Do you know what Bifosin is? Instructions for use, price, reviews and indications for taking the mentioned drug will be described later. Also from the article you will learn about what features are inherent in this tool, whether it has side effects, analogues and contraindications.
Form of the drug, its composition, description and packaging
In what forms does the Bifosin drug go on sale?
- Cream. Instructions for use states that the main substance of this drug is bifonazole. As additional components, macrogol 400, propylene glycol and macrogol 4000 are added to it. The colorless 1% cream for external use has a uniform structure and is available in aluminum tubes packed in cardboard boxes.
- White or light cream powder (may be grayish) for external use. Its active element is bifonazole, and excipients are corn starch, zinc oxide and talc. It goes on sale in plastic cans.
- Lightly colored or colorless clear solution for external use. Its active ingredient is bifonazole. As for additional substances, they include macrogol 400. You can purchase this form in dark glass bottles (droppers).
- Spray "Bifosin." Instructions for use states that this drug goes on sale in the form of a 1% clear and colorless liquid for external use. Its active substance is bifonazole, and propylene glycol, macrogol and isopropanol are used as auxiliary elements. This form can be purchased in polymer bottles equipped with a spray.
Features of the drug
What properties are inherent in all forms of the drug "Bifosin"? Instructions for use reports that it is an antifungal agent. The main target of this medication is the membrane components of such fungal cells as ergosterols.
Bifonazole, which is part of this drug, is able to suppress the processes of ergosterol synthesis at two stages of its formation. As a result of the functional and structural effects, the cell membranes of the fungal cell are damaged.
What bacteria is Bifosin effective against? The instruction for use states that this medication can adversely affect dermatophytes (has a fungicidal effect on trichophyton, epidermophyton and microsporum), as well as yeast and mold fungi (it has a fungistatic effect).
It should also be noted that the medication in question does not affect enterococci in any way.
The minimum amount of drug that has an effective antifungal effect is 5 ng / ml.
The concentration of the drug at 20 ng / ml contributes to the fungicidal effect (in relation to Candida mushrooms), and in lower doses to the fungistatic effect.
Pharmacokinetics
Is the external drug “Bifosin” absorbed? Instructions for use (the price of the drug is presented below) indicates that this medication penetrates well into the layers of the skin. Its absorption is 0.6-0.9%. In this case, the concentration of bifonazole in the blood is not determined.
After applying cream or other forms of the drug (after 6 hours), the percentage of bifonazole in the skin is many times higher than the minimum effective concentration for harmful effects on fungi.
The duration of the active substance in the skin is 36-72 hours. A medication is withdrawn after 19-32 hours, depending on the density of the dermis.
Indications
In what cases is the external drug “Bifosin” prescribed? Instructions for use, reviews of dermatologists report that this medication should be prescribed only by a narrow specialist.
As a rule, it is used to treat skin that has been affected by dermatophytes, mold and yeast-like fungi, these are:
- dermatomycosis of smooth skin ;
- pityriasis versicolor;
- fungal infections of the hands and feet;
- superficial candidiasis ;
- dermatomycosis on the head (use only powder, solution or spray);
- erythrasma.
Contraindications
There are not many contraindications for this drug. These include:
- period of breastfeeding;
- hypersensitivity to drug substances.
It should also be noted that with special care this medication is prescribed for babies up to a year and pregnant women in the first trimester.
The drug "Bifosin": instructions for use
The drug for external use should be used once a day, at bedtime.
A cream, powder or solution is applied in a thin layer to the affected area of ​​the skin and rubbed well. As for the spray, it is sprayed in an amount sufficient to thoroughly moisten the integument. Also, the medication is applied to adjacent areas. What is the dosage?
To treat a palm-sized skin area, it is necessary to use a strip of cream 0.5-1 cm long or a few drops of a medicinal solution (about 3 ml).
In order to achieve a satisfactory therapeutic effect, treatment should take place continuously for the following periods:
- with erythrasma and pityriasis versicolor - 2 weeks;
- with mycosis of the interdigital areas and feet - 3-4 weeks;
- with dermatomycosis of smooth skin - 2-3 weeks;
- with dermatomycosis of the head - 4 weeks;
- with candidiasis of the skin (superficial) - 2-4 weeks.
After eliminating all the symptoms of mycosis, the drug continues to be used for prophylaxis, using it once a day for two weeks.
Side effects
What are the side effects associated with the use of the drug "Bifosin"? The instructions for use state that this product can cause local reactions such as skin irritation, hyperemia, burning sensation, eczema, allergic reactions, vesicular rash, skin itching, maceration, allergic dermatitis and desquamation.
The listed phenomena are reversible and disappear immediately after the cessation of treatment.
Overdose cases
What are the symptoms of an overdose when used improperly? Experts say that low systemic absorption of this drug makes overdose impossible.
Special recommendations
In the absence of a therapeutic result, you must consult a doctor and undergo an additional examination. In accordance with the data of the analyzes, the treatment is adjusted.
Avoid contact with the external preparation in the eyes and other mucous membranes.
The use of the drug in infants (up to one year) is possible only under the supervision of a pediatrician.
Cost and analogues
The price of this tool depends on the form of its release and can vary between 40-120 rubles. As for analogues, the following agents are referred to them: “Bifasam”, “Mikospor”, “Bifonazole”, “Mifungar”, “Ecodax”, “Dermazol”, “Amiklon”, “Travogen”, etc.
Reviews
Now you know what the medicine "Bifosin" is. Cream (instructions for use, price, reviews are described in this article), as well as other forms of this drug are often prescribed for fungal skin lesions. Patients claim that this tool does an excellent job of the task. After a few days of treatment, the fungal manifestations completely disappear.
Another advantage of this drug is its low cost.