In this article, we will consider the description and instructions for use with "Triptorelin". Triptorelin is considered the most effective and effective substance to combat even the most severe pathologies of the reproductive system in both men and women. Based on this substance, a number of drugs are produced. Triptorelin has quite a few opponents and supporters.
Release Forms
To date, the drug is made only in the form of a lyophilisate for solutions. There are several varieties of the drug, depending on the concentration of triptorelin. At a dosage of 11.25 mg and 3.75 mg, the substance is used for intramuscular administration. A dosage of 0.1 mg is used for subcutaneous administration.
Structure
In drugs, the main active ingredient is triptorelin pamoate. The substance has a pronounced pharmacological and therapeutic effect. Saline or mannitol acts as a solvent for the lyophilisate, depending on the dosage of the drug.
The properties
According to the instructions for use, triptorelin is, from a biological point of view, a synthetic analogue of the hormone GnRH, which is produced by the hypothalamus. This hormone acts on the pituitary gland, which, in turn, is responsible for the production of sex hormones. Thus, the process of regulating the work of the female and male organs of the reproductive system, namely, the testicles, uterus, ovaries and prostate gland, occurs.
"Triptorelin" has a pronounced antigonadotropic and antitumor effect. It has an effect in the treatment of certain pathologies of the organs of the reproductive system. In case of infertility while taking “Tryptorelin”, the synthesis of luteinizing hormone is suppressed, which negatively affects the ovulation process. This greatly increases the chance of conceiving a child.
When prostate cancer is detected, the use of "Tryptorelin" resets the level of testosterone in the male body, which can increase the effectiveness of anti-cancer therapy and prevent the growth of tumors.
Indications
As indicated by the instructions for use with Triptorelin, its effect on the body directly depends on the concentration of the drug used. Injections with a dosage of 0.1 mg are indicated in the treatment of infertility. This concentration of tryptorelin promotes activation of the ovaries, and also stimulates the ovulation process in vitro fertilization.
3.75 mg of tryptorelin is used in the treatment of prostate cancer in men, as well as with uterine fibroids, endometriosis of the genital and extragenital type, premature puberty and IVF protocols.
A dosage of 11.25 mg of triptorelin is prescribed only in extreme cases, when it comes to severe forms of prostate cancer, as well as in the chronic form of endometriosis. When using the drug, the patient's chances of a full recovery significantly increase.
Also on sale, you can find a long-acting drug "Triptorelin long." It is better to familiarize yourself with the instructions for use in advance.
Contraindications
Contraindications for the use of "Triptorelin" are due to the patient's condition, as well as the individual characteristics of each organism.
In the case of men, a contraindication for the use of triptorelin-based drugs will be:
- Hormone-independent form of prostate cancer.
- Testicle removal performed.
For women, contraindications are as follows:
- Pregnancy.
- Lactation.
- Polycystic ovary.
The drug is used with caution in osteoporosis and against the background of individual intolerance.
Instructions for use "Triptorelin"
The frequency of administration of "Tryptorelin" and the duration of therapy depend on the indications for its use. In short and long IVF protocols, the drug is used in a dosage of 0.1 mg under strict medical supervision. "Triptorelin" is administered in one ampoule daily from the second day of the menstrual cycle. The duration of use depends on the individual characteristics of the woman's body.
At a dosage of 11.25 mg, the drug is administered once every 90 days. Tryptorelin in such a dosage can be administered to men at any time; in the case of women, the use of the drug is allowed only in the first five days of the menstrual cycle. The duration of therapy is one or two injections. Instructions for use with the drug "Triptorelin" confirms this.
The most common use is 3.75 mg. Injections are administered once every 30 days. This is enough to provide the body with active substances.
- Prostate cancer. The drug is prescribed for administration once every four weeks. In this case, a dosage of 3.75 mg is used. The duration of administration depends on the positive result obtained during treatment.
- Endometriosis "Triptorelin" is administered in the first five days of the menstrual cycle. The next injection is carried out after four weeks. In total, the duration of treatment should not exceed six months. You can not combine the use of "Triptorelin" with oral contraceptives. The substance provokes an artificial menopause during the treatment of endometriosis. The cycle is restored after the cessation of injection. In a recurring form, a second course of "Triptorelin" is not performed.
- Premature puberty. For adolescents, the drug is prescribed once every four weeks. A single dosage should be determined by the attending physician taking into account the weight and age of the patient. With a weight of more than 20 kg, 3.75 mg is administered, with a lower body weight, a single dosage is halved. The course of treatment depends on the rate of normalization of the patient's condition.
- Uterine fibromyoma. Injections are administered once a month for five days from the start of the menstrual cycle. Therapy is carried out for no more than three months.
What else does the instruction for use with Triptorelin tell us?
Side effects and overdose
Against the background of injection, the following adverse reactions are possible:
- Nervous system: disturbed sleep, headache, mood swings, depression, irritability, fatigue, asthenia, visual impairment, paresthesia.
- Gastrointestinal tract organs: constipation, nausea, diarrhea, obesity or anorexia, increased activity of hepatic transaminases, hypercholesterolemia.
- Genitourinary system: in men, there is a decrease in libido, flushing of the face, impotence, gynecomastia, a decrease in the size of the testicles; women may have dryness of the vaginal mucosa, spotting, pain during intercourse, decreased libido, hot flashes.
- Musculoskeletal system: pain in the back, myalgia, demineralization of bone tissue.
- Allergy: skin rash, hyperemia, itching, anaphylactic shock.
- Others: anemia, swelling of the legs, transient hypertension.
To date, there have been no cases of overdose of drugs based on triptorelin. Patients report the substance as relatively safe. Drugs do not affect the ability to drive a car and concentration in general.
This is indicated in the instructions for use with "Triptorelin" 3, 75. Reviews are presented below.
Analogs
The modern pharmaceutical market is ready to present only a few drugs based on triptorelin:
- Decapeptil.
- "Diferelin".
- Triptorelin Long.
In addition, in pharmacies you can find drugs similar in effect to the body, which include another active substance:
- "Buserelin."
- Zoladex.
- "Lucrin Depot."
- Eligardt.
Instructions for use with the analogues of "Triptorelin" are not considered in the article.
Reviews
Reviews on drugs based on triptorelin are rather controversial, from extremely negative to enthusiastically positive. The impact on the patient's body of a given substance is individual and not always predictable. Women in most cases note a positive trend on the background of injections of triptorelin. However, almost everyone notes the development of undesirable reactions, especially on the part of the hormonal system, such as irritability, fatigue, weight gain, etc. But all patients agree that such a complex drug therapy is preferable to surgical intervention.
Men are no less controversial about the use of triptorelin-based drugs. A significant disadvantage of therapy with this substance is its cost. The price of seven bottles on average varies, starting from 5 thousand rubles. However, when used once a month, many find this price acceptable, especially given the positive dynamics in treatment.
Thus, the main disadvantages of the drugs are called frequent adverse reactions, as well as low efficiency in certain cases.
We reviewed the instructions for use with "Triptorelin" 3.75 mg.