In the article, we consider the instructions for use for the Eufillin tablets.
It should be noted right away that such a drug quite effectively eliminates cramps with barking dry cough, but does not directly treat a cough, only temporarily alleviating the patient's condition. This time is necessary until the action of other drugs begins. Thanks to Eufillin, the patient can breathe and does not feel pain. The features of the effect of the drug, its positive effect and possible side symptoms will be described in detail in this article.
Pharmacology
According to the instructions for Eufillin tablets, due to the pharmacological effect of the drug, the bronchial muscles relax, mucociliary clearance increases , the function of reducing the diaphragm is stimulated, and the functionality of not only respiratory, but also intercostal muscles is significantly reduced.
In addition, the effect of the drug stimulates the respiratory center, increasing its sensitivity to carbon dioxide, as well as improving ventilation of the alveoli.
Respiratory function returns to normal under the influence of the drug, increases the oxygen saturation of the blood and thereby reduces the content of carbon dioxide in it.
In addition, the stimulating effect of the drug is on the activity of the heart, increasing heart rate and increasing coronary blood flow and myocardial oxygen demand. The vascular tone of the skin, brain and kidneys is reduced.
In addition, the scope of influence of Eufillin tablets includes:
- the provision of venodilating peripheral action;
- decrease in pressure in a small circle of blood circulation;
- decrease in vascular pulmonary resistance;
- increased blood flow in the kidneys;
- the provision of a diuretic moderate effect;
- inhibition of platelet aggregation;
- expansion of the biliary extrahepatic tract;
- increased resistance to erythrocyte deformation;
- reduction of blood clots and normalization of microcirculation;
- epileptogenic effect with the use of large doses;
- increased acidity of the juice of the stomach due to the tocolytic effect of the drug.
Pharmacokinetics of the drug
When the drug “Eufilin” penetrates the patient’s body, its complete and rapid absorption occurs. The bioavailability indicator in percent is 90-100. The rate of absorption may be affected by food, but not by volume. The highest efficiency from taking the drug is achieved within two hours.
The drug is able to penetrate into breast milk of a woman by about ten percent of the total dose and through the placental barrier, where its concentration is significantly higher compared to the concentration in the mother’s plasma.
For the occurrence of bronchodilating signs of the active component of the drug, its content of 10-20 micrograms per milliliter is sufficient. A higher concentration of it becomes toxic. Interestingly, the lower the blood content of the drug, the better the effect of the excitation of the respiratory center.
The drug is metabolized mainly in the liver, the half-life depends on the general condition of the patient. Excretion of it occurs with the help of the kidneys.
In what cases is this drug used?
The use of Eufillin tablets is justified for the treatment of patients suffering from a number of diseases requiring a bronchodilator effect:
- bronchial obstructive syndrome;
- bronchial asthma;
- pulmonary emphysema;
- chronic pulmonary obstructive disease;
- obstructive chronic bronchitis;
- pulmonary heart syndrome;
- apnea attacks at night;
- hypertension of the lungs.
Rules for taking pills
Eufillin tablets are taken orally. You can drink three times a day at 0.15 grams. The medicine must be taken after meals and washed down with clean water. In childhood, it is allowed to take the drug four times at seven milligrams per kilogram of weight. The treatment course with tablets is determined by a specialist. It can last from a few days to two months.
Contraindications to the use of this drug
Eufillin tablets cannot be prescribed in situations where the patient has excessive sensitivity to the substances of the drug, especially to its active component.
In addition, the medication is contraindicated if the patient has a number of diagnostic indications:
- epilepsy;
- exacerbation of peptic ulcer of the duodenum and stomach;
- gastritis (if acidity is increased);
- arterial hypotension or severe hypertension;
- hemorrhagic type of stroke;
- tachyarrhythmia;
- retinal hemorrhage;
- children's age up to three years.
