What is the drug "Indapamide"? Analogues of this tool, its instructions, side effects and indications for use will be presented below. In addition, from this article you will learn about whether this medication has contraindications, what to do in case of an overdose, how it should be taken, whether it can be combined with other drugs, and what experts think about it.
The composition of the drug and its release form
In what form does this drug go on sale? In a pharmacy, it can only be found in the form of biconvex tablets coated with a white film coating.
What is the active ingredient in the drug Indapamide? Analogues of this tool (most of them) and the drug itself contain such an active component as indapamide. As for excipients, tablets include the following elements: lactose monohydrate, crospovidone, povidone K-30, magnesium stearate, talc and sodium lauryl sulfate.
Pharmacological action of the drug
What are the properties of the drug “Indapamide”, the price of which is presented at the very end of the article? This medication is a hypotensive drug. In other words, it is a diuretic and a vasodilator.
According to its pharmacological properties, the drug is very close to thiazide diuretics and is taken in violation of the reabsorption of sodium salts, which are located in the cortical segment of the Henle loop. It is able to increase the release of chlorine, magnesium ions, sodium and potassium along with urine.
Why is Indapamide prescribed? Analogues of this drug and the medication itself has the ability to block “slowed down” calcium channels in a selective way, increase the elasticity of the walls of blood vessels and lower the total vascular resistance (peripheral).
Taking this drug reduces heart hypertrophy, or rather, its left ventricle. It does not affect the amount of lipids in the blood, as well as carbohydrate metabolism, including in people with a disease such as diabetes.
The mentioned medication reduces the sensitivity of the vascular wall to angiotensin II and norepinephrine, reduces the production of stable and free oxygen radicals, and stimulates the synthesis of prostaglandin E2.
After the use of the drug, the hypotensive effect develops by the end of the 1st week of therapy. However, it persists for 25 hours (after taking one tablet)
Pharmacokinetics of the drug
Where is the medicine “Indapamide” absorbed? Instructions, reviews of specialists say that after taking the drug inside, it is almost completely and instantly absorbed from the digestive tract. According to pharmacists, its bioavailability is 93%. The simultaneous intake of food slows down the absorption rate a little, although it does not affect the volume of the absorbed active element.
The maximum concentration of the active component in blood plasma is reached approximately 2 hours after taking one tablet. The half-life of the drug is 14-25 hours. Communication with blood proteins - about 79%.
This drug passes well through the histohematological barrier (including the placental). It also passes into breast milk.
The metabolism of a drug substance is carried out in the liver. It is excreted by the kidneys (in the form of metabolites) in the amount of 60-80% and 20% - through the intestine.
Indications for use of the drug
In what cases is Indapamide prescribed to patients? Indications for use of this tool include only one pathological condition of the patient. This is arterial hypertension. In addition, a medication can be prescribed with a delay in sodium and water in the body. As a rule, this condition is very often observed in chronic heart failure.
Contraindications to the use of the drug
Now you know what Indapamide is intended for (the indications for the use of this drug were presented a little higher). However, it should be noted that this medication has contraindications. These include the following factors:
- lactose intolerance by the patient;
- pregnancy period;
- galactosemia;
- hypokalemia;
- malabsorption syndrome of galactose or glucose;
- lactation period;
- the simultaneous use of medications that can extend the QT interval;
- severe renal failure (or stage of anuria);
- a person's age is up to 18 years (the safety and effectiveness of the drug in the treatment of children have not been established);
- severe hepatic, including with encephalopathy, failure;
- hypersensitivity to the drug and other sulfonamide derivatives.
Cautious use of the drug
Many people are interested in: do you need a prescription to buy Indapamide? In fact, before using any medicine, it is recommended to consult a doctor - only a specialist after examination and based on the results of the analyzes will be able to build a competent treatment regimen. As for our case, we note that the drug under consideration is prescribed with special care to people with diabetes, gout, as well as to those patients who are allergic to sulfonamide derivatives.
