The antitumor agent Afinitor, the instructions for which will be brought to your attention later in the article, is produced by the well-known firm Novartis (Switzerland).
Its main active ingredient is everolimus, which is a selective inhibitor of serine-threonine kinase. The activity of the latter increases with the development of many human oncological pathologies. Everolimus binds to intracellular proteins, thereby preventing their synthesis and signaling, in addition, it reduces the growth of the endothelium of the vessels that feed the tumor. Thanks to this, the development of the latter slows down, or even stops.
Studies have shown that due to the use of a drug containing everolimus, 67% of patients with renal cell carcinoma reduced the risk of disease progression and increased life expectancy.
Where can I get the generic drug "Afinitor"
It's no secret that the purchase of necessary medicines these days is a big problem because of their high cost. So, in Moscow, the price of the drug “Afinitor” is 173,000 rubles. for 30 tablets. But during the treatment, the patient will need more than one package! In this case, generics will come to the rescue - licensed drugs that have the same active substance, but are at the same time several times cheaper.
The low cost of these medicines is explained by the fact that the company that bought the license for their production does not spend money on development, testing and advertising. And this means that such a tool can pay off at a much lower retail price.
Online You can order and purchase, issued by the famous Indian company Biocon Ltd. Everolimus tablets 5 mg and 10 mg, having a completely similar composition and, accordingly, action. And the price proposed for the generic “Afinitor” tablets will be almost three times more affordable compared to the original (brand) drug.
Indications for use
We warn you that the instructions for use proposed in the article on “Afinitor” tablets apply equally to their Indian counterpart. The tool should be prescribed only by a specialist. It is shown to certain groups of patients:
- having neuroendocrine tumors of the pancreas, lung, and gastrointestinal tract;
- suffering from renal cell carcinoma (in the absence of the expected effect of the use of antiangiogenic drugs);
- in case of hormone-dependent breast cancer in postmenopausal patients (in combination with an aramatase inhibitor);
- with subependymal astrocytoma in children after 3 years;
- with kidney angiomyolipoma and tuberous sclerosis.
Tablets are taken once a day (preferably in the morning). They should be swallowed whole, without chewing, and washed down with plenty of water. Treatment usually lasts until there is a clinical effect. The average dose of the Afinator drug is 10 mg, but in the presence of pronounced side effects it is reduced to 5 mg.
Side effects
Taking the Afinitor tablets, the instructions for which are provided in our article, often cause unwanted side effects:
- headache;
- sleep disturbances;
- anemia
- swelling of the eyelids and conjunctivitis;
- increase in blood pressure;
- shortness of breath, cough, nosebleeds;
- diarrhea, lack of appetite, dry mouth and abdominal pain;
- the appearance of rash and itching;
- weight loss and dehydration;
- development of edema;
- increased blood cholesterol.
In view of the listed problems that may occur during treatment with the drug, its appointment and monitoring of the patient's condition should be carried out only by a specialist.
Contraindications
Tablets "Afinitor" are not shown to everyone. So, their purpose is not allowed:
- during pregnancy and lactation;
- with increased sensitivity to the components of the drug;
- under the age of 18;
- in the case of the use of CYP3A4 inducers.
In addition, you should be careful with the appointment of the agent "Afinitor" before surgery, since it can slow the healing of wounds. During treatment and within 2 months after it, patients with intimacy should be protected from pregnancy.