Nootropic medicines are medicines that stimulate metabolism in nerve cells and improve the thinking process. These drugs include "Neupilept". A medication is produced in the form of a solution for intravenous or intramuscular use. You will learn about the features of treatment with this drug later in the article.
Composition of "Napilept"
The composition of the drug for parenteral administration includes the following substances:
- citicoline sodium;
- caustic soda;
- water for injections;
- hydrochloric acid solution.
Composition of 1 ml of oral solution:
- citicoline sodium;
- para-hydroxybenzoic acid methyl ester;
- sodium citric acid;
- potassium salt of sorbic acid;
- para-hydroxybenzoic acid propyl ester;
- lemon acid;
- glycine;
- glucite;
- saccharin sodium;
- water;
- strawberry flavoring.
According to the instructions and reviews for the "Napilept", tablets do not exist. The medication is made only in the form of a solution.
Pharmacological actions
The drug has an extensive spectrum of effects. Influencing the mechanisms of apoptosis, the drug prevents cell death, and preventing the increased formation of free radicals, helps to regenerate damaged cell membranes.
In case of traumatic brain injury, “Neupilept” helps to reduce the length of the recovery period, reducing the severity of neurological signs and the duration of post-traumatic coma. In acute stroke, the drug reduces the amount of damage to brain tissue.
The drug reduces the manifestation of memory loss. Neupilept improves attention and consciousness. The medication has increased effectiveness in sensitive and motor neurological lesions of vascular and degenerative etiology.
Conditions in which a medicine is prescribed
Neupilept is recommended for use in the following cases:
- Memory impairment.
- Impairment of mental performance.
- Decrease in cognitive functions (mental processes, thanks to which a person gets the opportunity to perceive, transmit, analyze and memorize various information).
- Violation of the bones of the skull or soft tissues.
- Acute and recovery period.
- An acute period of ischemic stroke (failure of microcirculation of the brain with damage to brain tissue, impaired function due to difficulty or stopping the flow of blood to a particular department).
- Hemorrhagic stroke (acute lesion of cerebral circulation with cerebral hemorrhage).
Contraindications
The medication is forbidden to use in the following conditions:
- Severe vagotonia (a form of vegetovascular dystonia, in which the parasympathetic division of the autonomic nervous system becomes more active and suppresses the functions of the sympathetic division).
- Under the age of eighteen.
- Breastfeeding.
- Increased Sensitivity.
Abstract to the medicine
Solution for injections "Neupilept" is used intramuscularly, as well as intravenously. Jet (for five minutes) or drip (at a speed of forty to sixty drops per minute).
From the reviews and instructions to "Napeilept" it is known that intravenous administration is most preferable. It is necessary to alternate places of parenteral administration. Neupilept should be used immediately after opening the package. The drug is compatible with all solutions.
The oral solution is taken orally with food, dissolved in a small amount of water. The specific dosage and duration of therapy in each situation are determined individually, depending on the disease and the severity of the severity of the signs of the disease.
General recommendations:
- In the acute period of traumatic brain injury and ischemic stroke, 1000 milligrams is prescribed every twelve hours for at least 6 weeks.
- For behavioral and cognitive impairment with vascular and degenerative brain lesions, the recovery period after hemorrhagic and ischemic strokes, it is recommended to use from 500–2000 mg per day.
Negative reactions
In most situations, the drug is well tolerated by patients. According to reviews and instructions for use with Neupilept, in rare cases, the following side effects may occur:
- Loss of appetite.
- Diarrhea (a pathology in which a person has frequent bowel movements, and the stool becomes watery).
- Nausea.
- Vomiting.
- Feeling of heat.
- Insomnia (sleep disturbance, expressed by superficial, intermittent sleep, a delay in its onset or premature awakening).
- Migraine (a neurological disease characterized by periodic or regular bouts of headache on one side).
- Hallucinations (an image that occurs in the mind without an external stimulus).
- Dizziness.
- Excitation.
- Tremor (involuntary, fast, rhythmic oscillatory movements of parts of the body or the whole body, caused by muscle contractions and associated with a temporary delay in correcting afferent signals, due to which the movement is realized and the pose is maintained due to the constant adjustment of the body position to some average value) .
- Shortness of breath (respiratory failure, which is accompanied by a change in its frequency and depth).
- Swelling.
- Rashes.
- Itching of the skin.
- Anaphylactic shock (an acute and extremely severe allergic reaction that develops as a result of repeated exposure to the body of an allergen).
- Orthostatic hypotension (a syndrome that is characterized by a violation of the body's ability to maintain a normal level of blood pressure in an upright position).
- Increased blood pressure.
- Tachycardia (a sharp increase in heart rate, a sign of serious disorders).
- Thrombocytopenia (a pathological condition characterized by a decrease in the number of platelets circulating in the peripheral blood).
