Does a drug like Erexesil work? Reviews of men about the effectiveness of the drug in question will be considered at the end of the article. You will also learn about how you can replace the mentioned medication, in what form it is made and what pharmacodynamic properties it has.
Composition, description of the drug and form
"Erexesil" - tablets of blue color and oval shape, coated with a membrane (film). Their main active element is sildenafil citrate. Also, the composition of the medication includes the following auxiliary components: microcrystalline cellulose, croscarmellose sodium, calcium hydrogen phosphate and Mg stearate.
As for the blue shell, it consists of the blue Opadry II 85F20464 (i.e. polyvinyl alcohol, macrogol, titanium dioxide, talc, indigo carmine aluminum varnish).
On sale, the drug "Erexesil" (the reviews of men are more positive) comes in blisters that are packaged in packs of cardboard.
The principle of action of the drug
Erectile dysfunction is a problem of many modern men. Therefore, pharmaceutical companies are developing more and more new drugs designed to treat this condition. One of them is the Erexesil drug. Reviews of men report that this medicine is good and quickly enough restores impaired erectile function, and also provides a response to sexual arousal.
The effectiveness of this medication is due to its composition. Sildenafil is the active substance of this medicine. It is a selective and potent inhibitor of specific cGMP PDE5, which is responsible for the breakdown of cGMP in the cavernous body.
The mentioned component does not have a direct relaxing effect on the cavernous body, however, it significantly enhances the relaxing effect of NO on this tissue.
During sexual arousal, a local release of nitric oxide under the influence of sildenafil contributes to the inhibition of PDE5, as well as an increase in the content of cGMP in the cavernous body. As a result, there is an increase in blood flow and relaxation of smooth muscles.
Other features of the medication
What makes Erexesil tablets for men remarkable? The active ingredient in this medicine often causes a transient violation of the distinction between colors such as blue and green. Experts attribute this effect to the inhibition of PDE6, which is directly involved in the transmission of light in the visual organs.
Kinetic properties of the drug
What are the kinetic features of the drug "Erexesil", analogues of which are listed below? According to the instructions, after taking the medicine inside, its active component is absorbed very quickly. The absolute bioavailability of this drug is about 41%.
When taking sildenafil with fatty foods, its absorption rate is significantly reduced. The mentioned substance, as well as its main metabolite, bind to plasma proteins by 96%.
Sildenafil is metabolized under the influence of microsomal isoenzymes of the liver. Its half-life is about four hours.
Indications for appointment
Drugs for potency are very popular among those who suffer from erectile dysfunction. "Erexesil" is intended to treat a disease that is characterized by inability to achieve, as well as maintain an erection of the penis, sufficient for satisfactory sexual intercourse.
Thus, it can be safely noted that sildenafil is highly effective only with sexual stimulation.
Bans to use
In what cases can you not use drugs for potency? Erexesil tablets are contraindicated for use with:
- the simultaneous use of other drugs intended for the treatment of erectile dysfunction (the effectiveness and safety of sildenafil in such combinations have not been studied);
- continuous or periodic use of NO donors, organic nitrates or nitrites in any form (since sildenafil enhances the hypotensive effect of nitrates);
- at a minor age;
- concomitant use with ritonavir;
- high sensitivity of the patient to sildenafil or another component of the drug.
It should also be noted that the aforementioned tool is forbidden to appoint to women.
Cautious use
With caution, Erexesil tablets should be used for heart failure, anatomical deformation of the genital organ, diseases that predispose to the development of priapism, a tendency to bleeding, unstable angina pectoris, exacerbation of gastrointestinal ulcer, stroke, hereditary retinitis pigmentosa, myocardial infarction, threatening life, hypotension, arterial hypertension, ischemic neuropathy of the optic nerve.
Erexesil tablets: instructions for use
The medicine in question should be taken only by mouth. The recommended dosage of this drug for most adults is 50 mg 60 minutes before sexual activity. Given the tolerability and effectiveness of the drug, its dose can be increased to 100 mg or reduced to 25 mg.
The highest daily dosage of this medication is 100 mg, and the maximum recommended frequency of use is 1 time per day.
In older people, dose adjustment of the drug "Erexesil" is not required.
In the presence of moderate to moderate renal failure, dosage adjustment is also not required. As for severe renal failure, in this case, the dose of sildenafil is reduced to 25 mg.
