Analgin is an anesthetic widely used in our country. The popularity of this drug is explained primarily by the fact that they sell it in pharmacies without a doctor’s prescription, as well as its low cost. This medicine helps with almost any kind of pain. But besides the benefits, Analgin, of course, can bring harm to the human body. Therefore, this medicine should be drunk with caution and is advisable only on the advice of a doctor.
Pharmacology
As a result of taking "Analgin" in patients, not only the intensity of the pain syndrome decreases, but the body temperature also decreases. Also, this drug is able to have an anti-inflammatory effect. This is explained by the fact that it inhibits COX and prostaglandins.
Analgin belongs to the pharmacological group of non-steroidal anti-inflammatory drugs. In another way, such drugs are called pyrozolones. In addition to Analgin, this group includes, for example, medicines such as Baralgin, Aspirin, Optalgin, Spazdolzin.
All NSAIDs are able to have anti-inflammatory, analgesic and antipyretic effects. The differences between these drugs is only in the degree and speed of exposure to the patient's body.
These drugs are called non-steroidal because they are very different in structure from various hormonal drugs. The latter are also able to have an anti-inflammatory effect. However, they usually cause more serious side effects.
Mechanism of action
Once in the patient’s body, Analgin, like any other NSAID, begins to inhibit the COX enzyme, which is found in many tissues and is responsible for the production of all kinds of biologically active substances. Some varieties of the latter are mediators of all kinds of inflammations. Accordingly, when taking Analgin, such processes begin to regress.
Actually cyclooxygenase itself is classified into three groups - COX-1, COX-2, COX-3. Different NSAIDs can suppress each of these types. On this basis, such drugs are divided into:
Selective non-selective. This type of drug is able to affect any type of COX. However, it has the strongest effect on COX-1.
Non-selective non-selective, affecting COX-1 and COX-2.
Selective, suppressing COX-2.
"Analgin" refers to the pharmacological group of drugs of the second variety.
Pharmacokinetics
Once in the human digestive tract, "Analgin" begins to be absorbed very quickly and almost in full. Many people are interested in how long "Analgin" acts after taking the pill. It is known that the effect of the use of this medicine in patients occurs in about half an hour - an hour. Metabolic products when using this drug leave the body with urine.
Composition and form of release
The main active component of Analgin is metamizole sodium. This substance, in turn, is a pyrazolone derivative. Also in the composition of this non-narcotic analgesic include such additional substances as:
potato starch;
talc;
sodium lauryl sulfate;
calcium stearate.
The most popular form of this medicine in patients is tablets. They include 500 mg of the active substance.
Also in pharmacies and clinics, this medicine can be supplied in the form of a solution for injection. Such a liquid is packaged in ampoules of 1 and 2 ml. Sometimes in pharmacies you can also find "Analgin" candles. The drug in this form is used mainly only in pediatrics.
Indications for use
In most cases, this medicine is used, of course, as an anesthetic. "Analgin" can, of course, be used as an antipyretic. But the effect in this case will not be as pronounced as, for example, the same Aspirin. Indications for the use of this tool may be pain:
postoperative;
post-traumatic;
headaches;
rheumatic;
tooth and ear.
Also, this remedy is often used for myositis (muscle inflammation), colic, neuralgia and in many other cases. This drug is used both at home and in the hospital, usually only in emergency situations.
Pros of using "Analgin"
In addition to low price and availability, doctors and patients include the ability to:
Of course, the advantage of this medicine is also the fact that it is able to provide emergency assistance. As we found out, the answer to the question of how long “Analgin” works after administration is usually not more than half an hour.
Cons of application
Of course, this drug, like any other medical device, has disadvantages as well. The main disadvantage of Analgin is that its use can lead to the development of agranulocytosis - a change in blood, as a result of which a person's immunity decreases. In some cases, this disease can even be fatal.
Due to this shortcoming, Analgin is even banned for use in some countries, including the United States, Japan, Australia and Canada. Also, this fast-acting effective medicine, unfortunately, can negatively affect the heart, liver and gastric mucosa.
Postoperative period: when can it be prescribed
After surgery, like many other drugs of the same pharmacological group, “Analgin” is usually prescribed to patients in the form of injections. But using this drug in the postoperative period is not particularly common. It is believed that the painkiller effect is moderate. Therefore, after surgery, patients are usually prescribed stronger and more serious drugs. It can be, for example, Dexalgin, Tramadol, Ketalong, etc.
