In 1954, Benfotiamine was synthesized by Sankyo Japanese scientists. The created compound is similar to thiamine in its activity. Thus, benfotiamine is a fat-soluble synthetic analogue of vitamin B1.
Pyridoxine is a water-soluble vitamin B6 that is ingested with various foods. Thus, the substances benfotiamine and pyridoxine are independent therapeutic agents and in the complex are part of other drugs.
Pharmacological action of B1 and B6
Benfotiamine is characterized by enhanced penetration into the peripheral nerves, the highest concentration of the substance in plasma, liver, cerebrospinal fluid, red blood cells and the ability to persist for a long time in the human body. It has a higher bioavailability compared to water-soluble B1.
Metabolic effect on the body:
- normalizing the metabolism of carbohydrates, compensates for the deficiency of thiamine;
- actively participates in metabolic processes;
- regulates the activity of the nervous system, improves the conduct of an impulse of nerve endings;
- normalizes carbohydrate-energy metabolism in tissues;
- protects blood vessels, nerve fibers from damage by glycotoxins.
Pyridoxine is a water-soluble form of vitamin B6 necessary for the full functioning of the central nervous system. It stimulates metabolic processes, participates as a coenzyme in the metabolism of proteins and amino acids, and has an effect on lipid and fat metabolism in the body.
The therapeutic use of active neurotropic substances is justified by the insufficient intake of B vitamins in the body. Benfotiamine and peridoxin in the complex have a pronounced effectiveness of the effect and have the most positive therapeutic effect. The use of B1, B6 in diseases of various origins is aimed at filling their deficiency and stimulating natural recovery mechanisms.
For compounds of benfotiamine and pyridoxine, the trade name depends on the patent of a pharmaceutical company for the production of medicines in which they are present as primary or secondary. In our country, the most common combination preparations containing these substances are Polynervin, Benevron, Benfogamma, and Milgama Compositum.
Combined multivitamin preparation
Benfotiamine and peridoxin favorably affect the effectiveness of treatment in their complex combination. Such a drug is Milgamma Composite. The therapeutic effect is aimed at enhancing metabolic processes in tissues and organs, regulating the energy resources of cells, restoring the conductivity of nerve impulses.
It is widely used in inflammatory processes, degenerative diseases of the musculoskeletal system, pathologies of the central nervous system, for relief of pain. Provides a moderate analgesic effect.
The drug is available in two dosage forms: injection (solution) and tablet (dragee). The composition of the solution for injection further includes cyancobalamin - vitamin B12. The price of Milgamma Compositum varies depending on the dosage form. So, 10 ampoules of 2 milliliters each cost about 500 rubles, and a pack of 100 mg tablets of 60 pieces - 1180 rubles.
Indications for use
Benfotiamine (B1) and peridoxin (B6) are used in case of deficiency of one of the vitamins and comprehensively as a means for symptomatic treatment of a number of diseases:
- CNS pathologies of various origins: myalgia, neuritis, neuralgia, radicular syndrome, paresis, paralysis, diabetic or alcoholic polyneuropathy;
- atherosclerosis;
- anemia;
- Alzheimer's disease;
- acute, chronic intoxication;
- diseases associated with circulatory disorders;
- inflammatory and degenerative diseases of the musculoskeletal system;
- viral hepatitis;
- cirrhosis of the liver;
- seasickness;
- Meniere's disease;
- shingles;
- neurodermatitis;
- dermatitis
- herpes and others.
In addition, in combination with other drugs can be used as a means with anesthetic effect.