What is prescribed and how to use the Butadion medication (tablets) from? Instructions for use, indications, properties and features of this drug will be presented in this article.
Also in it you will find information about how much the mentioned remedy costs, what ingredients are included in its composition (active and inactive) and whether it has side effects.
Composition and packaging of the drug
What components are contained in Butadion? Tablets include an active substance such as phenylbutazone. Also, the composition of the drug includes: potato starch, primellose, magnesium stearate, sodium bicarbonate, talc and silicon dioxide.
The drug "Butadion" (tablets) goes on sale in blisters that are enclosed in cardboard packaging.
Pharmacodynamic characteristics of the drug
Do you know what a drug like Butadion is? Reviews of experts report that this is a non-steroidal anti-inflammatory drug that has an antipyretic and analgesic effect.
The effectiveness of this tool is associated with its ability to suppress the activity of cyclooxygenase. As a result of this effect, the synthesis of prostaglandins is slowed down.
The medication in question enhances the reverse absorption of salts and water in the tubules of the kidneys. It also eliminates pain syndromes and reduces swelling, which often accompanies inflammatory processes.
How is the therapeutic effect of Butadion? Tablets reduce joint pain (during movement and at rest), and also restore their mobility or increase range of motion.
The anti-inflammatory effect of this agent is in many ways superior to that of the similar drug Amidopyrine.
With gout, this medication doubles the release of urate with urine, and also reduces their amount in the blood.
It should also be noted that the drug “Butadion” (tablets), the instructions for use of which are enclosed in a package with blisters, reduces pain and signs of inflammation in thrombophlebitis (postoperative and hemorrhoidal veins).
Kinetic features of the drug
Where is the drug Butadion (tablets) absorbed? The instruction reports that the high absorption of this drug comes from the digestive tract. Its bioavailability is about 87-90%, and the maximum plasma concentration is observed 60-150 minutes after administration.
From the blood, the drug gradually passes into tissues and organs, and also penetrates into the joint cavities and through the blood-brain barrier.
The metabolism of this drug is carried out in the liver. Its half-life is 19-25 hours. The medication is excreted through the kidneys and through the digestive tract.
Indications for taking pills
In what cases is the drug "Butadion" prescribed? Tablets are effective in the treatment of:
- Ankylosing spondylitis;
- osteoarthritis;
- psoriatic arthritis;
- rheumatoid and lupus arthritis;
- bursitis and tenosynovitis;
- gouty arthritis;
- algodismenorea;
- postoperative pain syndrome;
- toothache and headache.
Also, this medication is used to stop unpleasant sensations with neuralgia, burns and radiculitis.
Contraindications to taking the medication
How much is the drug we are considering? What is its price? "Butadion" can be purchased at any pharmacy at a very reasonable cost. We will present it at the very end of the article.
Are there any contraindications for this medicine? According to the instructions, this medication should not be used for:
- history of bleeding from the digestive tract;
- intolerance to acetylsalicylic acid;
- heart rhythm disturbance;
- hypersensitivity to phenylbutazone;
- bone marrow depression;
- exacerbation of ulcerative colitis and gastrointestinal ulcer;
- decompensated heart failure;
- hepatic and renal failure;
- hyperkalemia
- under the age of 12 years;
- pregnancy, especially in the first and third trimesters;
- at the same time taking other drugs that contain phenylbutazone.
Instructions for use of the drug "Butadion"
According to the instructions, the drug "Butadion" is taken orally after meals, 150 mg four times a day. The largest single dose of this medicine is 200 mg, and the daily dose is 600.
The duration of therapy with this agent depends on the severity of the disease and the condition of the patient. A dose of 400-600 mg per day can reduce the amount of urine in diabetes insipidus.
Teenagers from 12 years of age, butadion tablets are prescribed 75 mg three times a day. In order to prevent the irritating effect of this drug on the gastric mucosa, it is recommended to drink it with warm milk.
In the presence of joint diseases, the effect of the medication is enhanced by the simultaneous administration of Prednisoloneum (drip, intravenous).
It should also be noted that to increase the therapeutic result, Butadion tablets are combined with Butadion ointment.
Side effects after taking the pills
Taking Butadion tablets may cause the following systemic reactions:
- nausea, abdominal pain, dyspepsia;
- vomiting, aphthous stomatitis, heartburn;
- ulceration of the gastrointestinal tract mucosa, diarrhea, tinnitus;
- gastrointestinal bleeding;
- gingival and hemorrhoidal bleeding;
- increase in blood pressure;
- violation of the liver;
- headaches, anemia, depression, leukopenia, dizziness;
- drowsiness, agranulocytosis, agitation, thrombocytopenia.
Blood side effects require discontinuation of the drug and contact a specialist.
The delay in water and sodium in the body associated with the use of "Butadione" significantly worsens the condition of patients with hypertension and heart failure. This point also requires adjustment in treatment.
Similar medicines and price
"Butadion" in tablets (20 pieces) can be purchased for 40-70 rubles.
As for the analogues, the following agents are used as them: Butadion-OBL, Arthrizin, Phenylbutazone, Butalidon.
Patient reviews about the drug
Now you know what the price of Butadion is. Tablets are inexpensive, but as for the reviews, they will be presented below.
Analyzing the responses of patients about this drug, we can safely conclude that it is effective in any joint and muscle pain. But, in addition to positive reviews, patients often make negative reports about him. According to them, Butadion tablets quite often cause complications from the digestive tract and blood. In this regard, most doctors recommend refusing to take this medicine and replace it with a safer drug.