The drug âEufillinâ is an antispasmodic drug that has a relaxing effect on the smooth muscles of internal organs, bronchi, blood vessels, bile ducts, etc. The pharmacological group âEufillinâ is xanthines.
Due to its action, the drug relieves spasms and muscle contractions of the internal organs, which can be caused by any external or internal factor.
Thus, the medication promotes the expansion of blood vessels, relieves bronchospasm, reduces the contractility of the uterus, stopping the threat of premature birth, etc.
Instructions for use with Eufillin are presented in this article.
The composition of the drug and the form of release
To date, the drug is produced by various pharmaceutical enterprises in three dosage forms - in the form of tablets and solutions for intravenous and intramuscular administration. The aminophylline substance is used as the main active substance in all forms of Eufillin release. As auxiliary components, the solutions include purified water and a special preservative, which may be different for medicines produced by different factories. Therefore, complete and accurate information about the auxiliary components in the composition of "Eufillina" is contained in the instructions attached to the medicine.
Therapeutic effect
The therapeutic properties of the drug reduce the contractile activity of the smooth muscles of the internal organs, which need to carry out muscle contractions in order to promote their internal contents, for example, the bronchi, uterus, bile ducts, blood vessels, bladder, intestines, etc.
To perform their functions, these organs make spastic movements, which are provided by smooth muscles. In cases where such muscles are excessively tensed, instead of normal rhythmic contractions, a spasm occurs, as a result of which the lumen of a certain organ narrows sharply, as a result of which various substances cease to be transported, or the speed of such a process begins to slow down significantly. For example, a small amount of blood can flow through the narrow lumen of a blood vessel, and air also passes through the narrowed bronchi with difficulty, etc.
In order to normalize the patency of the organ and provide the necessary transportation of substances with the required speed and the right amount, the spasm of smooth muscles should be eliminated, that is, it should be relaxed. After this, the lumen of the organ expands, and the substances must move along it, freely performing their functions.
The mechanism of action of âEufillinâ is based on this.
A medication promotes just such relaxation of smooth muscles and, accordingly, relief of their spasm with the restoration of necessary patency. Since smooth muscles are found in almost all internal organs, when using the drug, smooth muscle structures relax on the part of all body systems. This confirms the instructions for use for Eufillin.
A drug has the following therapeutic effect:
- It relaxes the muscles of the bronchi, expands their lumens, thereby stopping bronchospasm.
- Stimulates the activity of the respiratory center of the brain.
- Reduces the frequency and severity of apnea attacks.
- Enhances heart rate and intensity.
- Increases the speed of cardiac blood flow, normalizes the oxygen demand of the heart muscle.
- It removes the tone in the blood vessels, relaxing their walls and lowering blood pressure.
- Normalizes peripheral microcirculation in various organs and tissues.
- Enhances blood flow to the kidneys, which contributes to a moderate diuretic effect.
- Expands the lumen of the biliary tract, relieving the cramps and pain that accompany this process.
- Prevents the occurrence of allergic reactions.
- Reduces platelet adhesion and prevents blood clots.
- Increases the resistance of blood cells to deformation.
- Promotes tocolytic effect (relaxes the muscles of the uterus and eliminates the threat of premature birth and miscarriage).
- Increases the acidity of the stomach.
- In high doses, this medication can provoke attacks of epilepsy.
Many are interested in what âEufillinâ helps from.
The spectrum of therapeutic properties of the drug, as you can see, is very wide, however, most often this drug is used to eliminate bronchospasm and spastic pain with the development of cholecystitis and some other diseases of the biliary tract, as well as to increase microcirculation. And yet, the main area of ââuse of this medication is the relief of bronchospasm.
Indications for use
According to the instructions for use, "Eufillin" should be used for the following diseases:
- Bronchial asthma.
- Obstructive syndrome in the bronchi of any origin - with asthma, hypertension, COPD, apnea, etc.
- Apnea in newborns.
- In cases of cerebrovascular accident of the ischemic type (as a rule, as one of the components of complex therapy).
- Left ventricular failure, which is accompanied by bronchospasm and Cheyne-Stokes breathing.
- Renal edema (also as part of complex therapy).
