How does the drug "Nandrolone Decanoate"? You can find reviews about this tool at the very end of the article. You will also learn about the form in which this medication is made, how it should be used, whether it has contraindications, analogues and adverse reactions.
Composition, description, packaging and form
Nandrolone Decanoate is sold as an oily solution for injection. A transparent preparation of white color is available in ampoules of 10 pieces in a cardboard box. Its active substance is nandrolone. Isopropyl and benzyl alcohols, as well as sunflower oil, are used as auxiliary components.
Pharmacodynamics
What is the drug "Nandrolone Decanoate"? The instruction says that this is a drug related to prolonged-acting anabolic steroids. After the drug enters the systemic circulation, it interacts with receptor proteins that are located on the surface of target organs. As a result, a complex compound is formed.
The medication in question is able to stimulate the synthesis of ribonucleic and deoxyribonucleic acids, enhance tissue respiration and phosphorylation in muscles. As a result of this effect, the muscle mass of a person increases, and his body fat is also actively burned.
Taking the drug promotes the accumulation of ATP and creatine phosphate, which accelerates the growth of male genital organs and stimulates the formation of secondary sexual characteristics.
Drug properties
What properties does the Nandrolone Decanoate medication have? The description attached to the drug indicates that it is able to stimulate spermatogenesis, male and female sebaceous glands.
Anabolic effect is actively manifested within a week after the start of injections. In the integumentary and glandular epithelium, as well as in the muscles and bones, reparative processes are activated. In addition, the completeness increases and the rate of absorption of amino acids from the small intestine increases. This effect is especially noticeable when eating protein foods.
Pharmacokinetics
As a result of treatment with this drug, the synthesis of K-dependent blood coagulation factors in the liver tissue is impaired. Blood lipid parameters also change.
Due to the reabsorption of sodium and fluid in the kidneys, this agent often causes edema.
After intramuscular injection of 100 mg of an oily solution, its highest concentration in the blood is noted after 7-12 days. The bioavailability of the drug is 100%.
In the body, the drug is metabolized in the liver with the formation of 17-ketosteroids. Withdrawal of the drug is carried out with urine and feces. Its half-life is 7 days.
Indications for use
Why is Nandrolone Decanoate prescribed? This tool is effective in:
- anemia, which occurs against a background of kidney disease, myelosclerosis, myelofibrosis and myeloid bone marrow aplasia;
- diabetic retinopathy;
- Werdnig-Hoffmann syndrome;
- inoperable carcinoma of the mammary glands (in women), after ovariectomy and in the postmenopausal period.
It should also be noted that this medication is used for:
- elimination of anemia, which was caused by metastases from malignant neoplasms, various drugs and salts of heavy metals;
- increase in catabolism and generation rate in chronic infectious diseases, as well as after serious injuries, operations and with steroid myopathy;
- elimination of hypocalcemia in postmenopausal and senile osteoporosis, as well as after treatment for corticosteroids;
- growth stimulation of children with a lack of growth hormone.
Among other things, the drug in question is often prescribed to people with progressive muscular dystrophy.
Contraindications
The drug "Nandrolone Decanoate" is contraindicated for use in the following conditions:
- with ischemia;
- with allergies to the active substance;
- during breastfeeding;
- people with prostatic hypertrophy or carcinoma;
- during pregnancy;
- with malignant breast tumors in men;
- people with severe atherosclerosis;
- the fairer sex with breast carcinoma, including with hypercalcemia;
- with a tendency to form edema due to heart failure, as well as due to acute or chronic diseases of the kidneys and liver (with nephritis);
- people suffering from alcoholism, as well as patients with alcoholic damage to the kidneys, liver or heart.
How to take Nandrolone Decanoate?
The course of treatment with this agent should be prescribed only by a doctor. According to the attached instructions, the oily solution must be administered deeply, intramuscularly.
