In this article, we will consider the preparations Methododzhekt and Methotrexat. What is the difference between the two? About it further.
"Metoject" is an antitumor drug that has a pronounced immunosuppressive effect, it is a folic acid antagonist. Able to stop cell mitosis. Its main function is also the inhibition of dihydrofolate reductase, which is a key enzyme that restores from dihydrofolium tetrahydrofolate acid. The cost of the drug is from 700 to 1100 rubles.
The most famous analogue of the drug "Method" is the Austrian "Methotrexate Ebeve."
Cost of it is in the range from 400 to 1200 rubles.
Composition of the Methodoject
The main active substance of the drug is disodium methotrexate. Additional components: sodium chloride, sodium hydroxide, distilled water.
Effective against multiplying and rapidly growing cells. This is especially true for epithelial cells and malignant neoplasms.
With constant use, it accumulates in the tissues. It is excreted by the kidneys and bile. If kidney function is impaired, elimination from the body slows down. It can also slow down with poor liver function.
Composition of Methotrexate Ebeve
The composition of the medication contains the same active substance - methotrexate. It has immunosuppressive, antitumor properties.
It has good bioavailability, excreted in the urine and in small quantities with bile. Tends to accumulate in the tissues in the form of metabolites.
So, Metodzhekt and Methotrexate - what is the difference? In composition and action, they are almost identical.
In what cases is a Metodzhekt appointed?
The drug Methodogect is rarely used in oncology. It is prescribed for skin diseases and joint diseases, for example, for:
- Psoriasis, which is difficult to treat.
- Rheumatoid Arthritis.
- Juvenile arthritis.
- Psoriatic arthritis.
The immunosuppressive properties of the drug and anti-inflammatory are triggered. This explains the effectiveness with these ailments.
The use of the drug "Methotrexate"
Basically, Methotrexate is prescribed for the treatment of cancer:
- acute lymphocytic leukemia;
- trophoblastic disease;
- skin cancer;
- cervical and vulvar cancer;
- esophageal cancer;
- squamous cell carcinoma of the head and neck;
- cancer of the renal pelvis and ureter;
- osteogenic and soft-cell sarcoma;
- Ewing sarcomas, lung cancer, breast cancer;
- germ cell tumors of the testis and ovaries;
- liver cancer, kidney cancer;
- retinoblastomas, medulloblastomas;
- penile cancer;
- lymphogranulomatosis.
In addition, it should be noted that the medication is used for severe forms of psoriasis, as well as in the case of severe rheumatoid arthritis (if adequate therapy has been ineffective).
That is the difference. "Metoject" and "Methotrexate" are used for various diseases. So, “Metoject” - for the treatment of psoriasis and arthritis, and “Methotrexate” - for oncology. But they can heal both.
Release Forms
Metoject is a yellow, transparent solution. Sold with syringes that are intended to be inserted under the skin, into a muscle or vein.
"Methotrexate" is in ampoules and tablets.
How are medicines used?
The dosage of the drug is selected by the attending physician individually. Of course, if there are no contraindications. It is applied no more than once a week.
The patient must pass the test before use. In advance, in about a week, they make a test injection with a small amount of medicine, if the body responds normally, then treatment can be carried out.
When side effects occur, the drug is not used. First, the minimum dose of the drug is administered, which is 7.5 mg. Then it is gradually increased with good tolerance and with available indications.
After a couple of months from the first application, you can notice the effect. The course can last quite a long time, up to several years.
Use in pregnant and lactating women
What is the difference here? "Metoject" and "Methotrexate" should not be taken during pregnancy and lactation.
The Metoject is toxic to the fetus and can lead to serious developmental disabilities and even death. In breast milk, it tends to accumulate, which can also negatively affect the health of the baby.
If pregnancy has occurred while taking the drug, then there may be undesirable consequences for the baby. Therefore, careful contraception during therapy is necessary.
We are comparing the Metodzhekt and Methotrexat Ebeve drugs. What is the difference, it became clearer. We understand further.
Contraindications "Methodoct"
The medicine should not be used if there is hypersensitivity to the components. Also, you should not use it with:
- Alcohol abuse.
- Diseases of the liver and kidneys.
- Hematopoiesis.
- Presence of ulcerative lesions in the digestive tract and in the oral cavity.
- Vaccination (due to a decrease in the immune response, vaccination should be carried out only six months after administration is stopped).
- Acute and chronic infections (including recent illnesses).
- Autoimmune diseases.
Careful use should be given if:
- Herpes.
- Pleural and peritoneal effusions.
- Ascites.
- Gout.
- Obstructive diseases of the digestive system.
- Dehydration of the body (disturbed water balance increases the toxicity of funds).
- Asthenia.
- High concentration of bilirubin.
- Vomiting and diarrhea.
- A history of chemical and radiation therapy.
They try not to prescribe a Metoject to older people, since their liver and kidneys may be impaired. In particular, “Metzhekt” and “Methotrexate” are not used for UC (nonspecific ulcerative colitis).
In what cases is it forbidden to use the medication "Methotrexate"?
With severe violations of the liver and / or kidneys, leukopenia, thrombocytopenia, pregnancy and lactation. Immunodeficiency conditions are also a contraindication to the use of Methotrexate.
