According to the instructions, Mezim Forte is a powerful digestive enzyme. Its main active ingredient is pancreatin. The dosage form of the drug is tablets or capsules. In this article, we describe the method of use, the benefits and harms of the medication. Before taking the drug, the patient needs to read the information contained in the instructions for use of Mezim Forte.
What is pancreatitis?
According to statistics, a third of the world's population suffers from a deficiency of digestive enzymes. The lack in the human body of its own pancreatic enzymes is a malfunction in the activity of enzymes and their reproduction, which disrupts the process of digestion of food entering the human body. Enzyme deficiency has several varieties, each of which, in turn, has special symptoms and the cause that led to its appearance. This is the basis for treatment and affects what medications will be involved in the fight against a deficiency of digestive enzymes.
Among the factors of enzyme deficiency are:
- Failure in the integrity of the tissues of the internal organ.
- Lack of vitamins.
- A drop in protein in the patient's blood serum.
- Low hemoglobin.
- Improper diet, addiction to spicy and fatty foods.
- Genetic predisposition.
One reason or another becomes leading, depending on the type of shortage. Common signs include gastrointestinal upset.
Under the deficit is understood the lack of juices, acting with due availability of the guarantor of the proper digestion of food. The disease is characterized by:
- Bloating.
- A disorder in the patient's stool (diarrhea).
- A feeling of heaviness in the abdomen.
- Nausea, vomiting.
- Inadequate digestibility of food.
Enzyme deficiencies lead to palpable digestive problems. To make a correct diagnosis, a number of tests are required, including blood for sugar. It is worth remembering that diabetes is one of the most common complications of digestive enzyme deficiency.
Therapy is based on the rejection of alcoholic beverages and products that negatively affect the state of the pancreas. In particular, the diet is enriched with vitamins. Not the least role is played by drugs designed to accelerate the reproduction of enzymes.
Dosage form
According to the instructions, Mezim Forte tablets are pink in color, round in shape, coated with a membrane that is soluble in the intestine, with biconvex surfaces, chamfers, and brown blotches are possible on a break. The main component of the drug is pancreatin.
Tablets are packed in ten pieces in blister packs (blisters), and then - one or two blisters, along with instructions for use in a cardboard box.
Pharmacodynamics
According to the instructions, Mezim Forte is an enzymatic drug that improves digestion. The active substance of the drug, pancreatin, is a powder of pork pancreas. The tablet simultaneously with exocrine pancreatic enzymes (lipase, protease (trypsin and chymotrypsin), amylase) contains other substances. Pancreatic enzymes contained in the Mezim Fort instructions, facilitate the breakdown of proteins, fats and carbohydrates. This leads to their faster absorption in the small intestine. Trypsin suppresses the stimulated secretion of the pancreas, providing an analgesic effect. The maximum enzymatic activity of the drug is observed 45 minutes after ingestion.
Pharmacokinetics
According to the instructions for use, Mezim forte 10000 are tablets coated with an acid-resistant coating that does not dissolve under the action of hydrochloric acid of the stomach and thus protects the enzymes contained in the preparation from inactivation. Dissolution of the membrane and the release of enzymes occurs when the pH value is close to neutral or slightly alkaline.
Indications
The instructions for use of Mezim Forte prescribe that the medication:
- compensates for the lack of enzymes of the own pancreas, breaking down starch, fats, proteins in the small intestine, contributing to their rapid absorption;
- improves the functional state of the digestive system, normalizing it.
According to the instructions for use, Mezim Forte has the following indications:
- Pancreatic dysfunction (chronic pancreatitis, cystic fibrosis).
- Chronic inflammatory diseases of the stomach, intestines, liver, gall bladder.
- Partial removal or irradiation of the digestive tract, accompanied by a violation of the digestion of food, flatulence, diarrhea.
- Gastrointestinal diseases of a functional nature with intestinal infectious diseases, irritable bowel syndrome.
- The need to improve the digestion of food in patients with normal gastrointestinal function in the case of eating fatty, indigestible plant, unusual food, nutritional errors (large amounts of food), and chewing disorders.
- Preparation for x-ray and ultrasound examination of the abdominal organs.
Contraindications
Contraindications to the use of Mezima Forte, according to the instructions, are the following conditions:
- acute pancreatitis;
- exacerbation of chronic pancreatitis;
- personal sensitivity to pancreatin or other components of the drug;
- children's age up to three years.
Pregnancy and lactation
According to the instructions, Mezim forte 10000 can be used during the period of bearing and feeding the baby only in cases where the intended benefit for the expectant mother exceeds the possible likelihood of negative consequences for the fetus or child. This is because there are no reliable clinical data on the administration of pancreatic enzymes in this important period of life of every woman.