The dosage of the drug, as well as the duration of therapy, depends on the indications:
In the treatment of anemia, this medicine should be combined with iron supplements. The dosage for men should be 100-200 mg once a week. As for women, they are recommended to use 50-100 mg of the drug with the same multiplicity.
The duration of therapy is determined by the attending physician.
Most often, the drug "Nandrolone Decanoate" is used as an anabolic agent. Men need to enter it in an amount of not more than 200 mg once every 7-28 days. Women should reduce this dose to 100 mg.
If the drug is used for children 2-14 years old, then dosages of 25-50 mg should be used. In this case, the frequency of administration is the same as in adults.
The course of therapy is 12 weeks. After 2 months, the injection can be resumed.
To build muscle mass, treatment with Nandrolone should be combined with a protein diet.
Side effects
Does the drug Nandrolone Decanoate cause adverse reactions? Athletes' reviews state that if the recommended dosages are observed, undesirable effects are not observed.
Most often, adverse reactions develop when taking large doses of the drug. In this case, the drug may cause:
- vomiting, abdominal pain, abnormal liver function (eg, jaundice), nausea;
- progression of atherosclerosis, iron deficiency anemia, peripheral edema;
- leukemia-like syndrome;
- bleeding, blood clotting disorders;
- hepatic purpura;
- disturbances in breathing, headaches, vomiting with blood, darkening of feces and other signs of hepatonecrosis;
- violation of spermatogenesis, hepatocellular carcinoma ;
- staining of urine in a dark color, pain in the right side, yellowing of the skin, discoloration of the stool and other signs of cholestatic hepatitis.
Representatives of the weaker sex on the background of an overdose may manifest:
- hypercalcemia;
- dysmenorrhea or amenorrhea;
- clitoris growth, increased hair growth, voice changes.
The nature of side effects in men depends on age:
- In the prepubertal period, phenomena such as penis growth, skin rashes, accelerated formation of secondary sexual characteristics, cessation or acceleration of growth, acne, and hyperpigmentation are observed.
- In the post-puberty period, gynecomastia, an increase in the frequency of urges to urinate, as well as an increase in the density of the mammary glands and their sensitivity are noted.
- In older men, this drug can cause carcinoma or prostatic hypertrophy.
Drug interaction
Before taking the drug in question, you should definitely consult a doctor. It is also necessary to study the attached instructions. It says that this medication may have such a trade name as Retabolil.
Nandrolone Decanoate enhances the effects of insulin, indirect anticoagulants, antiplatelet agents, and diabetes medications for oral use.
Means containing sodium, corticotropin, mineral corticoids, GCS increase water retention in the body, thereby increasing the likelihood of acne and edema.
The medication "Nandrolone Decanoate" noticeably weakens the effect of growth hormone, as well as its derivatives. When combined with hepatotoxic drugs, it protects the liver.
Special recommendations
Despite the fact that this drug does not have androgenic properties, it should be recommended to women with special care.
Treatment with this drug can be combined with radiation therapy, as well as with the use of cytostatics and glucocorticosteroids.
Particular care must be taken with glaucoma, epilepsy and migraine. During therapy, periodic monitoring of the state of the prostate gland, intraocular pressure and liver function tests is required.
In the presence of a progressive malignant tumor, the duration of treatment is determined by the doctor and depends on the patient's condition.
Analogues of the drug and its price
What nandrolone-based drugs are known to you? You can replace the medication in question with the following means: Nandrolone D, Phenobolin, Retabolil, Deca-Durabolin.
"Nandrolone Decanoate" in the form of an oily solution in ampoules can be purchased for 2000 rubles.
Opinions about the drug
Reviews about this tool are left mainly by people involved in sports who want to improve their physical data, accelerate the growth of muscle tissue and reduce fat content.
According to the athletes, Nandrolone Decanoate is well tolerated. However, in some cases, it can cause headaches, allergic reactions, and back pain.
Representatives of the weaker sex rarely use this drug. However, they note that in small doses the androgenic effect does not occur.