When rheumatoid arthritis or psoriasis is treated with a medicine, once a month it is necessary to donate blood for biochemistry, also in laboratory conditions it is necessary to check the functions of the kidneys and liver with a frequency of 1-2 times every two months.
If psoriasis is treated, then with the use of the drug, local therapy is continued.
If an overdose occurs, the patient needs to enter a calcium folio within the first four hours.
Interaction with other drugs "Methotrexate"
"Methotrexate" is forbidden to use with the following drugs:
- non-steroidal anti-inflammatory drugs;
- penicillin antibiotics;
- sulfonamides;
- valproic acid;
- kolestiraminom;
- mercaptopurine;
- neomycin;
- paramomycin;
- omeprazole;
- retinoids;
- tetracycline;
- cyclosporine.
These are the contraindications for the Metodzhekt and Methotrexat medicines. What is the difference? Reviews confirm that they are tolerated equally hard.
Interaction of the MethodJect with other means
The simultaneous use of Metodzhekt and other drugs leads either to an increase in toxicity or to a decrease in the therapeutic effect. If you need to combine any means, it is better to inform a specialist.
"Metoject" is taken with caution with:
- Hepatotoxic drugs.
- Drugs that inhibit hematopoiesis.
- Drugs affecting the bone marrow.
- Alcoholic drinks.
- Antibiotics.
- NSAIDs and salicylates.
The prohibited list of medicines is quite large. It must be remembered that the interaction with the Method Method will cause very severe toxic poisoning of the body (death is not excluded). This can sometimes lead to skin cancers.
Green tea and coffee are also banned, as well as drinks with purine alkaloids, theophylline and caffeine. The reason for this is poor compatibility with methotrexate. It can significantly delay their elimination.
It should be noted that during therapy, vitamin complexes and preparations containing folates are indicated, since they reduce toxic properties.
Which drug to choose - “Metoject” and “Methotrexate”? What's better? About it further.
Side effects
Side effects can be different, but most often the organs of the gastrointestinal tract suffer. The frequency and severity of their occurrence depends on the dose and individual characteristics of the body.
Side effects are manifested mainly:
- Stomatitis.
- Nausea.
- Depression
- Anemia
- Dermatitis
- Headache and dizziness.
- Increased sweating and fever.
- Allergy and anaphylactic shock.
- Pericarditis.
- Thromboembolism.
- Interstitial pneumonia.
- Various infectious diseases.
Sometimes:
- Vomiting.
- Baldness.
- Vasculitis
- Pharyngitis.
- Paresthesia of the lower extremities, fingers and toes.
Very rare:
- Cramps and paralysis.
- Visual impairment.
- Pulmonary insufficiency.
- Myalgia.
- Osteoporosis.
Pancreatitis, diabetes, impotence, infertility may develop, and the appearance of neoplasms is not even ruled out.
What is the difference between Metodzhekt and Methotrexate? This question interests many.
It is imperative to undergo regular examinations for those patients who are treated with Metoject. In this way, intoxication can be prevented. The grave consequences of this are terrible, a fatal outcome is possible.
It is forbidden to drive a car during therapy and work with dangerous machinery.
Next, we consider the side effects of drugs such as Metoject and Methotrexate. What is the difference between them?
Side effects of Methotrexate
From the digestive organs, manifestations of ulcerative stomatitis, anorexia, gingivitis, pharyngitis, nausea are possible; in rare cases - diarrhea, melena, enteritis, pancreatitis, liver necrosis, cirrhosis, fatty atrophy, periportal liver fibrosis.
The hematopoietic system can respond with leukopenia, anemia, thrombocytopenia.
Central nervous system - feeling tired, dizziness; in rare cases - headache, aphasia, drowsiness, convulsions.
The reproductive system - a violation of ovogenesis and spermatogenesis, oligospermia, irregular menstruation, decreased libido, impotence.
Urinary system - hematuria, cystitis, severe impaired renal function.
The manifestation of the following allergic reactions is possible: chills, decreased resistance to infection; in rare cases, urticaria, toxic epidermal necrolysis, Stevens-Johnson syndrome.
Dermatological reactions - skin rash, photosensitivity, pigmentation disorders, acne, furunculosis.
If any negative reactions of the body to the drug appear, you should immediately consult a doctor.
Overdose
An overdose is dangerous for the hematopoietic system. In these cases, hydration is indicated. This can accelerate the excretion of the active substance. Folic acid is also prescribed.
Condition and shelf life
We are considering Metodzhekt and Methotrexate. There is also a difference in shelf life.
In a dry, dark place at a temperature not exceeding 25 degrees, these medicines are stored. Be sure to clean away from children. Sunlight and dampness are contraindicated. They can not be frozen.
Metodzhekt is suitable for 2 years from the date of production, Methotrexat - 3 years.
This distinguishes between Metodzhekt and Methotrexate. What is the difference yet?
In comparison with the "Metoject", we can distinguish some of the distinctive qualities of "Methotrexate". Side effects are possible, but, according to patients, are less common. Also, Methotrexate is also available in tablets, for many patients this form is more convenient.
So, we have described in detail the use of the Metodzhekt and Methotrexat preparations. What is the difference now is clear.