"Vinpocetine" is a drug for the correction of cerebrovascular accidents. It affects the blood vessels and metabolic processes in the tissues of the brain, and therefore is used to solve many neurological problems, as well as eliminate the consequences of a stroke.
This drug is intended to improve blood circulation and metabolism in the tissues of the brain. Reviews about "Vinpocetine" below.
Release form
Vinpocetine is available in two main forms - tablets and concentrate for intramuscular injection. Tablets are round biconvex, white or light yellow in color, with serif on one side. Packages are available in 10, 20, 30, 50 or 100 tablets. There is also "Vinpocetine" in ampoules. The concentrate is a clear, slightly colored solution. In one ampoule there can be 2 or 5 ml of a substance that release 5 or 10 ampoules per pack, 1 or 2 packs in a cardboard box. Analogues of the drug "Vinpocetine" should be selected by a doctor.
Structure
The tablet may contain 5 or 10 mg of the active substance. Excipients used in the composition of the tablet are: potato starch, lactose, magnesium stearate, colloidal silicon dioxide.
In 1 ml of concentrated solution for injection contains 5 mg of the active substance vinpocetine. Additional components in the composition of the solution are: citric acid, sodium sulfite, sorbidol, hydrochloric acid, edetate disodium, water, propylene glycol, sodium disulfite. Reviews about "Vinpocetine" say that this medicine has many side effects.
pharmachologic effect
The drug acts on the central nervous system, enhances the supply of blood to the brain, and also has a pronounced anti-aggregation, anti-hypoxic and vasodilator effect. The mechanism of action of the drug is based on the inhibition of phosphodiesterase, which causes an increase in the percentage of cAMP in the cells. Therefore, the calcium content in the cytoplasm of smooth muscle fiber cells decreases and smooth and striated muscles relax. The metabolic processes in the tissues are also normalized and the vessels of the brain expand (mainly in ischemic areas), the flow of oxygen into the brain tissue improves.
In addition, the drug helps to increase the level of catecholamines in the brain and spinal cord, utilizes glucose, and stimulates the metabolism of serotonin in the brain tissues. Reduces platelet aggregation, dilutes blood, enhances red blood cell deformation and normalizes venous outflow by reducing vascular resistance in the brain. Blood pressure decreases slightly. “Vinpocetine” is effective during a stroke: it accelerates the reduction of symptoms, increases attention, memory, and intellectual activity.
Instruction manual
For the treatment of the initial stage, as a rule, tablets with a dosage of 5-10 mg are used, and the administration of tablets varies from 1 to 3 times during the day. The number of receptions depends on the severity of the disease and the doctor's recommendation.
"Vinpocetine Acre" must be drunk after eating, 1 tablet three times a day. The initial dosage per day is 15 mg. The maximum dosage is 30 mg. The duration of treatment and the intensity depends on the conclusion of the doctor, it can reach up to three months. Toward the end of therapy, the dosage of the drug is gradually reduced, until the drug is completely discontinued.
And how to use "Vinpocetine" intramuscularly? In the form of intramuscular injections, the drug is used mainly in acute conditions, one dose is 20 mg. When the body tolerates the drug normally, the dosage is increased after 3-4 days to 1 mg / kg of body weight. The duration of the drug on average is 10-14 days.
In what cases is prescribed?
Indications for use of the drug "Vinpocetine":
- post-traumatic encephalopathy;
- cerebrovascular insufficiency;
- vegetative-vascular dystonia;
- encephalopathy;
- Meniere's disease;
- vascular lesions of the membrane and retina.
Consider also the side effects and contraindications of Vinpocetine.
Contraindications
There are a number of diseases and conditions in which taking the drug in any form is contraindicated. These include:
- pronounced individual sensitivity or intolerance to the active or excipients that are part of the drug;
- extensive cerebral hemorrhage, severe cardiac arrhythmias or coronary heart disease;
- age younger than 18 years;
- pregnancy.
Side effects
According to reviews, "Vinpocetine" can provoke adverse reactions of the body:
- reactions of the circulatory system and blood circulation: instability of blood pressure, hot flashes, increased heart rate, ECG changes, extrasystole.
- reactions of the nervous system: sleep disorders, dizziness, headache;
- digestion reactions: heartburn, dry mouth, nausea;
- other adverse reactions of the body: increased sweating, allergic reactions, weakness.
Overdose
Signs of an overdose are pronounced side effects. Overdose treatment: symptomatic therapy, gastric lavage, taking activated charcoal tablets or other enterosorbents.
Interaction
No interactions were detected with the simultaneous use of Clopamide, Hydrolorothiaide, Digoxin, Glibenclamide, Imipramine, Acenocumarol. When used with Methyldopa, a medicine in rare cases causes a hypotensive effect. With this type of treatment, constant monitoring of blood pressure is necessary. Interaction with many drugs has not been identified, but it can be dangerous, because of this, caution is advised when using other drugs in conjunction with the drug "Vinpocetine". The medicine can provoke internal bleeding while heparin therapy is performed.
"Vinpocetine" during pregnancy
During this period, therapy with "Vinpocetine" is contraindicated. If treatment with the drug during lactation is required, then it is necessary to abandon breastfeeding.
special instructions
Caution should be exercised when taking the drug orally for arrhythmias, angina pectoris, decreased vascular tone and unstable pressure.
In the most acute cases, a parenteral drug is used until the patient's condition improves, and then they switch to taking the tablets. The drug is taken for chronic disorders.
With cerebral hemorrhagic stroke, intravenous administration of the drug is allowed only after the acute manifestations are eliminated. Consider the analogues of the drug "Vinpocetine".
Analogs
These include:
- Pramistar
- Sydnocarb;
- "Glycine VIS";
- "Glycine Ozone";
- "Acefen";
- Vinpotropil;
- Bravinton
- "Piracezin";
- "Karnitsetin";
- Fezam;
- Piracetam
- Aminalon;
- Nooclerin
- Semax
- "Olatropil";
- "Cefabol";
- Cerebrocurin;
- "Cerebrolysate";
- Pramistar
There is no information on the effect of the product on the ability to drive vehicles and perform work related to high-risk mechanisms.
Reviews
About "Vinpocetine" patients and doctors respond ambiguously. This drug is most often used to improve blood supply to the brain, or for accelerated rehabilitation after an acute stroke. It is used for periodic maintenance therapy in people with chronic narrowing of the blood vessels of the brain. Doctors relatively rarely use the drug in their practice. According to many experts, it has a minor therapeutic effect, while causing a large number of adverse reactions.
However, in relatively mild cases of cerebrovascular accident, "Vinpocetine" is prescribed due to its low cost. It is not recommended to use this drug without recommendation and observation, since against the background of use, side effects from the cardiovascular system occur, in particular, a decrease in blood pressure and an increase in heart rate. Also, this drug is contraindicated for use by persons under the age of 18.
Patients talk about the effectiveness of using “Vinpocetine” in getting rid of dizziness and headaches caused by short-term spasms of blood vessels, treatment of vegetative-vascular dystonia, and elimination of the consequences of acute stroke.