"Spitomin" is an anxiolytic drug. It is a tranquilizer that also has an antidepressant effect. The difference between this drug and other tranquilizers is that it does not have muscle relaxant, hypnotic, sedative and antiepileptic properties.
The composition and release form of the drug "Spitomin"
The drug has in its composition the active substance buspirone. Spitomin is available in the form of tablets in which the dose of the active ingredient can be either 5 mg or 10 mg. Of the auxiliary substances in the composition of the drug are anhydrous colloidal silicon dioxide, magnesium stearate. Additional ingredients - carboxymethyl starch, microcrystalline cellulose and a substance such as lactose monohydrate have an auxiliary effect.
pharmachologic effect
The drug "Spitomin" reviews of doctors can be attributed to medicines of the non-benzodiazepine series, its effect is defined as antidepressant. The medicine has some differences from the classic versions of anxiolytics. The effect that the drug has is associated with the effect on the human body of buspirone. It affects the activity of the dopaminergic and serotonergic systems. Buspirone, acting on dopamine presynaptic receptors, blocks them, contributes to an increase in the rate of activation of dopamine neurons located in the midbrain.
The active component does not adversely affect the implementation of psychomotor functions, it does not lead to the development of tolerance. The use of "Spitomin" eliminates the appearance of withdrawal syndrome and dependence on this drug. The use of the drug "Spitomin" instructions for use, reviews are not associated with a negative reflection on the action that ethanol has on the body. To obtain the necessary therapeutic effect, it is necessary to be treated for 1-2 weeks, the maximum possible effect can be seen only a month after the start of therapy.
Indications for use of the drug "Spitomin"
The drug is prescribed in such cases:
- panic disorder ;
- withdrawal alcohol syndrome (used as part of complex treatment);
- a syndrome in which vegetative function is impaired;
- generalized anxiety disorder;
- depressive disorders (used as part of combination therapy as an adjuvant).
Contraindications to the reception of "Spitomin"
"Spitomin" instruction, reviews are not recommended for use with:
- hypersensitivity to components;
- myasthenia gravis;
- glaucoma
- breastfeeding;
- pregnancy and suspected presence;
- severe liver and kidney failure;
- childhood (less than 18 years);
- taking MAO inhibitors, the fourteen-day period after the cancellation of the irreversible MAO inhibitor was made, and one day after the rejection of the MAO inhibitor.
In some cases, the drug should be used with caution:
- kidney failure;
- cirrhosis.
Regarding the intake of Spitomin during the period of bearing a child, patient reviews show that this possibility exists. However, continuous medical supervision should be done. The possible benefits for the woman's body should exceed the risk that exists for the fetus.
The use of the drug, dosage
Pills are drunk at the same time. It is possible to take the drug both before and after eating, you should choose one option and always stick to it.
The drug is not suitable for episodic use in case of anxiety, because the therapeutic effect is not immediately detected, but after a while. Repeated use of "Spitomin" is required.
The necessary dose is set for each patient separately. “Spitomin” customer reviews are presented as a drug, the dose of which at the initial stage of treatment in most cases does not exceed 15 mg of the drug per day. An increase in dose is possible every 2-3 days. Moreover, its increase should be gradual, no more than 5 mg at a time. Daily use of the drug is recommended in 2-3 doses. Basically, the dosage of the drug per day is 20-30 mg. The maximum dose available for use at a time corresponds to 30 mg, the maximum possible daily intake is 60 mg.
Disorders in the work of the kidneys require the implementation of therapy based on a reduced dose. For liver problems, special care is needed during the period of treatment with Spitomin, the dosage should also be reduced. For this purpose, the doctor usually reduces some doses, while increasing the intervals between taking the drug.
Side effects of Spitomin
"Spitomin" review does not always receive a positive, and this is due to its ability to cause some unwanted reactions of the body. Typically, the drug is well tolerated by the patient, but sometimes side effects can be detected. If they develop, then this mainly happens at the very beginning of therapy, side effects disappear on their own. Reducing the prescribed dosage is rarely required.
A person may find himself having trouble sleeping, a significant increase in nervous excitability, and a headache. In very rare cases, extrapyramidal disorder may occur . Changes in the digestive system are possible, these are various dyspeptic phenomena, for example, nausea with vomiting, poor appetite.
In case of an overdose with the Spitomin preparation, the feedback of many experts confirms the need to perform gastric lavage and provide therapy aimed at eliminating this condition. There is no antidote; there is no effect from the use of dialysis.
special instructions
Liver failure
The metabolism of the active substance occurs in the liver, with the introduction of 20 mg of the drug at a time to a patient with cirrhosis, the concentration of buspirone in the blood increases, the drug is excreted longer. Since the substance can enter the bile unchanged, a repeated peak in the level of the active ingredient in the blood is possible.
Kidney failure
Regarding treatment with Spitomin, a review by doctors shows that if the failure is moderate or severe, the clearance of the active component may be half as low. Severe insufficiency in which GFR does not exceed 10 ml / min., Its moderate form with an indicator in the region of 10-30 ml / min and mild when the indicator is more than 30 ml / min., Are those conditions in which treatment with Spitomin is possible. "But in a reduced dose and with extreme caution.
Lactose intolerance
Since the tablets contain lactose, this factor should be taken into account when prescribing Spitomin to patients.
Effect on reaction speed and attention
Usually the drug does not have such an effect, but its presence should be determined individually.
Transition with benzodiazepines
The use of the drug is possible only after the withdrawal of benzodiazepines by gradually reducing the dosage.
Drug Dependence
After treatment with Spitomin, the patient review confirms the lack of addiction to the medication. But if the patient has a predisposition to drug dependence, he needs careful monitoring by a specialist.
Recommendations to patients
Do not drink alcohol and grapefruits. It is forbidden to drink juice from grapefruit in large quantities. These products increase the concentration of the active substance in the blood. In addition, they increase the likelihood of side effects and the severity of their course, the frequency of manifestation.
Drug Interaction "Spitomina"
The drug cannot be combined with MAO inhibitors. Its use during the administration of antidepressants, oral contraceptives, antipsychotic drugs should be done with caution. The same applies to cardiac glycosides and hypoglycemic, hypotensive drugs.
The cost of the drug "Spitomin"
When treating with Spitomin, instructions for use, price, reviews are important information for patients. A drug with a dose of the active substance 5 mg (60 pcs.) Can be purchased for about 725 rubles, tablets with 10 mg of the active ingredient (60 pcs.) - for 750-1200 rubles.
Reviews, analogues of the drug "Spitomin"
The drug "Spitomin" price, reviews make it a profitable and effective tool in the treatment of conditions specified in the indications of instructions. The opinion of patients about the drug contains some unpleasant moments. For example, a medicine in combination with Fenlepsin can lead to a deterioration in well-being, which can manifest itself in a swooning state, dizziness, however, such side effects disappear with time. When treating anxiety conditions with Spitomin, headaches and nausea may occur, but later they also pass, and the result of therapy becomes noticeable. Unwanted reactions to Spitomin are rare.
Doctors confirm the effectiveness of the drug when used in order to combat some pathological conditions of the body. In their opinion, with proper use of Spitomin, recovery always ensues.
The only analogue of the drug is Buspirone Sandoz, this option is cheaper. The specialist can choose a substitute for the drug without the presence of buspirone in the composition, usually these are tranquilizers that make up the benzodiazepine series. Such tasks are performed on an individual basis, taking into account the disease and its severity, general health.