The same goes for post-traumatic pain. In this case, “Analgin” can be prescribed only in not too serious situations.
Indications for children
This tool can be used not only for the treatment of adults, but also in pediatrics. The main indication for use for children "Analgin" is high fever. The drug is used in this case, however, only when other agents are ineffective.
Also, "Analgin" for children can be used to relieve pain. However, pediatricians use this medicine quite rarely for this purpose.
Indications for the use of candles
In this form, “Analgin” in pediatrics can be used, for example, for diseases such as:
Apply candles "Analgin" for the treatment of children is allowed only from 3 months.
Are there any contraindications
In some cases, for the treatment of both adults and children, this tool can not be used. Contraindications to the use of this drug are:
Of course, you can not be treated using this drug and in the presence of hypersensitivity to any of its components. For children under the age of 3 months, this medicine should be used with caution.
"Analgin": is it possible to take the drug during pregnancy
When carrying a child, women cannot use this medicine at certain periods, unfortunately. It concerns the first I trimester and III, especially the last 6 weeks. When using this tool, it is also supposed to stop breastfeeding.
So is it possible to take “Analgin” during pregnancy for the treatment of pain? It is believed that in the second trimester of the fetus this medicine can not do any harm. However, during this period, you must drink the drug strictly at the recommended dosages.
What side effects can give
Of course, in some cases, this medicine can have a negative effect on the patient's body. Side effects "Analgin" most often causes the following:
skin rash, Quincke's edema;
with prolonged use - leukopenia, thrombocytopenia, agranulocytosis;
an attack of bronchial asthma;
pressure reduction;
impaired renal function;
oliguria;
anuria
regular jade;
proteinuria.
Also, in patients taking this medicine, it may turn red due to the release of urine metabolites.
What you need to know
Like many other drugs of the same pharmacological group, "Analgin" can not be used for self-treatment for acute abdominal pain. This medicine may distort the symptoms of a serious illness. In this case, you must consult a doctor before using the drug.
Caution should be given to people who abuse alcohol.
Interaction with other drugs
It is not recommended to use this drug simultaneously with other non-narcotic analgesics. This leads to a mutual increase in the toxic effect of drugs on the body. The answer to the question of which non-steroidal anti-inflammatory drugs can not be taken simultaneously with "Analgin" are, for example, such means as "Magnil", "Benzidamine", "Diclofenac". In combination with Aspirin, which also belongs to this group, this drug can be drunk only in critical situations.
To strengthen the harm from "Analgin" can also such drugs as:
It is not allowed to use this medicine simultaneously with:
"Phenylbutazone" and barbiturates are able to weaken the effect of this drug on the patient's body. This drug itself can enhance the effects of alcohol-containing drinks.
Injections "Analgin": instructions for use
A solution of this medication can be used for both intravenous and intramuscular injections. They inject “Analgin” in compliance with the following rules:
before administration, the drug is heated to the patient's body temperature;
intravenous injection is done at a very slow pace - about 1 ml / minute.
In the latter case, according to the instructions for use for injections, "Analgin" is supposed to be used for treatment only under the supervision of a doctor. With intravenous injections, it is necessary to monitor the patient's heartbeat, as well as his breathing.
The prescribed dosage
In most cases, the administration of this drug to adult patients is prescribed by mouth 1 tablet after meals 2-3 times a day. Dosages of "Analgin" for children, of course, are provided for different. For small patients, this drug is prescribed in an amount of 5-10 mg per kilogram of weight 3-4 times a day.
The maximum single dose of Analgin for adults is 2 tablets. A maximum of 6 tablets is allowed per day.
For more than 5 days, this drug should not be taken by adults as an anesthetic. For children, this period is three days. In pediatrics, it is recommended to use a special children's form of this drug.
In pregnant women, this medicine in the second trimester can be drunk in an amount of 0.25-0.5 g per day, not more than 2-3 per day. In the treatment of rheumatism, it is allowed to take up to 1 g per day.
What to do with an overdose of "Analgin"
This drug is used for self-treatment, of course, very widely. But of course, the dosage of "Analgin" for children and adults must be observed exactly. If the patient takes too much of this drug, he will show the following symptoms:
nausea, vomiting;
tachycardia, shortness of breath;
impaired consciousness, delirium;
cramps, paralysis.
An overdose of "Analgin" is treated by trans-probe gastric lavage or simply by inducing vomiting. Also, salt laxatives or activated charcoal can be prescribed to the patient.