Ksefokam Rapid tablets produced by the Danish pharmaceutical company Takeda Pharma and the German company Nycomed belong to the class of non-steroidal drugs intended for stopping inflammatory processes. On average, for one package in pharmacies they ask 300 rubles or more.
What's on sale?
Ksefokam Rapid is available in tablet form. The active substance is the core of the capsule, and the outer shell is made in the form of a thin film that simplifies the administration of the drug. Each instance is convex on both sides, round. The hue varies: there are both completely white tablets and light yellow ones. Manufacturers unpack tablets in blisters for 6-10 copies. On the pharmacy shelves are cardboard boxes containing Ksefokam Rapid tablets, instructions. The exact number of servings of the drug must be indicated on the outside of the package. It also says the name of the drug, the manufacturer that released it, as well as the active substance on which the drug is based, its content in one tablet.
Each tablet of the Xefocam Rapid preparation contains the active component of lornoxicam in an amount of 0.008 g. Additionally, the following auxiliary compounds were used by the manufacturer:
- calcium stearate, hydrogen phosphate;
- sodium bicarbonate;
- cellulose;
- hyprolosis;
- hypromellose;
- titanium dioxide;
- talc;
- propylene glycol.
Before starting use with a full list of ingredients, it is especially important to familiarize people with allergic reactions, hypersensitivity to any substances used in the pharmaceutical industry. This will reduce the risk of a negative response of the body to the prescribed therapy. All possible allergic reactions must be warned by the prescribing physician. It is important to inform him of previous cases of allergies caused by any drugs, even if they did not belong to the class of non-steroidal anti-inflammatory drugs.
In addition, Ksefokam Rapid is available in the form of a substance for injection.
Pharmacology
Clinical trials have proven that the medication has a pronounced anti-inflammatory effect, relieves pain. Lornoxicam, on which the Xefocam Rapid tablets are based, has a particularly complex effect on the body. The compound is able to inhibit the first and second types of COX isoenzymes, therefore, it controls the activity of prostaglandins production in the body, thereby facilitating the patient's condition, stopping local manifestations of inflammation.
In the instructions for the use of Xefocam Rapid tablets, the manufacturer draws attention to the inhibition of the release of oxygen free radicals from certain types of white blood cells. The advantage of tablets in the analgesic effect, which does not have mechanisms common with narcotic substances. Studies have shown that pills and injections do not provoke addiction, and abandonment of them does not become a cause of withdrawal. The drug does not have a negative effect on the respiratory system, does not show effects on the central nervous system, similar to those characteristic of opiates.
Kinetics
The main component of Xefocam Rapid tablets is absorbed shortly after ingestion. The processes are mainly localized in the digestive tract. The highest concentration in the circulatory system is usually observed after one hour, sometimes two hours after the ingestion of tablets. If you use tablets during the meal, the maximum rates are reduced by almost a third, and the time period required to achieve them increases to 2.3 hours. It is possible to lower the quality of the absorption process by 20%.
Lornoxicam shows bioavailability parameters close to 100% (in some patients - 90% and slightly higher). The instructions for the use of Xefocam Rapid tablets indicate the absence of the effect of the first passage of the liver structures.
Half-life requires three to four hours. Lornoxicam enters the blood plasma in two forms: the original, hydroxylated metabolic product. The metabolite does not have a pronounced pharmacological activity. The ability to enter into strong bonds with plasma proteins is estimated at 99% and does not depend on the concentration of the active compound.
A study of the processes that occur when taking Xefocam Rapid 8 mg tablets shows that metabolism covers the entire dose taken, and the product that is formed does not show pharmacological activity. About a third of the total amount is excreted by the kidneys, the path of elimination of the other volume is the liver. Transformation processes proceed with cytochrome. If genetic polymorphism causes a slow metabolism, there is no accumulation of the active compound in the plasma component of the blood. The substance does not exhibit induction on liver enzymes. Even prolonged use of Xefocam Rapid tablets (according to the instructions for use!) In compliance with the dosages does not lead to a cumulative effect.
