The action of "Mifepristone" described in the instruction, its features and the nuances of safe use should be known to doctors specializing in gynecology and obstetrics. A woman who needs an abortion or an indication of the birth of a bearing fetus should also be guided in this information. On sale "Mifepristone" is presented in tablet form. The tool is used strictly in a clinic, unauthorized admission is strictly prohibited.
general information
The mechanism, features, nuances of the action of Mifepristone tablets are described in the documentation accompanying the drug. Many women who used the drug under the supervision of a doctor noted the absence of any changes immediately after taking the medication. Before considering what effect the medicine has on the human body, you should pay attention to the features of the release.
"Mifepristone" is a tablet in each instance containing 200 mg of the active compound. Normally, it has a light yellowish color, a shade of green is possible. The composition and effect of the drug "Mifepristone" are described in the accompanying instructions, which are necessarily present in the package of the product. In addition to the active compound, the manufacturer uses starches and lactose, cellulose and magnesium stearate, as well as polyvinylpyrrolidone in the manufacture of the pharmaceutical product.
Pharmacology
The mechanism of action of Mifepristone is associated with the characteristics of the hormonal background of a person. The drug supplies an orally synthetic steroid substance that interrupts the normal process of gestation. The tool is intended to inhibit receptors that perceive progesterone. The drug does not have a gestagen effect. The antagonistic ability with respect to glucocorticoids was revealed.
The action of "Mifepristone" to stimulate labor and interruption is due to an increase in the ability of the myometrium to contract. This is due to the release of the eighth interleukin in cell structures. Due to this, the susceptibility of uterine tissues to prostaglandins increases. To maximize the effectiveness of the course, Mifepristone is used simultaneously with synthetic prostaglandins. The effect of the drug on the human body leads to desquamation of the membrane, after which the egg is naturally rejected and eliminated from the female body.
Kinetics
After taking Mifepristone, the action begins immediately after absorption of the drug into the circulatory system. A single use of 600 mg of the substance in food allows you to get the highest concentration of the active compound in the blood after 1.3 hours. On average, the parameters vary about 1.98 mg / L. The indicators obtained in the study of blood serum of pregnant women. The bioavailability of the drug is estimated at 69%.
The action of Mifepristone tablets (second, first, third) is due to the ability of the active compound to enter into strong bonds with serum proteins. The probability of a substance entering into communication with the transport system is estimated at 98%. The most active are albumin, an acidic glycoprotein of the first alpha type. Soon after the distribution of the substance throughout the body, elimination begins. At first, the process is quite slow. The concentration indicators are halved in 12-72 hours. Then the process is accelerated. The elimination half-life is estimated at approximately 18 hours.
Is it worth using?
According to reviews, to stimulate the delivery of Mifepristone (the duration of the drug varies, but the first effect is observed at the level of biochemical reactions within an hour and a half after administration) it is used relatively often and gives the desired result. The use of the drug in many patients does not provoke undesirable effects, but there is a risk of side effects. The best impressions of the course remained in women who used the drug under the supervision of a doctor.
If it is necessary to terminate an unwanted pregnancy, Mifepristone is resorted to in the early stages of gestation. Women, forced to practice such a measure, noted that the product did not cause discomfort at first, but by the time the fruit egg was expelled and shortly before that, chills, fever and soreness in the lower abdomen were worried. The drug almost always allows you to achieve the desired effect, although it is possible incomplete interruption, as the manufacturer warns about in the instructions.
When recommended?
The effects of Mifepristone are forced to recognize women who urgently need to interrupt the bearing of the fetus. The tool can be used for up to nine weeks, when no more than 63 days have passed since the last menstrual bleeding. The substance is used only when confirming the location of the fetal egg inside the uterus. In this embodiment, the medication is used in combination with artificially made prostaglandins.
If surgical intervention is necessary to remove the embryo for up to the twelfth week, Mifepristone is used shortly before the intervention in order to conservatively achieve the expansion of the uterine neck.
Indications and Cases
If necessary, termination of pregnancy, the duration of which varies between 13-22 weeks, resort to the action of "Mifepristone" in order to increase the effectiveness of prostaglandins. This is allowed only if there are social, medical recommendations for medical abortion.
If a spontaneous abortion occurred in the second or third part of the term, the fetus died inside the uterine cavity, Mifepriston is used to initiate labor activity.
How to use?
To achieve the maximum effect of Mifepristone, after taking the drug, you need to use several tablets of synthetic prostaglandins. Rules, portions, intervals between doses - the doctor will tell about this at the reception. The first pills will have to be used directly in the clinic. After this, the woman is left for several hours under the supervision of specialists. The manufacturer in the accompanying documentation also indicates the need to use the medicine strictly in an institution with equipment, qualified specialists who can provide urgent help to a woman in need.
It is recommended to use the medication for food an hour and a half after a small meal. Tablets are washed down with half a glass of pure water without additives. To the effect of "Mifepristone" was as pronounced as possible, 0.4 g of "Misoprostol" is prescribed. 36-48 hours after the procedure, an ultrasound examination of the reproductive system is indicated. Re-clinical tests are taken 8-14 days after the event, then another ultrasound is done. The detection of beta-HCG is shown. The main task of the tests is to clarify the fact of a miscarriage. If the pregnancy continues or the termination is not complete, two weeks after taking Mifepristone, the woman is sent for vacuum aspiration. The resulting tissue must be examined in a laboratory.
Sometimes there is a need for the action of "Mifepristone" for childbirth. Time with this course is especially important. The first dose is used in the presence of a doctor (0.2 g), exactly the same day, take the same amount. After 48-72 hours, the condition of the reproductive system is checked in a clinical setting. If this is indicated, a woman is prescribed prostaglandins, oxytocin.
