"Grandaxinum" has been known all over the world for a very long time and has established itself as an effective drug for the treatment of neurosis, autonomic and disturbing manifestations of other diseases. With a prescription or not, “Grandaxin” is dispensed in pharmacies, it will become clear if you understand its properties, indications, contraindications and side effects.
Active substance
"Grandaxin" is a drug with the active substance tofisopam, which is obtained by improving the diazepam molecule. As you know, “Diazepam” is a tranquilizer of benzodiazepine, which is a serious controlled drug, so the answer to the question of whether you need a prescription for “Grandaxin” will be positive. But unlike his older brother, thanks to the chemical modifications, Grandaksin is not addictive and does not cause serious side effects. Therefore, you will need the usual white prescription for Grandaxin, which not only a psychiatrist and psychotherapist can prescribe.
The properties of tofisopam are:
- The anti-anxiety effect, that is, the removal of nervous tension, the relief of fear, internal trembling and anxiety.
- The vegetative stabilizing effect is due to balancing the work of the parasympathetic and sympathetic parts of the autonomic nervous system, which helps to correct disorders in the form of tachycardia, drops in blood pressure, sweating, stool disorders, nausea, abdominal pain, and urination disorders of functional origin.
- Moderate stimulating activity helps to fight apathy, weakness, asthenia, depression, lack of energy.
Indications for appointment
The drug is prescribed for the following pathologies:
- Neurotic disorders accompanied by anxiety, anxiety, asthenia (anxiety-phobic disorders, neurasthenia, anxiety depression, panic attacks).
- Somatoform autonomic disorders (somatoform autonomic dysfunction, somatoform pain disorder, hypochondriacal disorder).
- Adaptation disorders, accompanied by anxiety and low mood.
- In gynecological practice for the relief of premenstrual syndrome and menopause (increased blood pressure, sweating, tachycardia, flushing, irritability).
- In neurological practice, to eliminate tension headache, dizziness, fainting conditions associated with anxiety disorders, relieve manifestations of radiculopathy and osteochondrosis.
- In cardiological practice, to get rid of tachycardia, hypertension and arrhythmias of a functional nature that arise when the imbalance of the nervous system.
- In narcology to alleviate the withdrawal of alcohol and other psychoactive substances.
Thus, a specialist on any profile can write a prescription for Grandaxin, depending on the indications for use.
Dosage regimen
The drug is taken orally, regardless of food. The dose depends on the disease and is selected individually by the doctor. On average, 1-2 tablets of 50 mg are prescribed from one to three times a day. The maximum can be taken 6 tablets of tofisopam per day, which is 300 mg. Perhaps situational use of the drug for 1-2 tablets.
It is only the doctor who decides whether Grandaksin is to be prescribed or not, but according to the rules, the pharmacy must require a form with a seal.
Contraindications
What could be the reason to refuse to accept funds:
- Strong motor overexcitation, aggressive behavior, severe depression.
- Decompensated cardiopulmonary failure.
- Attacks of sleep apnea.
- Pregnancy in the first trimester (12 weeks).
- Lactation.
- Conditions in which lactose is not tolerated, present in the tablet as an auxiliary component.
- Individual intolerance to benzodiazepines or tofisopam.
- Joint administration with cyclosporine, sirolimus, tacrolimus.
If at least one of the above diseases or conditions is present, there is no permission to take the drug. "Grandaxinum" according to the prescription or in stationary conditions is appointed after careful questioning of the patient.
Side effects
The drug is well tolerated, but in rare cases, the following undesirable effects were noted, which were manifested more often when using large doses of the drug:
- Headache, increased irritability, impaired falling asleep, motor excitement, confusion of consciousness, the occurrence of seizures in epileptics.
- Anorexia, gas formation, constipation, nausea, dry mouth, jaundice.
- Painful sensations in the muscles associated with their tension.
- Allergic urticaria, pruritus, rash similar to scarlet fever.
- Inhibition of respiratory function.
If side effects occur, consult a doctor immediately.
Use in pregnant women
The drug should not be used in pregnant women in the first trimester, as it can harm a developing baby. After 12 weeks, “Grandaxin” can be prescribed only when the benefits of taking it for the mother will significantly prevail over the risk to the fetus.
The active substance passes into breast milk, so during lactation you should refrain from taking the drug.
special instructions
Grandaxinum is prescribed with caution in patients with the following diseases:
- Diseases of the pulmonary sphere (chronic course, respiratory distress syndrome in the stage of decompensation, acute respiratory failure).
