In the article, we consider the instructions for "Progesterone" 2.5%.
It is a hormonal medicine used for replacement therapy in the field of gynecology in order to treat a variety of pathologies of the female reproductive system.
Pharmacological forms, composition
The manufacturer "Progesterone" is available in injectable form. The solution is used for parenteral administration. Externally, the drug looks like an oily liquid with a greenish or yellowish tint.
The main active ingredient in the solution is progesterone. The medicine may have a concentration of 1% and 2.5%. In Progesterone, additional substances are medical benzyl benzoate, ethyl oleate and other components.
Each carton contains 10 ampoules with an injection solution.
In what cases is prescribed "Progesterone" 2 ml of 2.5%?
Indications for use
A solution for parenteral administration is used to treat a variety of pathological abnormalities in the activity of the female reproductive system, including:
- Endogenous eczema, which is a pathology of the skin, with a hormonal etiology.
- A variety of psychotic disorders that occur in the postpartum period, severe pain.
- Toxicosis that occurs in the second half of pregnancy.
- Cystic mastitis in a chronic form, which is a pathology, which is characterized by the formation of small cavity cavities in the tissues of the mammary glands.
- Hypogenitalism is the underdevelopment of the female reproductive system.
- A familiar, threatening miscarriage.
- Lack of menstruation (amenorrhea).
- Bleeding from the uterus of dysfunctional origin.
In addition, the medication can be used as a contraceptive, which is aimed at preventing the onset of pregnancy.
Contraindications
Injections of "Progesterone" 2.5% are contraindicated to use if a woman has the following conditions or pathologies:
- Porphyrin disease.
- Incomplete abortion.
- A failed miscarriage.
- Vaginal (vaginal) bleeding having an unexplained etiology.
- High probability of blood clots.
- Acute forms of inflammatory processes in the venous walls, thromboembolic diseases that occur in acute forms.
- Hepatitis.
- Serious liver and kidney dysfunctions.
- Hypersensitivity to any of the components that are part of the drug.
In addition, an oil solution should not be used if:
- A woman is pregnant (from 14 weeks).
- A malignant formation in the genitals and breasts was diagnosed (for example, breast carcinoma, among the exceptions are cases when the medication is used as an element of complex therapy).
Negative impact
Therapy with hormonal drugs can provoke the development of allergic reactions.
In addition, injections of Progesterone 1 ml of 2.5% can cause the appearance of such negative symptoms as:
- Local manifestations (pain in the place where the solution was injected, redness of the skin).
- Tension, soreness, enlargement of the mammary glands.
- Galactorrhea (isolation from the mammary glands of milk, which is not associated with lactation and feeding the baby).
- Dysphoria, a violation of gender identity.
- Depression.
- Cholestatic hepatitis.
- Violation of the cycle of menstruation.
- Decreased appetite, resulting in weight loss.
- Vomiting, nausea.
- Hirsutism (a woman’s hair begins to grow according to the male type).
- Decreased libido.
- Alopecia.
- Visual impairment.
- Apathy.
- Headaches.
- Increased drowsiness.
- Chronic cholecystitis, which is characterized by the formation of calculi in the gallbladder (calculous cholecystitis).
- The occurrence of puffiness.
- Increased blood pressure.
- Thrombotic events in the blood vessels of the retina.
- Thrombophlebitis - thrombosis, which is accompanied by inflammatory phenomena in the venous network.
- Acute blockage of a blood clot by a blood clot.
Use of this medication
The drug hormonal solution should be administered intramuscularly. The single dose allowed for use is 0.025 g, which equals 1 ml of the solution if a medication with a progesterone concentration of 2.5% is used, or 2.5 ml if a solution with a concentration of 1% is used.
With caution, you should put progesterone injections in the presence of such conditions:
- Severe pathology of the heart and blood vessels (including hypertension and coronary heart disease).
- Bronchial asthma.
- Pathology of the nervous system (including epilepsy, migraine depressive states).
- Diabetes.
- Lactation (safety not proven).
Interaction of "Progesterone" with other medicines
When used together with Progesterone, there is a decrease in the activity of anabolic steroids, oxytoxic drugs, that is, drugs that can stimulate uterine contractions.
When used in parallel with bromocriptine, diuretics, antihypertensive drugs, immunosuppressants, systemic coagulants, their effect is enhanced.
Combination with drugs based on barbiturates leads to a decrease in the activity of Progesterone.
Analogues of the drug
If necessary, "Progesterone" 2.5% can be replaced by one of the analogues. The most popular are: “Prolutex”, “Ingesta”, “Ginprogest”.
Reviews on "Progesterone"
Most often, feedback on the experience of using Progesterone is found on resources dedicated to female infertility.
Often, women note the high effectiveness of the medication, even in cases where difficulties with conceiving and bearing a child are accompanied by multiple miscarriages. For many, "Progesterone" is the only way to save the pregnancy.
There are also negative reviews due to the fact that the drug often provokes the development of negative symptoms. Some women report that they did not at all notice the positive effect of using a hormonal solution.
That is, reviews of "Progesterone" 2, 5% are quite contradictory. Therefore, its use, like any other drug, must be agreed with the gynecologist.