Unwanted effects
During the action of Mifepristone, uterine subinvolution is possible. From clinical practice it is known: in some women in the lower abdomen there are painful sensations, discomfort worries. There is a danger of metrorrhagia, lochiometers. In the presence of an infectious focus in the reproductive or urinary system while taking medication, an exacerbation of the pathological process is possible. Side effects of Mifepristone include a headache, a general weak state.
It is noted that some were sick and vomited. Perhaps a violation of the stool. Some women were dizzy, others chilled. Side effects of Mifepristone may include a fever, fever. The combined use of the drug and synthetic prostaglandins is accompanied by the danger of developing vaginitis, sleep disturbance, soreness of the lower extremities. Some have dyspepsia, asthenia, and concern. There is a risk of anemia, leucorrhea, and a tendency to fainting.
It is impossible!
It is forbidden to test the effect of Mifepristone on yourself if hypersensitivity to any substances present in the medication is detected - this applies to both the main compound and auxiliary. It is forbidden to take the described course against the backdrop of insufficient work of the adrenal glands, liver, kidneys in an acute form or in a chronicle. Mifepristone cannot be used if a woman has been using glucocorticosteroids for a long time. Contraindications are porphyria, uterine fibroids, uterine scar, anemia, and malfunctioning of hemostasis. You can not use the composition if a recent course of blood thinners has been taken.
A contraindication for taking Mifepristone is the inflammatory process in the reproductive system or extragenital pathology, which is very difficult. At the age of over 35 and with addiction to smoking, Mifepristone is strictly contraindicated without preliminary examinations and tests.
Goals and limitations
If necessary, interrupt the bearing of the fetus "Mifepristone" is prohibited to take if there is a suspicion of attachment of the fetal egg outside the uterine cavity. You can not use the tool if clinical studies have not confirmed the fact of conception, while 42 days have passed since the last menstrual bleeding, and before that the woman used hormonal birth control or an intrauterine device.
If necessary, prepare for childbirth "Mifepristone" can be used if severe gestosis, eclampsia and its preceding condition are excluded. You can not use the drug if childbirth is expected earlier or later than the due date.
The extremely accurately described composition is used against the background of COPD, severe asthma. Restrictions are considered high blood pressure, heart failure and interruptions in the frequency, speed, rhythm of the heartbeat.
Mutual influence
To minimize the likelihood of side effects of Mifepristone, it is necessary to exclude, if possible, the ingestion of both this drug and non-hormonal drugs to stop the activity of foci of inflammation. You can not use acetylsalicylic acid if it is needed in progesterone antagonists. Ignoring this condition may cause the ineffectiveness of the drug course.
Nuances and subtleties of use
The use of the agent in question in an amount up to 2 g does not lead to an increase in undesirable actions. An overdose can cause adrenal insufficiency. When this effect is detected, drugs and procedures are prescribed, focusing on the woman's condition, symptoms.
Mifepristone is supplied to medical institutions specializing in gynecology and obstetrics. The product is sold in state organizations, in private and municipal clinics that have the appropriate license. If it is impossible to use the described tool, it makes sense to consider alternative options: “Mifegin”, “Mifiprex”. A good reputation is for the medicines Mifolian and Pencrofton. Both the pills in question and alternative drugs belong to the group of hormones.
Safety Above All
Already at the stage of developing the course, a woman must be warned: it is impossible to maintain a pregnancy, even if Mifepriston does not show the desired effect. If there is no result when taking pills, there is a need for surgical intervention to interrupt the gestation process. Otherwise, the probability of the formation of significant malformations is high. If a woman is breastfeeding, two weeks after using Mifepristone, the child should be transferred to alternative nutrition options.
The use of "Mifepristone" forces to take measures to exclude Rh alloimmunization. Other procedures and measures accompanying abortions of all types and forms are shown. The agent in question can be used only in stationary conditions. In the presence of a synthetic valve in the heart, when detecting endocarditis of an infectious nature, the use of a hormonal drug is accompanied by an antibacterial course in order to prevent infection activity.
Abortion: A Difficult Question
Nowadays, a woman who needs an abortion can go to a specialized medical institution where she will be offered several options and procedures to get rid of the fetus. Usually, the choice is made in favor of a specific one, focusing on the gestational age and health features. If conception has occurred recently, resort to vacuum aspiration, with a period of up to three months, uterine curettage can be done. Salt abortion is a long-term procedure. At the same time, water around the fetus is replaced with a specialized saline solution, which leads to the death of the embryo. Perhaps termination of pregnancy when using an intrauterine device, hormonal contraceptives. This can happen completely imperceptibly for the woman herself, therefore, it is not uncommon for a woman to not even know how many conceptions she actually had in her life.
The classic idea of abortion is a curettage procedure, rather crude and dangerous, with the possibility of serious injury. It can cause infertility for life. The modern alternative is Mifepristone, which does not require surgical intervention.
Features and nuances
The medicine "Mifepristone" contains 200 mg of the active substance, which, when using three tablets, allows you to terminate the pregnancy. When using a substance in a small dosage, a contraceptive effect is observed, the suppression of ovulation. The cycle of menstrual bleeding is lost, the regularity of the cycle is violated. To terminate a pregnancy, you must take a large dose. The placenta becomes immune to progesterone, cannot develop. For this reason, the fetus does not receive oxygen, nutrients, which leads to its death. Prostaglandins, necessary for continuing the course of abortion, stimulate uterine contractions, which allow eliminating the remains from the body. The likelihood of drug failure is extremely low.