Due to the fact that the excretion of the drug in question is impaired in people with liver damage, its amount should be reduced to 25 mg.
With simultaneous administration with ritonavir, the maximum single dose of sildenafil should not be higher than 25 mg, and the frequency of its use - 1 time in 2 days.
With the parallel use of the drug with inhibitors of the cytochrome CYP3A4 isoenzyme, its recommended initial dose is 25 mg.
In order to minimize the risk of postural hypotension in people who take alpha-blockers, the use of the drug in question should only begin after hemodynamic stabilization is achieved. Also in this case, the feasibility of lowering the initial dosage of sildenafil should be considered.
Side effects
What negative reactions can cause the drug "Ereksesil", the price of which is indicated below? The following instructions are indicated in the attached instructions:
- nasal congestion, headache, arthralgia, flushing, sinusitis, dizziness, rhinitis, insomnia;
- pharyngitis, dyspepsia, myalgia, change in vision, asthenia, respiratory failure, diarrhea;
- increased muscle tone, abdominal pain, conjunctivitis, nausea, respiratory tract infection;
- urinary tract infections, flu-like syndrome, back pain, the development of infectious diseases, priapism, symptoms of vasodilation, prostate gland dysfunction, rash.
The main signs of an overdose
With a single use of the drug in question in a dosage of 800 mg, undesirable reactions were comparable to those when taking the drug in lower doses, but they were much more common.
The main signs of an overdose with this drug include increased severity of side effects. If such occurs, symptomatic therapy is performed. It should also be noted that hemodialysis does not accelerate the clearance of sildenafil. This is due to the fact that the active substance "Erexesil" binds to plasma proteins and is not excreted by the kidneys.
Drug Interactions
How does sildenafil interact with other medicines? According to the instructions, the drug "Cimetidine" is able to increase the concentration of the substance in plasma by about 56%.
A single use of Erexesil together with erythromycin leads to an increase in AUC of the first by 182%.
With the parallel use of saquinavir and sildenafil, the maximum concentration increases by 140%, and AUC increases by 210%. Moreover, the substance in question does not have any effect on the kinetics of saquinavir.
Strong cytochrome CYP3A4 inhibitors such as Itraconazole and Ketoconazole contribute to serious changes in the pharmacokinetics of sildenafil.
A single dose of antacid does not affect the bioavailability of the drug in question. At the same time, sildenafil enhances the hypotensive effect of nitrates. In this regard, the use of this substance in combination with NO donors and nitrates is contraindicated.
In some sensitive people who receive alpha-blockers, concomitant use of sildenafil often leads to symptomatic hypotension.
The use of the considered tablets with antihypertensive drugs does not lead to the development of additional side effects.
What other interaction does the drug "Erexesil" have? Alcohol is prohibited when taking this medicine. Otherwise, the effectiveness of this drug is significantly reduced.
additional information
Before you start taking Erexesil, you need to conduct a thorough examination of CVS.
The drug in question should not be used in people for whom a sexual act is undesirable.
With caution, these tablets are prescribed for people with a tendency to bleeding.
Sildenafil has no effect on a man’s ability to drive vehicles and drive other mechanisms.
Analogs and cost of funds
Such drugs as Viagra, Tornetis, Viasan-LF, Taxiere, Viatail, Sildenafil, Vigrande, Silafil, Vizarsin, Vizarsin, and others refer to the analogues of the Erexesil medication; Ridzhamp ”,“ Vildegra ”,“ Revazio ”,“ Dynamo ”,“ Olmax Strong ”,“ Maxigra ”and others.
How much is the drug in question for the treatment of potency disorders? The price of this medicine in different pharmacies may vary. However, its average cost is approximately 715 rubles (for 4 tablets, 50 mg).
The drug "Erexesil": reviews of men
What do the stronger sex say about a drug like Erexesil? Most of the reviews about the medication in question are exclusively positive. Men claim that this is a highly effective drug designed to quickly restore impaired erectile function, as well as provide a natural response to sexual arousal. It is enough to use only one Erexesil tablet, as the strong sex immediately notes its effective effect.
As for the negative messages about this drug, most often they say that this medication can cause many side effects. In addition, some patients are unhappy with the high cost of this product, given that there are only four stimulant pills in a cardboard box.