The medicine "Metrogil" (intravenously) refers to antimicrobial and antiprotozoal agents. The active substance of the drug is metronidazole. The drug is active against a number of gram-positive bacteria, obligate anaerobes. In combination with amoxicillin acts on Helicobacter pylori. Resistance to medication is shown by facultative anaerobes, aerobic microorganisms. The drug increases sensitivity to tumor irradiation, provokes disulfiram-like manifestations, and stimulates repair processes.
The medicine "Metrogil" (for intravenous administration). Pharmacokinetics
With an infusion of 500 mg over 20 minutes, the maximum content of the drug in the blood is noted after an hour. About 30-60% of the drug is metabolized. The main metabolite has an antimicrobial and antiprotozoal effect. About 60-80% comes out with urine, with feces up to 15% of the drug is excreted.
Appointment
The drug is indicated for the treatment and prevention of infectious lesions caused by sensitive microbes. In particular, a medicine is recommended for surgical interventions in the urinary tract and in the abdominal organs. The indications should include sepsis, hepatic and intestinal amoebiasis in severe form, osteomyelitis, brain abscesses, and pelvis. The medicine “Metrogil” is prescribed (intravenously) for lesions of soft tissues, skin, bones, joint infections, gynecological pathologies. The drug is recommended for radiation therapy of tumors (as a radiosensitizing agent in cases of neoplasm resistance due to hypoxia in its cells).
Application chart
The initial dosage for patients from 12 years old is from half to one gram drip. The duration of the infusion is thirty to forty minutes. Each subsequent 8 hours, the medicine is administered at 500 mg. The infusion rate is 5 ml / min. With satisfactory tolerance after the first 2-3 infusions, jet administration is used. The duration of therapy is a week. A day is allowed no more than 4 g. Patients under 12 years of age, the drug "Metrogil" (intravenously) is prescribed according to the specified scheme in a single dosage of seven and a half milligrams / kg. To prevent complications from surgical interventions, patients from 12 years of age are prescribed from 0.5 to 1 g before the operation on the day of its operation and on the next day, 1.5 g / day. (0.5 mg after 8 hours). When used as a radiosensitizing agent, the administration is carried out dropwise at 160 mg / kg or from 4 to 6 g / m 2 of the body surface. Infusion is carried out half an hour or an hour before irradiation.
Side effect of the drug "Metrogil" (intravenously). Reviews
As practice shows, subject to the rate of infusion and the dosing schedule, undesirable effects rarely develop. According to experts, patients satisfactorily tolerate therapy. Rarely, disturbances in the activity of the gastrointestinal tract, nervous system can occur. Due to hypersensitivity, the development of an allergic reaction is likely. Some patients had convulsions, hallucinations, loss of appetite, and a taste in the mouth of the metal.