Caution in the use of Eufillin tablets is required in the following cases:
- with severe coronary insufficiency (in the acute phase of angina pectoris, myocardial infarction);
- with common vascular atherosclerosis;
- with obstructive hypertrophic cardiomyopathy;
- in childhood;
- in advanced years;
- with frequent ventricular extrasystole;
- during pregnancy;
- with excessive convulsive readiness;
- with gastroesophageal reflux;
- with kidney and liver failure;
- with prolonged hyperthermia;
- with peptic ulcer of the duodenum and stomach;
- with uncontrolled thyrotoxicosis and hypothyroidism;
- with bleeding from the digestive tract.
The consequences of drug overdose
If the patient drank an excessive amount of Eufillin tablets, dangerous complications may occur. It is necessary to go to a medical institution in a timely manner and rinse the stomach. The attending physician should immediately report all negative symptoms. Among them are the following:
- loss of appetite;
- the urge to vomit;
- diarrhea;
- gastric bleeding;
- severe pain in the abdomen;
- frequent heartbeat;
- overexcitation of the patient;
- insomnia;
- facial redness;
- the appearance of feelings of fear and anxiety;
- the onset of seizures and the occurrence of epilepsy;
- loss of consciousness by a person;
- lowering blood pressure;
- fear of light and dizziness.
Cough Therapy with Eufillin
Often, specialists cough out prescribing treatment for patients using Eufillin. Thanks to him, the bronchi quickly expand, as well as improves breathing in general. Attacks and pathological wheezing will pass. But treating a small cough with such a strong drug is not recommended. “Eufillin” is prescribed exclusively by the attending physician if there are severe attacks.
If the patient has a painful cough and periodic suffocation, then it is allowed to drink the medicine three times a day. In this case, a six-hour interval between each dose of the drug should be maintained.
The interaction of this drug with other medicines
According to the instructions for use with Eufillin cough tablets, if you take a drug with mineralocorticosteroids, glucocorticosteroids, beta-adrenostimulants, medicines for general anesthesia, Xanthine and drugs that stimulate the central nervous system, the likelihood of side effects may be increased.
The use of antidiarrheal agents and enterosorbents will reduce the absorption of the main component of Eufillin.
Simultaneous therapy with aminoglutethimide, isoniazid, rifampicin, sulfinpyrazone, phenobarbital, carbamazepine, phenytoin, morazizin and estrogen-containing oral contraceptives increases the clearance of the main active component of the drug, and this may cause a need for an increase in dosage.
The combined use of drugs of the macrolide group, allopurinol, verapamil, lincomycin, ticlopidine, cimetidine, thiabendazole, isoprenaline, propafenone, enoxacinoma, mexiletine, disulfiram, methotrexate, fluoroquinolonamine, small amounts of recombinant interferon alfa-influenza can be reduced (recombinant interferon alfa doses of “Eufillin”, since these drugs contribute to increasing the intensity of its influence.
Cough pills "Eufillin" with simultaneous use with diuretics and beta-adrenostimulants increase the effectiveness of these funds. A decrease in efficacy from consumption has been observed when combined with lithium preparations and beta-blockers.
Antispasmodics are perfectly combined, which can not be said about other xanthine derivatives, which are not recommended for use simultaneously with the drug.
This is confirmed by the instruction for cough tablets "Eufillin."
Analogs of “Eufillin”
The remedy during therapy can be replaced with drugs that are similar in their active substance and composition. These include the following:
- “Eufillin Darnitsa”;
- "Aminophylline Eskom";
- solution of "Eufillin" for injection 2.4%;
- Aminophylline.
Reviews about the tablets "Eufillin"
Reviews about the drug "Eufillin" are mostly positive. People who used it are pleased with the speed of exposure and the effectiveness of the drug in eliminating shortness of breath and easing breathing. Many patients use it to eliminate edema, and only an impressive list of side effects in some cases prevents the acquisition of this drug. However, the affordable cost of this medicine and the possibility of using it by different categories of patients is still of great importance in preference to other drugs of this group.
Thus, “Eufillin” is an ambulance, often saving the lives of those people who are suffocating from bronchial spasm. He plays the same role in case of circulatory disturbance of the brain. The only thing that is not allowed during treatment with Eufillin is amateur activity, that is, self-medication. It should be treated only under the supervision of doctors.