Among other things, the medicine should be carefully taken for violations of the liver, kidneys and water-electrolyte imbalance.
During therapy, the doctor must constantly monitor the level of electrolytes in the patient’s blood (potassium, sodium, calcium).
The drug "Indapamide": instructions for use, reviews of specialists
According to the attached instructions, this medication must be taken orally, regardless of food intake. The tablet should be washed down with a sufficient amount of clean water.
How to take "Indapamide"? According to experts, this medication is better absorbed from the digestive tract only in the early morning. Therefore, it is recommended to be taken exclusively at this time of day.
The dosage of the drug should be 2.5 mg (i.e. 1 tablet) per day. If, after 4-8 weeks of therapy, the desired effect has not been achieved, then the volume of the medication should not be increased (although often doctors do just that). This fact is due to the fact that with a large dosage, the risk of side effects increases. Instead, another antihypertensive agent that is not a diuretic should be included in drug therapy.
How to take "Indapamide" in this case? With the simultaneous appointment of two drugs, the dose of the drug we are considering remains the same, that is, 2.5 mg per day (early in the morning).
Cases of overdose: symptoms, treatment
What happens if you take a large amount of Indapamide? Reviews of doctors say that in such cases, the patient experiences nausea, weakness, and vomiting. In addition, the patient is disturbed by the water-electrolyte balance and the work of the digestive tract. In some cases, the patient has a strong decrease in blood pressure and depressed breathing. In patients with cirrhosis of the liver, hepatic coma is possible .
How to treat? In case of an overdose, the patient should rinse the stomach, adjust the water-electrolyte balance, and apply symptomatic therapy.
Side effects after taking the medication
Can negative reactions occur after taking Indapamide? This drug has side effects. We list them right now.
- Digestive system: gastralgia, nausea, abdominal pain, vomiting, anorexia, constipation, dry mouth, pancreatitis, diarrhea, hepatic encephalopathy.
- Respiratory system: sinusitis, cough, rhinitis and pharyngitis.
- Nervous system: insomnia, asthenia, muscle spasms, nervousness, general weakness, anxiety, headaches, fatigue, vertigo, dizziness, depression, drowsiness, irritability, malaise and tension.
- Urinary system: nocturia, frequent infections and polyuria.
- Heart and blood vessels: arrhythmia, orthostatic hypotension, palpitations and ECG changes (i.e. hypokalemia).
- Allergy: urticaria, rash, hemorrhagic vasculitis and pruritus.
- Hematopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, bone marrow aplasia and agranulocytosis.
- Laboratory indicators: glucosuria, hyperuricemia, increased urea nitrogen in blood plasma, hyperglycemia, hypercreatininemia, hypokalemia, hypercalcemia, hyponatremia and hypochloremia.
- Others: exacerbation of systemic lupus erythematosus.
Interaction with other medicines
The drug "Indapamide", the action of which is aimed at lowering the pressure, is not recommended to be taken with cardiac glycosides, since the likelihood of digitalis intoxication increases. If you use this tool with calcium preparations and metformin, then the patient may develop hypercalcemia and aggravate lactic acidosis.
The simultaneous administration of a medication with corticosteroids, NSAIDs, sympathomimetics and tetracosactide reduces the hypotensive effect of the former. As for the “Baklofen” product, on the contrary, it intensifies with it.
The combination of the drug with potassium-sparing diuretics is effective in a small number of patients. However, the possibility of developing hyper- or hypokalemia is not excluded, especially in patients with renal failure and diabetes mellitus.
ACE inhibitors can increase the risk of arterial hypotension and acute renal failure.
Renal function may be impaired while using iodine-containing agents in high doses.
Antipsychotics and imipramine antidepressants enhance the hypotensive effect and increase the risk of orthostatic hypotension.