If you use the drug and antacids, the kinetics of lornoxicam does not change. At an advanced age, clearance is on average lower by one third than in younger patients. No changes in kinetics were detected in conditions of impaired functionality of the kidneys and liver.
When will it help?
In the reviews and instructions of "Xefokama Rapid" it is indicated that the drug is used for injuries, as well as after surgery, if you are concerned about severe pain. Those taking the tablets noted that the drug has a pronounced and quick effect, therefore it really effectively eases the condition of patients after the first use. True, patients also noticed that they took the drug under the supervision of a doctor. Individuals who have used self-medication at home with pills or injections are more likely to complain about the side effects of this medication than recognize the benefits of its use.
Many in the responses confirm that the drug is adequate, fully justified by its quality price. Reviews, instructions for use "Xefocam Rapid" confirm that the tool alleviates the condition of persons suffering from:
- algodismenorea;
- lumbar ischialgia.
The doctor may prescribe this medication if osteoarthritis, rheumatoid arthritis is established. The main source of problems, the pills will not be eliminated, but the symptoms of the disease will be significantly relieved.
The instruction “Ksefokam Rapid” is recommended for use strictly under the supervision of a doctor. Self-administration of a drug containing lornoxicam is strictly contraindicated, since it has side effects. In addition, the drug cannot be used in certain cases.
Contraindications: what does the instructions for use say?
The description of Xefocama Rapid by the manufacturer includes a list of cases in which tablets are strictly prohibited. The following cases and conditions belong to absolute contraindications:
- bleeding in the digestive tract;
- ulcer (acute phase, relapse in the medical history);
- cerebral hemorrhages (confirmed, suspected);
- inadequate functioning of the liver, heart, kidneys in severe form;
- thrombocytopenia (severe);
- hypovolemia;
- intolerance to the components used in the production.
The use of "Ksefokama Rapid" is not allowed for pregnant and lactating mothers, minor patients.
The manufacturer draws attention to the impossibility of using tablets if intolerance to acetylsalicylic acid, non-steroidal anti-inflammatory in the past, is established.
In addition to the absolute, there are relative contraindications mentioned in the instructions for use of Xefocam Rapid. The price of inattentive attitude to the patient in such conditions is pronounced side effects when taking the medication, therefore the drug is prescribed only if it is possible to control important vital signs of the body. Relative contraindications:
- past gastric, intestinal ulcers, bleeding;
- problems of blood coagulation;
- liver disease
- failure of the kidneys, liver, heart;
- recent surgery, especially large-scale;
- anesthesia affecting the spinal cord, as well as epidural;
- combination with diuretics;
- combination with drugs that are potentially dangerous for the kidneys;
- weight up to 50 kg;
- age over 65 years.
Accuracy requires a long course (a month or more).
Terms of use
As the patients taking the drug assure, with proper use, the price of Xefocam Rapid 8 mg (about 300 rubles per package and above) fully justifies. True, to get the maximum result, you will have to follow all the manufacturer's recommendations. In particular, tablets are consumed with plenty of water. The doctor selects a specific dosage format, focusing on the patient's condition, the body's response to lornoxicam.
On average, reviews show that “Ksefokam Rapid” shows a pronounced effect when taking one tablet per day. Much less often, the patient's condition requires two tablets. More than this should not be used.
The manufacturer draws attention to: for elderly people with normal functioning of the liver and kidneys, Ksefokam Rapid is used in the same amount as in the treatment of young, middle-aged people. Special dosage adjustment is not required.
If failure of the liver and kidneys is established, smaller amounts of medication are used in food, following the recommendations of the instructions for use. Reviews of “Xefocame Rapid” confirm that the drug shows a pronounced effect even in a reduced dose, if the patient's condition forces such restrictions to be made.
Negative consequences
About 300 rubles - this is exactly the current price of Xefocam Rapid tablets 8 mg. The price, as noted by those taking the drug, is justified, especially taking into account the effectiveness of the drug, although there were some side effects of use. The manufacturer lists all possible negative reactions of the body in the instructions. The doctor will also draw attention to them, prescribing a medication. The doctor will immediately explain exactly which negative answers require special attention, how to behave if unfavorable symptoms are bothering, in what conditions you will have to refuse to take the drug.
