Various diseases of the joints and spine can cause severe pain and permanently reduce a person’s performance. Therefore, it is very important to use such drugs that would quickly alleviate the patient's condition. Now there are many similar drugs. External remedies are popular in such cases. They almost do not cause systemic side effects, like pills, but quickly relieve pain in joints and muscles. Particularly effective are preparations based on non-steroidal anti-inflammatory substances, for example, Nise gel. This tool is used very often for various diseases of the joints and spine.
General characteristics of the drug
Nise Gel is an anti-inflammatory and analgesic drug for external use. Its action is based on a non-steroidal anti-inflammatory drug of the latest generation, belonging to the class of sulfonanilides. This is nimesulide, which has a local analgesic, anti-inflammatory and antipyretic effect.
The drug is a transparent gel without impurities. It may have a white or slightly yellowish color. The gel is produced in aluminum tubes of 20 or 50 ml. The main active ingredients of the drug are nimesulide, methyl salicylate, methanol and capsaicin.
You need to store the gel in a dark, dry place, away from sunlight and heating appliances. But placing the drug in the refrigerator is also not recommended. Because of this, its effectiveness is reduced. When foreign impurities appear in the gel, a change in color or texture cannot be used.
Features of active substances
The effectiveness of the Nise gel is explained by its composition. The main active ingredient of the drug is nimesulide. This drug from the NSAID group, refers to sulfonanilides. Nimesulide effectively blocks the synthesis of prostaglandins. And without these substances it is impossible to develop an inflammatory process, edema or pain. Nimesulide acts only on painful areas.
An additional effect on the tissue is provided by another component of the Nise gel - methanol. This substance has antiseptic, analgesic and sedative properties. Irritating the nerve endings of skin receptors, methanol stimulates the production of enzymes that reduce pain. In addition, it regulates the permeability of blood vessels, narrows them. This provides an antipruritic and distracting effect.
Another active ingredient in the Nise gel is methyl salicylate. It quickly penetrates into the deep subcutaneous layers, turning into salicylic acid. This substance is able to suppress the synthesis of enzymes responsible for the inflammatory process, the appearance of pain and swelling. In addition, salicylic acid normalizes microcirculation and reduces capillary permeability.
In addition, capsaicin has an auxiliary effect. It is contained in the gel very little, but it has a locally distracting effect, contributing to a rush of blood to the skin and improving metabolic processes.
What effect does the gel have?
The drug is intended for topical use. After application to the skin, the active substances are absorbed into the tissues, providing an analgesic and anti-inflammatory effect. You can find out what other properties the drug has in the instructions for the Nise gel. Reviews of patients note that its effect occurs quickly. Due to the properties of the components of the drug, the following effects are observed:
- Pain is reduced.
- The inflammation decreases.
- Itching passes.
- The capillaries are narrowed, which provides a cooling and soothing effect on the tissue.
- Trophic tissue improves.
- Microcirculation and metabolic processes in tissues are activated.
- Swelling is reduced.
- The motor functions in the joints are restored.
Indications for use of the drug
The gel is intended for topical use in various diseases of the spine, joints, muscles and ligaments. It has only analgesic and anti-inflammatory effects, so it should be used as part of complex therapy. He can not cure serious diseases, as it only relieves the symptoms. Most often it is recommended to use the Nise gel in such cases:
- Inflammatory diseases of the periarticular tissues - bursitis, synovitis, tendonitis, tenosynovitis.
- Different types of arthritis joints.
- Sciatica, sciatica or lumbalgia.
- Osteoarthritis and osteoarthrosis.
- Neuritis and neuralgia;
- Soreness in the muscles.
- Ankylosing spondylitis.
- Rheumatism.
- Gout.
- For pain in the back, joints or muscles of unknown etiology.
- After bruising or injury without damaging the skin.
Contraindications
The drug relieves pain very effectively, but not everyone can use it. Instructions for use of the gel "Nise" notes that there are a number of cases in which such treatment is contraindicated. You can not use the drug in such cases:
- In the presence of individual intolerance to the components of the drug.
- During pregnancy and breastfeeding.
- Children under 7 years old.
- In the presence of ulcerative lesions of the gastrointestinal tract or bleeding.
- In case of skin damage, dermatosis, eczema, inflammatory or infectious diseases.
- With renal failure.
- Impaired liver function.
- With pathologies of the blood forming organs.
- With bronchial asthma, the phenomenon of bronchospasm after applying NSAIDs.
In addition, only by the doctor’s prescription and with great care, Nise gel can be used for children under 14 years of age, elderly people, as well as patients with cardiovascular pathologies, high blood pressure, and diabetes.