Special instructions for the use of the drug "Indapamide"
In what cases should the patient’s blood picture be monitored after Indapamide is prescribed? Reviews of doctors say that this medication can change the amount of creatinine and potassium ions in those patients who take laxatives, cardiac glycosides, as well as in people over 60 years of age.
When using this tool, specialists are advised to systematically monitor the concentration of sodium, potassium and magnesium ions in the blood plasma, as patients may develop electrolyte disturbances. It is also necessary to monitor the pH, the concentration of uric acid, glucose and residual nitrogen.
Patients with cirrhosis of the liver (with severe edema or ascites), as well as with heart failure and coronary heart disease should undergo special control.
An increased risk group includes patients with an increased QT interval on the ECG (it may be congenital or develop against the background of any pathology).
The first measurement of the concentration of potassium ions in the patient’s blood is recommended in the first week of treatment.
Particular attention is recommended to be given to patients with diabetes. In particular, it is necessary to monitor the level of glucose in the blood, especially if a person is diagnosed with hypokalemia.
Patients taking this medication should compensate for the loss of water by drinking plenty of fluids per day. Moreover, at the very beginning of therapy, they need to control the work of the kidneys.
It is impossible not to say that the drug "Indapamide", analogues of which will be presented later, can give a positive result during the doping control.
Patients with hyponatremia and arterial hypertension 3 days before the start of the use of angiotensin-converting enzyme inhibitors should stop taking diuretics. Treatment can be resumed a little later.
When prescribing Indapamide, specialists should take into account that sulfonamide derivatives can easily cause an exacerbation of a disease such as systemic lupus erythematosus.
To date, the safety and effectiveness of the drug in the treatment of young children and adolescents has not been established.
In some cases, individual reactions are possible that are associated with a change in blood pressure. As a rule, this occurs at the very beginning of therapy, as well as when using another antihypertensive drug. As a result of this, the ability to control the machine and work with other mechanisms may be reduced, which requires increased attention.
Reviews of specialists and patients about the drug
Now you know what Indapamide is. Reviews, the price of this medication will be presented right now.
Experts say that this medicine copes well with the task. It effectively lowers blood pressure and also acts as a diuretic.
Reviews on the drug "Indapamide" indicate that after its use, left ventricular hypertrophy decreases, and its hypotensive effect is manifested even in those patients who are on hemodialysis.
As for the negative statements addressed to the mentioned funds, then most often they are associated with the manifestation of a large number of adverse reactions. However, it should be noted that such effects are observed only in those who have exceeded the prescribed dosage of the drug or have taken it, despite the existing contraindications.
Price and analogues of the drug
How much is the drug "Indapamide"? The price of this medication may be different (depending on the manufacturer and the margin of the pharmacy chain). However, on average, this tool can be purchased for 95-100 Russian rubles (for 30 tablets).
But what if the patient was unable to find the drug Indapamide? Analogs, the price of which is also not very high, are sold in almost every pharmacy. These medicines include the following: Indapamide Retard, Acripamide, Indapamide-Teva, CP-Indamed, Acripamide Retard, Ravel SR, Akuter-Sanovel, Retapres, Arindap ”,“ Lorvas ”,“ Arifon ”,“ Pamid ”,“ Arifon Retard ”,“ Tenzar ”,“ Ipres Long ”,“ Vero-Indapamide ”,“ Indipam ”,“ Indap ”,“ Indiur ”,“ Indapamide-Verte "," Ionik "," Indapamide retard-Teva "," Indapres "," Indapamide Sandoz "," Ionik retard "," Indapamide-OBL "," Indapamide Stada "and so on.
It is strictly forbidden to take these funds at your own discretion and replace the Indapamide medication with them. Only a doctor should prescribe them, and only after a medical examination. Also, before taking these medicines, you must read the attached instructions.
Storage conditions of the drug and its shelf life
It is necessary to store the medicine in a dry and dark place that is inaccessible to small children. The storage temperature of the drug should not exceed 25 degrees. Shelf life is 3 years. After the specified period, taking the medication is strictly prohibited.