- Amenorrhea (absence of menstruation for 6 months in a woman who previously had a normal menstrual cycle; lack of menstruation in girls under 16 years of age).
- Dysmenorrhea (a cyclic pathological process in which severe pain in the lower abdomen appears on the days of menstruation. These pains can be accompanied by other symptoms: general weakness, nausea, vomiting, headache).
- Decreased libido (sexual dysfunction, characterized by mild sexual desire).
- Hypervolemia (violation of the circulating volume of blood through the blood vessels in the direction of increase).
- Hyperglycemia (a clinical symptom indicating an increase in serum glucose compared to normal).
What other negative manifestations can the drug cause?
According to the reviews and instructions for use for injections of "Napilept", as well as a solution for oral administration, the medication can provoke the appearance of certain side effects:
- Priapism (prolonged painful erection that is not associated with sexual arousal and does not stop after sexual intercourse).
- Polyuria (increased urine output per day).
- Urinary incontinence.
- Anorgasmia (lack of orgasm with sufficient sexual stimulation).
- Rhinitis (inflammation of the mucous membrane of the nasal cavity, which is characterized by its edema, congestion, secretion of mucous or serous secretions, poor health and impaired sense of smell).
- Galactorrhea (a pathological process in which a milky liquid is released from the chest).
- Gynecomastia (breast enlargement with hypertrophy of glands and adipose tissue).
- Thrombopenia (a decrease in platelets in the circulating blood).
- Thrombocytopenic purpura (a disease that is characterized by a decreased level of platelets in the blood).
- Rigidity (inability to easily change their positions, opinions, actions appropriate to the situation).
- Hypokinesia (a condition of insufficient motor activity of the body with a limited pace and range of motion).
- Hypersalivation (increased salivation as a result of increased activity of the salivary glands).
- Akathisia (a syndrome characterized by an unpleasant feeling of internal motor anxiety, as well as an internal need to move or change posture, is manifested in the patient's inability to sit quietly in one position for a long time or remain motionless for a long time).
In rare situations, during treatment with Neupilept, an activation of the parasympathetic system is noted, as well as a short-term change in blood pressure.
Features
When treating people with persistent intracranial hemorrhage, people should not exceed a dosage of 1000 mg per day. The drug is recommended to be administered drip, intravenously, at a rate of 30 drops per minute.
Crystals may form in the oral solution in the cold, due to the temporary partial crystallization of the preservative. Subsequently, when stored properly, they dissolve after a few months. These phenomena do not affect the effectiveness of the medication.
It is known from the instructions and reviews for Napilept that during treatment, patients should be especially careful when driving, as well as performing work that requires increased attention.
Pregnancy and lactation
There is no information on the safety of using the drug during an “interesting situation”, therefore, “Napilept” can be prescribed only in situations where the likely benefits of therapy are higher than risks.
Women during lactation, if necessary, need treatment to decide with the doctor the question of stopping breastfeeding, since there is no information about the allocation of the active substance of the drug with breast milk.
Use in childhood and old age
There is no clinical information on the effectiveness and safety of using the medication in pediatrics, therefore, Napilept is not recommended for the treatment of children and adolescents under eighteen years of age. Patients of retirement age dosage adjustment is not required.
Does Neupilept come into contact with other drugs
According to the instructions, the drug can not be used in conjunction with drugs, the structure of which includes meclofenoxate. "Neupilept" with simultaneous use with levodopa enhances the effect of the latter.
Generics
According to reviews, the following are considered analogues of Napilept (injections and solution):
- Quinel.
- Neuroxon.
- Neurocholine.
- Rekognan.
- Proneiro.
- "Citimax".
- "Piracetam".
- Beefrain.
- Phenibut
- Ceraxon.
- "Axobrex".
- Aminalon.
- Vasavital.
- Ceresil Canon.
Shelf life of Napilept is twenty-four months. Keep the drug at a temperature of up to twenty-five degrees of heat in a place inaccessible to children. A medication is prescribed according to the prescription of a specialist. The cost of the drug varies from 350 to 1000 rubles.
Solution for internal use and injections of "Napilept": reviews of doctors and patients
Responses about the drug are usually positive. The medication is well tolerated, has almost no restrictions. In addition, Neupilept improves the condition, including after a stroke or traumatic brain injury.
According to the responses, the drug is successfully used to provide a direct stimulating effect on learning, mental activity.
Patients in the reviews of "Neupilept" talk about the increased effectiveness of the drug with memory impairment, as well as mental performance. The drug is recommended for use by most doctors, it perfectly helps with cerebrovascular accident.
The opinions of medical specialists about the drug, as well as the responses that people leave on the forums, confirm that Napilept is effective both in the acute period and during recovery from a stroke.