nutrition and metabolism: infrequently - exacerbation of the character of gout, anorexia.
From the central nervous system: infrequently - memory impairment, anxiety, sleep disturbance, paresthesia, drowsiness, peripheral neuropathy, depression, tremor, confusion, migraine, panic disorders, fainting, anxiety disorders, anxiety; often - insomnia, dizziness, headaches.
On the part of the visual organs: infrequently - a burning sensation and dry eyes, impaired vision, decreased visual acuity, conjunctivitis.
From the auditory organs: infrequently - tinnitus, vertigo.
From the side of the respiratory system: often - cough, nasal congestion, upper respiratory tract infections (pharyngitis, sinusitis, sinusopathy, sore throat, high body temperature); infrequently - discomfort in the pharynx, nosebleed, rhinitis, bronchitis, dyspnea, laryngitis, pharyngitis.
From the gastrointestinal organs: often - dyspeptic symptoms, diarrhea, abdominal pain, nausea; infrequently - toothache, dryness of the oral mucosa, constipation, gastritis, flatulence, vomiting.
Musculoskeletal system: infrequently - pain in the knee, shoulder, arms, arthralgia, fibromyalgia, arthritis, muscle weakness, musculoskeletal pain, joint swelling; often - pain in the legs and back, myalgia, cramps.
From the side of the heart and vascular system: infrequently - dose-dependent orthostatic hypotension, arterial hypotension, brady or tachycardia, palpitations, angina pectoris, arrhythmias, II degree AV block, chest pain, vasculitis, myocardial infarction, cerebrovascular events.
From the genitourinary system: infrequently - impotence, decreased libido, urinary tract infections, frequent urination, nocturia.
From the skin integument: infrequently - erythema, dry skin, blood “rush” to the skin of the face, dermatitis, photosensitivity, alopecia, itching of the skin, excessive sweating, skin rash.
Other manifestations: often - excessive fatigue, asthenia; infrequently - fever, swelling of the face.
Laboratory indicators: infrequently - a higher content of creatinine and urea; often - decrease in hemoglobin and hematocrit, hyperkalemia; very rarely - increased activity of liver transaminases.
On hydrochlorothiazide
Lymphatic system and blood: infrequently - thrombocytopenia, agranulocytosis, purpura, aplastic anemia, leukopenia, hemolytic anemia.
Allergic reactions: less often - anaphylactic reactions.
Nutrition and metabolism: infrequently - hyponatremia, anorexia, hypokalemia, hyperglycemia, hypokalemia, hyperuricemia.
From the nervous system: infrequently - insomnia, dizziness, often - headaches.
From the side of the visual organs: infrequently - xanthopsia, transient visual defects.
From the system of the heart and blood vessels: rarely - necrotizing vasculitis.
Respiratory organs: infrequently - pulmonary edema, pneumonitis, respiratory distress syndrome.
Digestive system: rarely - sialodenitis, pancreatitis, intrahepatic cholestasis (jaundice), irritation of the gastrointestinal tract, epidermal toxic necrolysis, nausea, jaundice, vomiting, constipation, diarrhea.
From the subcutaneous tissue and skin: infrequently - urticaria, photosensitivity.
From the musculoskeletal system: rarely - muscle cramps.
From the urinary system: rarely - impaired renal function, glucosuria, kidney failure, interstitial nephritis.
General disorders: rarely - fever.
If there was a post-marketing use of hydrochlorothiazide / losartan, the following side effects were noted:
- from the digestive system infrequently - hepatitis;
- laboratory analysis indicators: rarely - increased liver transaminase activity, hyperkalemia.
Analogs of GT Blocktran
The drug has the following list of analogues:
- "Brozaar";
- "Renicard";
- Vero-Losartan;
- "Lotor";
- "Vazotens";
- "Lorista";
- Cardomin-Sanovel;
- Losacor
- “Kozaar”;
- "Presartan";
- Karzartan
- Losartan
- "Lakea";
- "Lozap";
- "Lozarel."
Only a doctor should prescribe them. Self-medication is unacceptable.
Drug Reviews
Reviews about GT Blocktran testify to its high ability to reduce pressure, but at the same time, side effects occur when using the drug quite often, mainly joint pain and fatigue.
People say that the drug is effective, there is a positive dynamics of the state. The only problem that interests so many patients is the lack of the drug in pharmacies, it suddenly disappeared for unknown reasons.
Sometimes a high effectiveness of a drug is noted over time, but after a year its effect is weakened.
Cost
The price of GT Blocktran in Russia starts at 160 rubles. It depends on the region and the pharmacy network.