Feasible side effects
The instruction for Nise gel warns of a possible allergic reaction to the drug. In this case, it can not be used. But sometimes there are also negative effects on the skin after applying the gel. They are usually mild and after a while pass. This is redness, burning sensation, or itching. A rash or peeling may appear. This is due to the characteristics of the active substances of the drug, which have locally irritating properties.
Sometimes, when exceeding the recommended dosage or with prolonged use of the drug, systemic side effects may develop due to the fact that the active components are absorbed into the blood. Instructions for use of the Nise gel necessarily warns of the possibility of their occurrence. Reviews of doctors and patients note that they appear infrequently, but you should not apply the drug to large areas of the skin. Indeed, at the same time, the appearance of such reactions is possible:
- Nausea, vomiting.
- Digestion, abdominal pain.
- Burning sensation in the throat or chest.
- Headaches, dizziness.
- Violation of the liver.
- Swelling.
- Severe allergic reactions, even anaphylactic shock.
- Violation of the composition of the blood.
Benefits of using
Despite the large number of contraindications and side effects, Nise is more effective than other similar drugs. The active substances are easily absorbed into the tissue, reaching the site of inflammation. This provides a quick onset of analgesic effect. In addition, the drug is considered safer when compared with analogues. Active substances are released gradually, without creating a high concentration in the blood. Therefore, the drug is usually well tolerated by patients who have no contraindications to it. Only in rare cases, side effects occur that quickly disappear after discontinuation of the drug. The active substances of the drug do not accumulate in the tissues or blood, and after a day are completely excreted through the liver.
Application rules
You can use the Nise gel only as directed by your doctor, strictly following all its recommendations. If used incorrectly, the risk of side effects increases and the effectiveness of treatment decreases. There are several rules that must be followed when using the drug:
- You can apply the gel only on intact skin. In the presence of ulcers, scratches or open wounds, the drug can not be used.
- Before applying, wash your skin with soap and dry well. This will help improve the absorption of the drug.
- The gel must be applied with a thin layer, you can not rub it. It is advisable that only a patch of skin over a painful spot is exposed to treatment.
- Dressings or compresses should not be applied on top of the applied preparation.
- Avoid contact of the gel with mucous membranes, especially in the eyes. In case of accidental contact, rinse eyes with plenty of water and consult a doctor.
- After application, wash your hands well with soap. You can also use gloves or special spatulas for application.
Dosage
To ensure the effectiveness of the drug and the absence of side effects, it is necessary to strictly follow the instructions. Gel “Nise” is recommended to be applied on clean skin no more than 3 g at a time. This amount corresponds to 3 cm of extruded strip of gel. Then the drug is evenly distributed over the affected area, without rubbing into the skin. A strip of not more than 2 cm is applied to children.
You can repeat the treatment procedure up to 3-4 times a day, but not more often than every 8 hours. It depends on the severity of the patient's condition, sometimes it is enough to use it only once. Children should not use the drug more often 1-2 times a day. Treatment lasts no longer than 10 days. In mild cases, the pain disappears in 2-3 days, if after a week there is no relief, it is necessary to consult a doctor to replace the drug.
Application features
When using the drug, be sure to follow all the doctor's recommendations. In no case should you use Nise during pregnancy and lactation. In case of joint pain, another, safer medicine must be used. You should also consider the possibility of systemic side effects. The risk of this increases with the patient taking certain drugs. Nise is incompatible with other non-steroidal anti-inflammatory drugs, drugs to lower blood pressure and normalize blood sugar. It cannot be used during treatment with diuretics, Phenytoinum, Digoxinum, Cyclosporinum, and also the preparations containing lithium. To avoid the negative phenomena associated with the drug drug interactions, before using Nise, you must definitely study the instructions.
Analogs of gel "Nise"
This drug is considered one of the most effective local painkillers. But not everyone can take advantage of it.
For some patients, its use is contraindicated. In this case, you can use analogues of the gel "Nise". The ointments "Sulaydin", "Nimulide" and "Nimesulide" have exactly the same composition. Drugs based on other non-steroidal anti-inflammatory substances have a similar effect: Dolgit, Voltaren, Diclofenac, Fastum, Ortoflex.
Reviews on the use of Nise Gel
Joint or muscle pain is familiar to almost every person. Even if there are no serious diseases, they can occur due to overvoltage, slight injury, constant increased loads. Therefore, many have to use local anti-inflammatory drugs. Sometimes reviews help you choose the best tool. Gel "Nyz" earned the most positive feedback from patients. I like this drug for the quick onset of effect, rare side effects, as well as a low price. You can buy packaging at a price of 190 to 300 rubles, depending on the dosage. You can buy this drug in any pharmacy without a doctor’s prescription. Only 2-3 applications of the gel help to get rid of pain and discomfort, restore joint mobility and performance. This fact is noted in almost every review about the drug.