The medicine "Etaperazin", the price of which is 250 rubles, is a neuroleptic (antipsychotic drug), a piperazine derivative of phenothiazine.
Presumably, the effect of the drug is due to the blocking of dopamine postsynaptic receptors in the mesolimbic brain structures. The medication has a strong antiemetic effect - the central mechanism is manifested in the inhibition or blockade of D2 dopamine receptors by the trigger homoreceptor cerebellar zone, and the peripheral one - in the blockade in the gastrointestinal tract of the
vagus nerve. The drug also has an alpha-adrenergic blocking effect. Sedative and anticholinergic effects can be of weak or moderate intensity, hypotensive activity is weak. The medicine "Etaperazin" (reviews of experts confirm this) also has a relaxing effect on the muscles. The antiemetic effect can be enhanced by sedatives and anticholinergics. Withdrawal of the drug occurs mainly with urine.
Appointment
The tool "Etaperazin" instructions for use recommends for the treatment of mental disorders, accompanied by agitation and hyperactivity. Indications include schizophrenia, neurosis, complicated by tension, fear. The drug is indicated for skin itching, to eliminate vomiting or nausea of a different nature.
Medication "Etaperazin".
Instructions for use
The recommended dose for patients from 12 years old is 4-80 mg. Due to the chronic course of pathologies, the amount of medication is allowed (on the recommendation of a specialist) to increase to 150-400 mg. The duration of administration and its frequency per day is determined solely by the doctor.
Side effects
The tool "Etaperazin" (instructions for use warns about this) can provoke extrapyramidal reactions of the parkinsonian and dystonic type, melanosis, cholestatic jaundice, blurred vision, photosensitivity. Undesirable effects include akathisia, a skin rash accompanied by dermatitis, drowsiness, difficulty urinating. Based on the treatment, a violation of accommodation, dry mouth is likely. Heat stroke and agranulocytosis are rarely observed.
Contraindications
Means "Etaperazin" instructions for use does not allow for appointment with hepatitis, cirrhosis, hematopoiesis, nephritis, hemolytic jaundice, during lactation. Contraindications include pathologies of the spinal cord and brain of a systemic type in a progressive course, pregnancy, bronchiectasis in the late stage, hypersensitivity. The drug is not recommended for thromboembolic diseases, heart disease decompensated type. Caution when prescribing the drug "Etaperazin" (instructions for use contains such data) is shown for Parkinson's disease, alcohol intoxication, and liver dysfunction. Dose adjustment may be required with a predisposition to the occurrence of glaucoma, epileptic seizures, chronic respiratory system pathologies. The medication mentioned is used with caution in the treatment of weak, malnourished patients, elderly patients and children.