Thus, tablets and injections of âEufillinâ are recommended for use in chronic forms of various diseases with periodic episodes of bronchospasm. Intravenous and intramuscular injections with this drug are indicated exclusively for acute and emergency conditions that threaten life, regardless of what reason provoked such conditions.
Contraindications "Eufillina"
The use of the drug is contraindicated if there are: intolerance, myocardial infarction, collapse, paroxysmal tachycardia, extrasystole, epilepsy, hyperthyroidism, peptic ulcer, impaired kidney and liver, prostate adenoma, diarrhea. Do not use the drug in tablets for children under 6 years of age.
Contraindications "Eufillina" should be strictly observed.
Alternative methods of using the drug
The drug is used in the treatment of various pathological disorders and diseases, which include the need to improve blood microcirculation and reduce tension and tissue tone. In such situations, it is recommended to introduce it into the affected area by electrophoresis, which guarantees the immediate penetration of the drug into the tissue.
What else does the instructions for use tell us for Eufillin?
Electrophoresis
Electrophoresis using this medication is advisable when:
- Osteochondrosis.
- Arthrosis and arthritis of various joints.
- Chronic bronchitis.
- Vegetative-vascular dystonia.
- Certain cerebrovascular accidents.
- Increased intracranial pressure.
- Hypertonicity or muscle hypotension in children.
- Dysplasia of the femoral head in children.
- Prolonged shorting of the fontanel in infants.
- A variety of nerve lesions (for example, facial).
Most often, electrophoresis with a medication is prescribed for the development of osteochondrosis in adults, as well as for muscle hypertension in children.
How to use "Eufillin" from the pharmacological group of xanthines?
Mode of application
The tablets of the drug must be taken after meals, whole, washed down with a small volume of water (about half a glass). If necessary (for example, difficulty swallowing), the tablet can be divided into two or four parts and swallow them alternately.
Adults with the treatment of bronchospasm of various etiologies need to use this medication in a dosage of 150 mg 3 times a day. For children, the dosage of Eufillin tablets is calculated individually when taking into account body weight - 7-10 mg per 1 kg. The total amount of medication is divided into 4 doses. The maximum single dose of a medical product for adults should not exceed 500 mg, the daily dose is 1500 mg. For children, this dosage is 10 mg per 1 kg - single, and daily - 15 mg per 1 kg. This is confirmed by the instructions for "Eufillin" for children.
The duration of the course of drug therapy is determined in accordance with individual characteristics and the rate of normalization of the pathological condition.
Thus, for some patients to eliminate bronchospasm it is enough to use this drug for several days, while others will have to drink it for several months. The dosage and duration of treatment is determined by the attending specialist, who is familiar with the medical history of a particular patient, is aware of his reaction to certain medications, etc. If you use this drug on your own, stop treatment no earlier than 5 days after complete relaxation of the bronchi.
In addition to the above scheme for the use of Eufillin tablets for self-treatment, there is also an option for maintenance therapy, which consists in the course of taking this medication after eliminating the acute condition by intravenous injection.
Supportive drug therapy âEufillinâ is aimed at maintaining the result achieved by injection, as well as at achieving stable remission and preventing new episodes of life-threatening bronchospasm. Such therapy should begin with the lowest possible dosage of the drug in the form of tablets, which should be increased by 30% for three days, until the maximum allowable dosage of the drug is reached. The duration of such treatment is determined by the time of onset of stable remission in the absence of episodes of bronchospasm.
Thus, for adults, the maintenance dosage is 1 tablet every 6 hours. After three days, the dosage is increased by 1 tablet. So, the dosage is gradually brought to the maximum.
Lower doses, compared with the main therapeutic, are used in the treatment of chronic forms of obstructive pulmonary diseases. Treatment is started in the acute period with minimal doses and the drug is administered either intramuscularly or orally, in the form of tablets, once, after which they switch to the use of the drug in a maintenance dosage, which depends on the age and condition of the patient.
Are there any side effects of Eufillin?
Adverse reactions
Such negative reactions include: insomnia, dizziness, headache, agitation, tremor, arrhythmia, tachycardia, heart pain, hypotension, abdominal pain, nausea, heartburn, vomiting, diarrhea, allergic reaction, increased sweating, drop in blood glucose changes in urine tests.
Side effects of Eufillin are described in detail in the instructions.