- Liver diseases (cirrhosis, severe hepatitis, liver tumors). In this case, an increase in adverse events to the medication is possible.
- Persons with kidney failure should reduce the dose by half, because the active substance is excreted by the kidneys.
- Diseases of the nervous system (epilepsy of various origins, organic brain pathologies, including severe atherosclerotic lesions of the brain vessels).
- Angle-closure glaucoma due to the risk of increased intraocular pressure.
- Elderly people should adjust the dosage, reducing it by half.
- With psychoses accompanied by motor reactions, obsessive disorders and phobias in the acute stage, as well as in the depressive phase, treatment with Grandaksin alone will not bring the desired effect, but can only aggravate the situation. Therefore, it is necessary to combine it with more pathogenetic agents.
Driving vehicles and working at height with the use of tofisopam is not prohibited, since the drug does not have a sedative and inhibitory effect on the central nervous system.
Drug interactions
Grandaxinum is forbidden to be used together with tacrolimus, cyclosporine, sirolimus, as these medicinal substances undergo chemical transformations using the same enzyme, which can lead to a significant increase in their blood content.
Medications that affect brain cells by changing the functioning of the central nervous system (anesthetics, anesthetics, painkillers, antidepressants, sedatives, histamine H 1 receptor blockers, hypnotics, antipsychotics) can increase their effect, which can lead to an increase in side effects. reactions.
Acceleration of transformations of the active component under the influence of inducers of enzymatic liver activity (ethyl alcohol, barbiturates, epilepsy drugs) causes an increase in their amount in blood plasma, which weakens the therapeutic effect of the drug. Therefore, drinking drops with phenobarbital ("Corvalol"), alcohol in the treatment of "Grandaxinum" is prohibited.
Means that kill a fungal infection, containing itraconazole and ketoconazole as the main substance, slow down the metabolic reactions of tofisopam, which causes its accumulation in plasma and increases the risk of side effects.
Strengthening the action of the drug is possible under the influence of some drugs from pressure (clonidine, calcium channel blockers).
To a small extent, without clinical manifestations, beta-adrenergic blocking drugs can reduce the conversion of the drug in the body.
When taken with Digoxin, its amount in the blood may increase, which should be considered in patients with cardiac pathology.
"Warfarin", taken for liquefaction, can interact with "Grandaxinum", therefore, the coagulogram of patients should be carefully monitored.
Antacids that reduce gastric acidity may interfere with normal absorption of the drug.
Omeprazole and Cimetidine, used in gastroenterological practice, reduce the metabolic transformations of Grandaxin, which may affect the occurrence of negative effects.
Combined oral contraceptives reduce the metabolism of the drug, which should be considered when choosing a dose.
Grandaxin: Prescription or Not?
By law, 70% of drugs registered in the Russian Federation must be dispensed according to the prescription form. The drug is a derivative of benzodiazepine. Therefore, "Grandaxin" should not be dispensed without a prescription. This is indicated in the instructions for the drug. For over-the-counter leave the pharmacy faces a fine. In addition, the prescription for the drug with the active substance tofisopam should remain in the pharmacy and must be accounted for in order to control the number of packages sold.
It is possible to purchase “Grandaxin” without prescriptions in a pharmacy via the Internet, but when delivering the goods to patients' homes, they may also require a prescription form. These rules are spelled out on the site when placing an order.
Grandaxin Sample Recipe
According to the order of the Ministry of Health of the Russian Federation No. 403n (07/11/2017) “On the approval of the rules for dispensing drugs,” the delivery of medicines from pharmacies has changed somewhat and the list of prescription drugs has expanded. On the drug "Grandaxinum", the Latin prescription should be prescribed only by a doctor in the form No. 107-1 / . Any initiative is not legal. The form must contain the patient’s last name and initials, his age, doctor’s name and initials, discharge date, type (adult or child), number of tablets, method and mode of administration, prescription validity period, doctor’s personal seal and signature, and the institution’s seal where the specialist works.
Reviews
According to statistics on patients' responses to the drug "Grandaxin", from 80 to 90% of people who took this medicine have a positive attitude towards it.
Doctors of various specialties prescribe medication with pleasure because of high efficiency, a wide range of indications and good tolerance of the active substance.
Studying the reviews of patients, it should be noted that to buy "Grandaxin" without prescriptions in Moscow is quite simple. This applies to a large number of other medicines that must be prescribed. Such violations lead to unreasonable and uncontrolled taking of drugs, which entails an increase in the number of poisonings, side effects and overdoses.