On average, statistics show that side effects are quite rare, only in a small number of patients, so doctors believe that quality fully justifies the price. The instruction "Ksefokama Rapid" contains a mention of the possibility of development against the background of the use of tablets:
- throat infection;
- increased duration of bleeding;
- anemia
- thrombocyte, leukopenia;
- ecchymosis;
- hypersensitivity reactions;
- digestive system disorders;
- sleep disturbances;
- oppressed states;
- weight loss;
- confusion of consciousness;
- excitement, nervousness;
- headaches;
- dizziness
- conjunctivitis.
Sometimes patients note that they are noisy in the ears, the speed and frequency of the rhythm of the heartbeat go astray, disturbances in the perception of sound, visual image. Against the background of “Ksefokama Rapid” swelling, hematomas, hot flashes and lowering of pressure, runny nose and spasm of the bronchi, as well as dyspepsia, nausea, vomiting and disturbance of the stool are possible. Some patients under the influence of the drug begin to cough or experience stomatitis, melena. When examining the liver, an increase in the activity of individual substances is possible.
It is extremely rare that patients taking pills experience impaired hepatic function, dermatitis and purpura. There is a risk of hair loss, allergic responses, necrolysis of the epidermis, myalgia and muscle spasm. Cases of asthenia and swelling of the face were quite rare. There is a risk of arthralgia, an increase in the concentration of creatinine and urea in the circulatory system.
Too much!
In any form of release (tablets or injections), the described drug can cause serious consequences if you use it in doses exceeding those recommended by specialists. The instructions for use of Xefocam Rapid (injections, tablets) indicate that an overdose can manifest itself as ataxia, convulsions, coma, vomiting and nausea, impaired liver and kidney function. Blood coagulation failures are possible.
If an overdose is established, it is necessary to immediately cancel the drug in any form, to provide the patient with first aid. If the product is used in the form of tablets, gastric lavage and the use of activated carbon are indicated. Symptomatic therapy is ongoing. The doctor chooses the means for this, assessing the patient's condition, the severity of the manifestations, their individual characteristics.
The nuances of therapy
The main difference between Xefocam Rapid and Xefocam is the area of the drug’s purpose. The composition considered in the material is designed for short-term use; it is available in one dosage form of the active compound - 8 mg. Xefocam is available in two formats - 4 mg and 8 mg, and can be prescribed for headaches or discomfort during menstruation. Xefocam Rapid is not indicated for use in such periods.
It is unacceptable to combine the drug in question and alcohol. Lornoxicam and alcohol are categorically not combined, the risk of serious side effects is growing.
To reduce the likelihood of an ulcerogenic effect, synthetic substances similar to prostaglandins, omeprazole, and H2 receptor blockers can be combined.
If an analysis is scheduled for the detection of 17-ketosteroids, it is necessary to cancel Ksefokam Rapid two days before the event.
If in the past the patient suffered bleeding, ulcerative processes in the stomach or intestines, it is necessary to regularly check these organs for relapse. If an ulcer, bleeding, medication is canceled, measures are taken to improve the patient's condition.
If renal failure is weak, quarterly the patient needs to undergo a check to monitor the functionality of the organ. For moderate abnormalities, analyzes are done every month or every two months. At deterioration of indicators "Ksefokam Rapid" cancel.
Application features
If blood coagulation disorders, liver problems are established, it is necessary to regularly check the functions of organs, to do analyzes, evaluating laboratory parameters.
If Ksefokam Rapid is indicated for a long course (from a month or more), it is important to constantly check the quality of the circulatory system, kidneys, as well as the activity of liver enzymes.
If the patient has undergone a major operation, suffers from heart failure, at the same time uses diuretics and the medication in question, or combines tablets with substances that are potentially harmful to the kidneys, studies should be done to clarify the functioning of the kidneys.
If epidural or affecting the spinal cord is anesthetized, the likelihood of a corresponding hematoma increases under the influence of the tablets in question.
