Are you familiar with Thiotriazolin? Instructions for use of this medication will be described in detail in the submitted article. In addition, we will tell you about the form in which the medicine mentioned goes on sale, what indications it has, side effects and contraindications.
Composition, packaging of the drug and form of release
In what form is the medicine “Thiotriazolin” released? The instruction informs that it has several different forms. The most popular are the following:
- A solution intended for intramuscular and intravenous injection. 1 ml of such a product contains 0.025 g of thiotriazolin. The medication also has auxiliary components in the form of water for injection. The drug can be purchased in ampoules of 4 ml (placed in a cardboard box).
- Eye drops "Thiotriazolinum". Instructions for the use of such a tool say that 5 ml of the drug contains 50 mg of thiotriazolin, as well as other substances. The drug goes on sale in polyethylene dropper bottles placed in a cardboard box.
- Tablets "Thiotriazolinum". The instructions for this form of the drug say that in one white round tablet with a flat surface contains 100 mg of morpholinium methyl triazolylthioacetate, or the so-called thiotriazoline. Additional components of this medication are potato starch, microcrystalline cellulose, low molecular weight povidone, calcium stearate and sucrose. Typically, there are 50 tablets in a carton.
Pharmacodynamics
What is a remedy like Thiotriazolin? Instructions for use states that it is an antioxidant drug. Its high effectiveness is due to antioxidant, anti-ischemic, immunomodulatory and membrane-stabilizing properties.
The medication in question prevents the death of hepatocytes, helps to restore them, reduces the degree of fatty infiltration, leads to the normalization of protein, carbohydrate, lipid and pigment exchanges, and also reduces the likelihood of the spread of centrolobular necrosis of an organ such as the liver. In addition, this drug improves the excretion and synthesis of bile, normalizes its composition (chemical).
Drug properties
What other properties does the drug “Thiotriazolin” have? Instructions for use of this medication are required to read. After all, only from it you can learn that the medication in question reduces the inhibition of oxidative processes in the Krebs cycle, preserving the intracellular fund of ATP, and also enhances the activation (compensatory) of anaerobic glycolysis.
It should also be noted that after taking the medicine, the active substance begins to activate the antioxidant system, inhibit the oxidative processes of fats in ischemic areas of the body. In addition, this drug improves the properties of (rheological) blood due to the activation of the fibrinolytic system.
The antioxidant properties of the drug are manifested due to the fact that in the structure of the thiotrazoline molecule there are sulfur ions, which are characterized by oxidative and reducing features, as well as tertiary nitrogen, which binds an excess of hydrogen ions.
It should be noted that the active component of the drug is able to react with lipid radicals and reactive oxygen species. This is due to the pronounced reducing properties of the thiol group. In addition, the medication prevents the formation of reactive oxygen species by reactivating antiradical enzymes such as catalase, glutathione peroxidase and superoxide dismutase.
Pharmacokinetics
Is the medication “Thiotriazolin” absorbed? The instruction states that the half-absorption period of the drug is 30 minutes, and the bioavailability is 65.5%.
The maximum concentration of the drug in the blood is achieved 1.4 hours after administration. Communication with proteins does not exceed 10%.
In large quantities, the drug accumulates in the tissues of the liver, heart, rectum, spleen and kidneys, and minor ones in the small intestine and lungs. Thiotriazolin is excreted mainly by the kidneys.
Indications
In the presence of what abnormalities can Thiotriazolinum tablets, injections and eye drops be prescribed? Instructions for the use of these forms contain the following indications:
- cirrhosis of the liver;
- liver damage toxic, alcoholic, viral and medicinal (for example, after taking antibiotics, antiviral drugs, antituberculosis and antitumor agents, oral contraceptives and tricyclic antidepressants);
- chronic viral hepatitis;
- chronic hepatitis of moderate and minimal activity;
- fatty liver dystrophy.
Indications for the use of drops:
- corneal disease;
- burns or injuries to the eyes;
- viral conjunctivitis.
Why else use the ophthalmic drug "Thiotriazolin"? The instruction (drops can be purchased at any pharmacy) informs that this medication is very often prescribed for the prevention of dry eyes, asthenopia and other inflammatory diseases of the visual organs.
Tablet dosage
How should I use thiotriazolin tablets? The instruction contains information that this drug should be taken only inside. As a rule, thiotriazoline is prescribed 1 or 2 tablets four times a day for 25-30 days.
The duration of therapy with this drug should be determined only by the doctor individually (depending on the characteristics of the course and severity of the existing disease).
Medicinal solution "Thiotriazolin": instructions for use
Thiotriazolin injections are given intramuscularly or intravenously. Their dosage is determined by the doctor (depends on the disease). With myocardial infarction and hepatitis, the drug is administered slowly intravenously, 2 ml 2-3 times a day. With cirrhosis, the drug is administered intramuscularly (2 ml 2-3 times a day). The course of treatment is 60 days.
Eye drops "Thiotriazolin": instructions for use
Thiotriazolin eye drops are instilled into the conjunctival sac. As a rule, the dosage for adults is 2 drops up to 4 times a day. As for children, the amount of medication is determined only by the pediatrician. The duration of treatment with eye drops should also be determined only by the attending physician.
As a rule, the duration of therapy with this agent is no more than 2 weeks. But if no improvement is observed, the course can be extended to a month.
In the event that the lesions of the visual organs are extensive and serious, then injections are additionally prescribed to the eye drops (alternating drugs).
To prevent drying of the membranes of the eyes (while working at the computer), it is necessary to use the medicine 2 drops per day with an interval of 2 hours.
Side effects
What side effects can the drug “Thiotriazolin” cause (injections)? The instruction for this tool suggests that this medication is relatively well tolerated. However, when using the drug in question, undesirable reactions can still occur.
- Central nervous system: dizziness, general weakness, tinnitus.
- Digestive tract: dry mouth, nausea, bloating.
- Vascular and heart: increased blood pressure, tachycardia, arrhythmia, pain in the heart.
- Respiratory system: asthma attacks and shortness of breath.
- Allergy: fever, hypersensitivity reactions, Quincke edema.
- Local reactions: redness and tingling sensation at the injection site.
- Dermatological reactions: hyperemia of the skin, itching, urticaria.
As for the eye drops, side effects were not observed on their part.
Drug interaction
According to experts, the drug "Thiotriazolin" can be used in combination with basic medicines intended for the treatment of coronary heart disease. This is due to the fact that the drug is a cardioprotective agent.
It should also be noted that this drug is allowed to be used simultaneously with drugs that are prescribed for the treatment of hepatitis of the corresponding etiology.
Thiotriazolin eye drops can be prescribed for pregnant women, as well as during lactation. It should also be said that the mentioned form of the drug is allowed to be used simultaneously with other medical devices.
Alcohol and the medicine "Thiatriazolin" enhance the effect of each other. In this regard, their simultaneous reception is prohibited.
special instructions
The composition of the tablets includes sucrose (in the amount of 2.8 mg in one tablet). Thus, the maximum daily dose of the drug may contain about 22.4 mg of this substance. Patients with diabetes need to know about this fact.
Methods and storage periods
Absolutely all forms of the drug “Tiatriazolin” must be stored in a dark place and inaccessible to children at a temperature of 14 to 26 degrees. The shelf life of the drug is 3 years.