Cream “Clindacin B Prolong” is a combined preparation of local type of effect, has antibacterial and antifungal effects. It is used in gynecology.
In terms of the form of the drug, “Clindacin B Prolong” is a vaginal cream that is either white with a shade of gray or white. The smell of the drug is specific. Aluminum tubes contain six or twenty grams, a cardboard bundle includes one tube, which has one or three applicators in the kit. Active substances are clindamycin and butoconazole nitrate. This is confirmed by the instructions for the cream "Clindacin B Prolong."
Pharmacological Impact
Clindamycin is a bacteriostatic antibiotic belonging to the group of linkosamides, has a fairly wide functioning. Combining with the 50S subunit of the ribosomal membrane, it inhibits protein synthesis in the composition of the microbial cell. Some gram-positive cocci may have a bactericidal effect. It is also active against Staphylococcus aureus (including epidermal staphylococcus), streptococci (except for enterococcus fecalis), pneumococcus, Corynebacterium diphtheriae, mycoplasma, microaerophilic and anaerobic gram-positive cocci, Clostridioeridium perfume, Clostridioeridium perfume and eubacterium. Most of the strains of Clostridium perfringens are sensitive to clindamycin, although other types of clostridia are resistant to its effects, and therefore, antibiotics should be determined for infections caused by them. This is indicated in the instructions for use with Clindacin B Prolong cream.
Butoconazole is an imidazole derivative, has a fungicidal type activity against fungi belonging to the genera Candida, Microsporum, Trichophyton, Epidermophyton and a number of gram-positive bacteria. It is especially effective for candidiasis. By blocking the process of the appearance of ergosterol from lanosterol in the cell membrane, it increases the permeability of the latter, resulting in a lysis of the fungal cell.
A creamy hydrophilic base allows the preparation to have a gel consistency at a temperature of thirty-five to forty degrees Celsius. If you apply the cream intravaginally, it does not melt, so that the active substances remain on the vaginal mucosa for one to three days. Between linko- and clindamycin there is cross-type resistance.
Indications and contraindications
The indications of the cream “Clindacin B Prolong” are fungal, bacterial, as well as mixed vaginoses, caused by microorganisms that are sensitive to this drug.
Contraindications are:
- ulcerative and pseudomembranous colitis (including history);
- Crohn's disease;
- age up to eighteen years;
- high sensitivity to any component of the drug.
It should be used with caution in the presence of allergic diseases, as well as with the joint use of muscle relaxants.
Dosage
Cream “Clindacin B Prolong” must be administered intravaginally through the applicator. It must be used once, it is advisable to do this before going to bed. The recommended dose is one full applicator, that is, five grams of cream, one hundred milligrams per share of both active substances. The course of treatment is three days, use is made daily.
Some tips for using the product
In the package there are applicators for single use, which contribute to the correct introduction of the drug into the vagina.
You must perform the following steps:
- First you need to remove the cap from the tube and install the applicator on its neck.
- While pressing on the opposite end of the tube, gently squeeze the cream into the applicator. Its piston moves independently as the required quantity is filled. The applicator is filled when the piston reaches the stop.
- The applicator must be taken horizontally and, lying on its back, enter it into the vagina as far as possible, but in such a way that there are no unpleasant sensations.
- Slowly push the piston all the way.
- Carefully pull out the applicator and discard, as it is disposable.
This is described in the instructions for use with Clindacin B Prolong Cream.
Side effects
Most often, this drug is well tolerated, but it can still cause irritation at the injection site, itching, burning, pain and swelling of the vaginal mucosa, cramping or pain in the lower abdomen. Allergic reactions are also possible.
Side effects may include manifestations:
- cervicitis;
- vaginitis;
- vulvovaginal irritation;
- reversible leukopenia;
- neutropenia;
- eosinophilia;
- agranulocytosis;
- thrombocytopenia;
- maculopapular rash;
- urticaria;
- itching
- in rare cases, pseudomembranous enterocolitis.
No cases of drug overdose with its correct use have been identified.
Interaction with other medicines
Antagonistic relationships between clinda- and erythromycin are noted. In addition, Clindacin B Prolong cream is incompatible with those solutions that contain vitamin B, ampicillin, aminoglycosides, magnesium sulfate and calcium gluconate.
special instructions
In the case of maintaining the clinical characteristics of the infection after the treatment has been completed, a microbiological examination must be repeated to identify the pathogen and confirm the diagnosis.
If irritation appears on the vaginal mucosa or pain occurs, treatment should be discontinued.
Do not use vaginal cream “Clindacin B Prolong” in conjunction with other intravaginal preparations.
You can use the drug during pregnancy and lactation when the possible benefit for a woman is higher than the risk for the fetus or baby.
Children and adolescents before adulthood should not be used.
The drug does not affect the concentration of attention and speed of reactions.
The drug is released only with a prescription.
It must be stored at a temperature of 15 to 25 degrees in a place where children can not penetrate. The shelf life of the drug is two years.
Cream “Clindacin B Prolong”: reviews of women
Reviews on the drug are positive. This drug is considered effective and is recommended for use. The presence of the applicator allows you to enter it with convenience and as it is necessary. Since the texture of the cream is liquidish, it is introduced only lying down, and it is undesirable to get up after that. Patients note a decrease in itching after a single use, and after two tubes its complete disappearance. But still, it is recommended that a full course of treatment be given. Among the side effects, slight irritation is noted in some patients, however, it soon disappears and does not bring serious inconvenience.
The drug is advised to be used by everyone who suffers from vaginosis, but you must first consult your doctor. As a small minus, patients indicate a high price. However, this drug is worth the money.
The price of cream “Clindacin B Prolong”
Cream costs about 200-300 rubles. The price depends on the region and the pharmacy chain.
Analogs
Structural analogues with the same active substance are:
- "Zerkalin."
- Klindafer.
- Dalacin.
- Klines.
- Klimitsin.
- "Klindovit."
- "Dalacin Ts phosphate".