Non - hormonal (non-steroidal) anti-inflammatory drugs (NSAIDs) are used widely enough to suppress inflammatory processes in the body. One of the very first drugs in this group is acetylsalicylic acid (aspirin). NSAIDs are available in various forms. Pills, capsules, as well as non - steroidal anti - inflammatory ointments are quite popular . The latter, in particular, include Diclofenac.
Non-steroidal anti-inflammatory drugs are endowed with three main properties: antipyretic, actually anti-inflammatory and analgesic.
To date, medicines from this group are classified in accordance with the chemical structure and are derivatives:
- Propionic acid (Naproxen, Ibuprofen and others).
- Fenamic acid.
- Pyrazolone.
- Acetic acid (indomethacin, diclofenac and others).
- Oksikama (Piroxicam and others).
- Salicylic acid (sodium salicylate, acetylsalicylic acid, salicylamide).
Nonsteroidal anti-inflammatory drugs inhibit platelet aggregation.
The therapeutic properties of NSAIDs are explained by the blockade of the enzyme cyclooxygenase2, as well as a decrease in prostaglandin synthesis.
Nonsteroidal anti-inflammatory drugs are prescribed for pain of various origins (head, musculoskeletal and other types), inflammation in the musculoskeletal system, fever, rheumatic diseases.
As practice shows, when revealing an insufficient therapeutic effect from taking one NSAID, replacing it with another medication of the same group is not practical, doubling the dosage can only lead to a slight (clinically insignificant) increase in exposure.
Possible side effects from the use of these medications include:
- intestinal disorders;
- hemorrhoidal bleeding;
- peptic ulcer in the duodenum and stomach;
- swelling of the limbs (lower) and face;
- increase in blood pressure;
- allergies.
In order to reduce the risk of negative reactions, specialists when choosing medications try to prescribe non-steroidal anti-inflammatory drugs of selective effect. According to doctors, these funds have a minimal negative effect on the digestive tract. In some cases, if necessary, NSAIDs can be taken in combination with antiulcer drugs.
It is also possible to prevent side effects when choosing the right regimen and dosage. It is recommended to take non-steroidal anti-inflammation medications with food. In this case, the frequency is chosen such that accumulation in an excessive concentration of NSAIDs does not occur.
According to experts, these medications affect the symptoms of the disease, not eliminating the cause of its occurrence. Therefore, one should not forget about the means aimed at eliminating the primary mechanisms of the development of pathology.
If the patient is found to be intolerant to NSAIDs, medicines are replaced with drugs of other categories. Often in such cases, a combination of anti-inflammatory and analgesic is selected .
There are certain rules for taking NSAIDs:
- Capsules or tablets should be washed down with plenty of water (at least a glass). Thus, the destruction of the gastric mucosa is prevented. After taking it for 20-30 minutes, you should not go to bed.
- It is not recommended to take two different drugs on the same day. Otherwise, side effects may increase without increasing effectiveness.
- Before using any medication, you should carefully study the instructions.