The manufacturer recommends when using Xefocam Rapid tablets to refrain from work requiring increased concentration of attention and accuracy of movements, including transport management. Any potentially dangerous varieties of activity during the passage of a therapeutic course are contraindicated.
There is no confirmed information about the possibility of the influence of the active compound of the drug on the body of a woman who is carrying a child and the embryo. No studies have been conducted to identify the safety of the drug during its use by nursing mothers. In case of pregnancy, lactation, it is reasonable to abandon the use of the drug. If necessary, use painkillers to choose analogues of "Xefokama Rapid", allowed for an "interesting" position.
There is no information on the possible effectiveness and safety of the drug in question for persons under the age of majority. The manufacturer indicates the inadmissibility of its use by patients under 18 years of age.
Special occasion
If severe renal failure is established, use of the described drug is prohibited. If the functionality is impaired weakly or moderately, implicitly, you can use the drug, regularly checking vital signs. If the patient worsens, the tablets are canceled.
If severe liver failure is detected, Xefocam Rapid is contraindicated. If a disease of this organ is established, the remedy can be used, but only if it is possible to monitor the patient's condition. In particular, tablets are taken for cirrhosis, if it is possible to track changes in the patient's condition.
For the elderly, Ksefokam Rapid is permitted, but use requires caution. At the reception, the doctor will explain by what signs you can notice the negative effect of the tablets, when you urgently need to refuse them.
What to replace: analogues
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What do patients say?
Those who underwent treatment with Xefocam Rapid tablets have noted that the drug is highly effective. Many agree that the medicine fully justifies its price. The main drawback that people who use the drug pay attention to is the strong toxic effect that prevents them from using the medication for a long time.
"Ksefokam Rapid" is effective in mild to moderate pain, quickly acting. Patients recognize its effectiveness and pay special attention to the lack of addiction.
Another drawback noticed by some patients is the lack of absolute analogues. If at a certain point in time in the village in the Xefokam Rapid pharmacies is not available, it is difficult to find a replacement for the drug.
Mutual influence
At the doctor’s appointment, the patient must warn the doctor about all the medications used by him in everyday life. The doctor will take into account which drugs can interact with the active component of the Xefocam Rapid tablets, and will adjust the course, taking into account this information. Data on possible mutual influence is also mentioned in the instructions enclosed by the manufacturer in the package with the medication. In particular, the manufacturer draws attention to the fact that a combination of the considered tablets, anticoagulants and inhibiting platelet aggregation substances can cause more prolonged than usual bleeding. With the simultaneous use of sulfonylurea reaction products, there is a possibility of an increase in the hypoglycemic effect of these compounds against the background of lornoxicam.
If lornoxicam enters the body at the same time as other anti-inflammatory non-steroidal drugs, the likelihood of side effects inherent in all applicable groups increases. When combined with cimetidine, the concentration of the active component of the drug in question increases in the plasma component of the blood.
A decrease in the amount of lornoxicam in the circulatory system is possible with simultaneous ingestion with an anti-inflammatory medication:
- phenylbutazone;
- ethanol;
- antidepressants from the tricyclic class;
- phenytoin;
- barbiturates;
- rifampicin.
Depressing microsomal oxidation of the substance can cause activation of side effects of lornoxicam.
The following effects of the combination of Xefocam Rapid tablets and medications are known:
- methotrexate, cyclosporine in the blood serum are present in higher concentrations;
- reduced digoxin clearance in the kidneys;
- the concentration of lithium increases, which means the toxic effect of the compound on the patient's body;
- the effectiveness of loop diuretics decreases;
- inhibitory angiotensin-converting enzyme substances are less effective.
It's curious
Lornoxicam belongs to the class of anti-inflammatory drug compounds from the oxycam category. An analgesic effect is inherent in it, at the same time the substance stops inflammation and reduces heat. Lornoxicam differs from other oxycams in its strong effect on the foci of inflammation, as it inhibits the production of prostaglandins in the body. In our country, it has been included in the list of vital drugs since 2009.