Dosage and route of administration
Dosage, according to the instructions to Mezim Fort, is set personally depending on the severity of the disease and the composition of the food. Unless otherwise indicated, the average single dose for adults is between two and four Mezim Forte 10000 tablets per meal. Doctors recommend taking half or a third of a single dose at the beginning of the meal, and the rest during it. The medication is taken orally without chewing and drinking plenty of fluids. It is possible to increase the dosage of Mezim Forte only under the supervision of a physician, while focusing on a decrease in severe symptoms. The maximum daily dose of 15000-20000 PIECES Ph. Eur. lipase / kg body weight.
For children, the dosage regimen is set by the doctor, depending on the severity of the disease and the composition of the food at the rate of 500-1000 ED Ph. Eur. lipase / kg body weight of the child at each meal.
The duration of treatment can vary from several days (with digestive disorders, errors in the diet) to several months and even years (if necessary, constant replacement therapy).
Side effect
What is said about the negative effects of the drug in the instructions for use? Reviews of Mezim Fort, as well as an annotation to the medication, indicate the possibility of side effects or complications even with prolonged and regular use of the drug in patients with pancreatic dysfunction. Sometimes after taking pancreatin, an allergy is possible, and extremely rarely - diarrhea or constipation, nausea, discomfort in the abdomen.
In rare cases, in patients suffering from a genetic disease, with prolonged use of large doses of the drug, an increase in the level of uric acid in the blood plasma and the formation of strictures in the ileocecal region and the ascending colon are possible.
Overdose
There were no cases of drug overdose. This is confirmed by the instructions to the Mezim Fort. According to doctors, in rare cases, hyperuricosuria, hyperuricemia are possible. However, these conditions are not irreversible.
Instructions for use "Mezima Forte" for children warns parents about the possibility of constipation in young patients. The treatment is discontinuation of the drug and symptomatic therapy.
Interaction with other drugs
Let us briefly describe the possibility of taking Mezim Forte with other medicines:
- When taking drugs containing pancreatin, a decrease in the absorption of folic acid is possible.
- The effect of sugar-lowering drugs may decrease while taking with pancreatin.
- With the simultaneous use of pancreatin with iron preparations, a decrease in the absorption of the latter is possible.
- The simultaneous use of antacids containing calcium carbonate or magnesium hydroxide can lead to a decrease in the effectiveness of the medication.
special instructions
With pancreatitis at the stage of reducing the exacerbation of the disease or during the period of restorative dietary nutrition, it is advisable to prescribe Mezim Forte against the background of decreased pancreatic activity.
The medication, taking into account the solid indivisible capsule form, is contraindicated in children under three years of age.
Mezim Forte does not significantly affect the speed of psychomotor reactions and the patient's ability to perceive or evaluate the situation.
Storage and Vacation
According to the instructions to Mezim Forte, the drug must be placed out of the reach of children and stored for three years. It is not recommended to take the drug after the expiration date. In pharmacies Mezim Forte is dispensed without a prescription.
Analogs
So, we have reviewed the instructions for use with Mezim Fort. Analogues of the drug are of interest to many. We list the main ones:
- Pancreatin This is a medicine that is produced in our country. It is obtained from enzymes of the pancreas of animals. The medication is available in the form of tablets. The enzymes that make up Pancreatin help accelerate the digestion of all substances that enter the human body along with food. The use of "Pancreatin" in the treatment of diseases of the digestive system helps to normalize the activity of the pancreas and restore digestion. The duration of use of the drug must be determined by the attending physician. It depends on the diagnosis and can go up to several months. In patients requiring regular replacement therapy, treatment can last several years.
- Panzinorm forte. This medication reduces the deficiency of digestive enzymes, increases metabolism. The drug increases the assimilation of all types of food, improves the nutrition of the patient, prevents or reduces symptoms caused by the violation of the processes of assimilation of nutrients in the digestive tract. Pancreatin reduces pain in pancreatitis.
- Hermitage. The drug contains pancreatin obtained from pig pancreas. Hermitage makes up for the lack of essential enzymes. They contribute to the breakdown of proteins, fats, starch, improve the functional state of the digestive system, normalize its processes. The release form of the drug ensures the complete release of microtablets from the capsule in the stomach, followed by mixing them with the contents of the small intestine and the rapid release of enzymes from microtablets in the duodenum. Digestion digestion products are absorbed in the intestine either directly or after digestion by intestinal enzymes.
- "Pangrol." The gelatin capsules of the drug quickly dissolve in the stomach, releasing enzymes that remain protected from absorption in the stomach. The form of release of the drug provides their mixing with the contents of the intestine and distribution in the digestive tract. Dissolution of the membrane and activation of enzymes occurs in the small intestine. Pancreatin is not absorbed in the digestive tract, excreted in the patient's feces.
- Mikrazim. Enzyme preparation from animal pancreas. Pancreatin provides the mixing of enzymes with the contents of the intestine and their uniform distribution in it. The enzymatic activity of pancreatin is manifested maximally half an hour after ingestion. "Mikrazim" is not absorbed in the digestive tract and acts locally.
Patients should always carefully study the instructions for the analogues of Mezim Forte.