Overdose symptoms
An overdose of this medication may manifest the following symptoms:
- Pain in the stomach.
- Decreased appetite.
- Nausea.
- Diarrhea.
- Vomiting
- Gastrointestinal bleeding.
- Redness of some parts of the body.
- Tachycardia (palpitations).
- Heart rhythm disturbance.
- Insomnia.
- Psychomotor agitation.
- Symptoms of Anxiety
- Photophobia.
- Tremor of hands.
- Cramps.
- Epileptic seizures.
- Blood pressure drops.
- Muscle necrosis.
- Renal failure.
- Confusion.
Treatment of such phenomena of an overdose of âEufillinâ begins, as a rule, with gastric lavage and sorbent intake in combination with laxatives (âBisacodylâ, âSenadeâ), as well as with diuretics (âFurosemideâ).
After this, the intestines are washed with polyethylene glycol (Fortrans) in combination with heavy drinking. With the development of severe conditions, hemosorption, plasma sorption and hemodialysis are carried out, aimed at maintaining the basic functions of the vital systems of the body.
Interaction with other drugs
The solution of "Eufillina" for intravenous administration should not be mixed with acid solutions. The drug increases the risk of side effects from the use of glucocorticosteroids (Prednisolone, Betamethasone, Dexamethasone), drugs for anesthesia and drugs that stimulate the nervous system. Antidiarrheal medicines and sorbents reduce the effect of the drug âEufillinâ, such medicines as âRifampicinâ, âPhenytoinâ, âPhenobarbitalâ, âCarbamazepineâ, âIsoniazidâ, âAminoglutetimideâ, âSulfinpyrazone, oral. The severity of the therapeutic effect of the drug âEufillinâ is enhanced by antibacterial agents from the macrolide group, for example, âLincomycinâ, âAllopurinolâ, âCimetidineâ, âIsoprenalineâ, âEnoxacinâ, âDisulfiramâ, âMethotrexateâ, âMexiletinâ, âPropafenon "," Tiabendazole "," Ticlopidine "," Verapamil ", as well as alcoholic beverages and interferon alpha.
Against the background of the use of the drug âEufillinâ, strong tea and coffee should not be used, because this can cause an overdose of the drug.
Use during pregnancy
The substance of the drug is able to penetrate the placenta and have various negative effects on the fetus, and can also provoke intoxication, which is manifested by vomiting, intense heartbeat, arrhythmia and other symptoms. Nevertheless, if there are certain indications, the use of a medication during pregnancy is possible. What helps âEufillinâ, now we know.
Analogs
Consider the two most popular counterparts:
"Eufillin UBF" is a medicine with bronchodilating action. The composition of aminophylline in a dosage of 150 mg. As a result of the drugâs action, the bronchial muscles relax, the respiratory center is stimulated, the alveoli ventilation improves, the incidence of apnea is reduced, and the pressure of the pulmonary circulation decreases. Tablets are used for obstruction of the bronchi with different origins: bronchial asthma, chronic obstructive pulmonary disease, pulmonary heart, night attacks of apnea. Inside take from 100 mg to four times a day. The frequency of administration, the dosage is adjusted only by the doctor. The presence of epilepsy, ulcerative lesions of the digestive tract, severe cardiac arrhythmias with heart palpitations, hemorrhagic stroke, all this are strict contraindications to the appointment. During therapy, arrhythmias, pain in the heart, stomach, agitation, anxiety are possible. For children use from 3 years old, for pregnant women - for health reasons.
"Teotard" is another drug for bronchodilation. The capsules contain theophylline molecules of 200 and 350 mg. The vessels expand, mucociliary clearance increases , and the respiratory and intercostal muscles are stimulated. It is prescribed for high blood pressure in the pulmonary circulation, night breathing disorders, bronchial obstruction syndrome of any origin. At the beginning of therapy, take 1 tablet every 12 hours. Contraindications - manifestations of epilepsy, retinal hemorrhage, hyperacid gastritis, severe heart rhythm disturbances, gastrointestinal bleeding, and individual intolerance. In the course of therapy, gastroesophageal reflux can manifest itself, an ulcer, insomnia may aggravate, the number of angina attacks may increase, the body temperature may increase, and skin itching may occur. Can be taken for children from 6 years.