Instructions for use "Contricale" indicates that this drug is used not only for bleeding. Used for both humans and animals. Basic physical and chemical qualities: the active element is white or almost white in the form of a lyophilisate in bottles. In ampoules: colorless, transparent mixture.
Pharmacology
Polyvalent protease inhibitor, exhibits antiproteolytic, antifibrinolytic and hemostatic effects.
It has a wide range of inhibitory effects and for this reason it can be used not only as an antifibrinolytic, but also as a preventive and therapeutic drug for pathologies of other enzyme systems. Activity is expressed in inactivating units (KIE), as well as in antitrypsin units (ATPE).
The presence of antiprotease activity establishes the high effectiveness of aprotinin in pancreatic lesions and other conditions, accompanied by a significant occurrence of kallikrein and other proteases in plasma and tissues. It reduces the fibrinolytic dynamics of the blood, delays fibrinolysis and exhibits a hemostatic effect in coagulopathies. The blockade of the kallikrein-kinin system makes it possible to use it to prevent and cure various forms of shock.
What is Contrical used for?
Instructions for use "Contricale" (tablets do not exist, there are only ampoules), the main indications indicate the following:
- acute inflammation;
- prevention of postoperative pancreatitis and fat embolism;
- bleeding and hemorrhage due to hyperfibrinolysis (post-traumatic, postoperative);
- severe hemorrhagic complication during thrombolytic therapy ;
- shock conditions.
Contraindications
According to the instructions, the drug cannot be used for hypersensitivity to the initiative substance, while the baby is waiting (namely, before the start of the fourth month). Mindfulness should be observed when using "Contrikal" by patients with a polyvalent allergy. Already in the second and third trimester, the medication can be used only for special indications. Not compatible with antibiotics and solutions, including lipids, amino acids, polysaccharide. You can buy it only with a prescription. In the event that there is a need to use "Contrical" analogues, the instructions for use should be carefully studied, since the secondary effects and contraindications of the drugs may vary.
Warnings
Instructions for use "Contricale" in ampoules has some warnings. Before starting therapy, it is recommended that a dermatological check be carried out in order to establish personal susceptibility to Contrikal.
If the introduction shows signs of allergy or intolerance, you should immediately interrupt the procedure. When Contrikal is added to heparinized blood, the coagulation time of whole blood increases. Contrical does not need to be combined with other pharmaceutical drugs, especially Ξ²-lactam antibiotics due to their incompatibility.
It can not be used in conjunction with solutions including polysaccharide, solutions for parenteral feeding, including amino acids and lipids. It is not recommended to use alcohol during the use of "Contrical".
Method of use and dosage
In the case of a critical condition with pancreatitis, you need to enter this medication as soon as possible. It is administered intravenously, in a jet, without rushing, up to 20-30 thousand units (2-3 ampoules) per day. In the future, a similar dose is administered intravenously. Such treatment should be continued until the patient's condition improves.
The instructions for the use of "Contrical" in pancreatitis indicate that for the prevention of exacerbations of the disease during surgical operations, an initial dose of 20 thousand units is administered, then 10 thousand units up to 4 times a day, but every 6 hours.
In case of a shock condition, a massive portion of 200 thousand units is introduced simultaneously (intravenously, by stream, without rushing), then 140 thousand every 4 minutes.
To prevent fat embolism, 200 thousand are administered every day, in the 1st period - in a stream, in the following days - drip.
Instructions for the use of "Contrikal" (dropper) are as follows: in case of bleeding during childbirth, it is administered from 700 thousand up to 1 million units. Then they inject again at 700 thousand (up to the stage of stopping bleeding).
The daily portion for the child is calculated based on the body weight of the young patient - 14 thousand per 1 kg of weight.
Dicinon
"Dicinon" belongs to drugs that affect the cardiovascular system. Antihemorrhagic substance. It inhibits the decomposition of mucopolysaccharides of the vascular wall (antihyaluronidase dynamics), due to which it restores its permeability in painful processes. It also acts hemostatically by increasing the rate of creation of the primary thrombus (the effect is due to the stimulation of the formation of tissue thromboplastin). It does not affect prothrombin time and does not have hypercoagulation qualities. The onset of action is 5-15 minutes after injection and 1-2 minutes after oral use. Duration of action is 4-6 hours. After a course of treatment with a substance, the result remains for 5-8 days.
Tachocomb
"Tachocomb" is considered an absorbent hemostatic drug for topical use. Tachocomb consists of a collagen plate covered with elements that help blood coagulate. Upon contact with a bleeding wound or other body fluids, coagulation factors in the covering membrane are emptied, thrombin transforms fibrinogen into fibrin. The Tachocomb plate sticks to the wound surface due to polymerization; for the duration of this process (approximately 3-5 minutes), the plate should be pressed to the wound surface. In the body, the components of the Tachocomb plate undergo enzymatic cleavage for 3-6 weeks. A special manufacturing and sterilization procedure provides the greatest security in terms of getting microbes and microorganisms in the contents of the plate. Use this tool only on the recommendation of a doctor.
"Hamamelis"
The medicine "Witch hazel" is used as homeopathy. The tool helps to strengthen the venous walls, improve microcirculation, the destruction of venous stasis. The drug is effective for pathologies of blood circulation in the lower extremities against the background of varicose veins, with manifestations of hemorrhoids. The use of "Hamamelis" may be accompanied by a short exacerbation of existing symptoms. In some cases, an allergic reaction to the components of the product is likely. When using homeopathic remedies, hypersensitivity manifestations are extremely rare, but it is necessary to focus on uncharacteristic dermatological rashes during the treatment with a pharmaceutical agent. The decision to cancel the product should be made only by the doctor after evaluating the symptoms.
Reviews
Often, reviews and instructions for the use of "Contrikal" can be found on veterinary forums, since it is also used to cure animals. Reviews about this drug when used by people are most often excellent. However, on the forums of doctors you can see a more controversial attitude to the product.
Often, experts doubt that it is necessary to use "Contrical" for bleeding, as it delays other numerous mechanisms of protein breakdown. And this can have a negative effect on the patient's condition. In general, only a competent doctor can use the medication. Such a professional should understand very well how Contrikal affects a variety of physiological processes, and compare the threat and benefits of therapy. Therefore, no self-medication!