What is a tool like Instenon? Instructions for use, the price and properties of this medication will be described later.
Composition, form, description of the drug
In what form is the aforementioned drug sold? What do consumer reviews say about this? Instenon is available in the following forms:
- The tablets are round with a shiny and even surface, coated with a white shell. The main substances in their composition are: hexobendine (in the form of hexobendine dihydrochloride), as well as etofillin and ethamivan. In addition, this medicine contains additional elements: talc, magnesium stearate, pregelatinized starch, corn starch and lactose monohydrate.
- Transparent and colorless Instenon solution (injections), intended for intramuscular or intravenous administration. Its active ingredients are also hexobendin (in the form of hexobendin dihydrochloride), etofillin and ethamivan. As for excipients, disodium edetate, water d / and and propylene glycol are used as them.
Pharmacology
How does the drug in question work? What do the medical reviews say about this? "Instenon" is a combined medication that improves metabolism, as well as blood circulation in the brain.
The effectiveness of this medicine is due to the properties of its basic substances. Let's consider them in more detail.
Due to the activation of the reticular formation, ethamivan is able to normalize the work of neural subcortical-stem structures and complexes of the cortex.
Hexobendin improves and accelerates the utilization of glucose and O2 by activating pentose cycles and anaerobic glycolysis. This happens only in conditions of oxygen starvation and ischemia, when oxidative aerobic phosphorylation is significantly impaired. Stimulation of anaerobic oxidation is carried out by an energy substrate for the purpose of exchange and synthesis of mediators, as well as restoration of synaptic transmission.
It cannot be said that hexobendin is able to stabilize the mechanisms (physiological) of blood flow autoregulation (cardiac and cerebral), which is directly related to the effect of pyruvate and lactate (that is, anaerobic glycolysis products) on capillary receptors and intracranial arterioles.
What role does etophylline play in Instenon? Instructions and reviews report that this substance activates myocardial metabolism and increases cardiac output, which further contributes to an increase in pressure (perfusion) in ischemic vessels. In this case, systemic blood pressure does not change.
The excitatory effect of etophylline on NS is also manifested by stimulation of the midbrain and other subcortical formations, as well as stem nuclei and centers (including FMN nuclei, the center of autonomic regulation, vasomotor and respiratory centers and the vagus nerve).
When using the Instenon medication, the analogues of which are listed below, in cases of trauma to the cranial box and brain (closed), ischemic stroke, the elimination of neurological disorders, restoration of the patient’s consciousness and activation of the autonomic system are noted.
Indications
In what conditions is the medication in question the most effective? What do the reviews say about this? "Instenon" is indicated for use in:
- post-stroke conditions;
- diseases of the brain of vascular origin, as well as associated with age-related changes in the patient;
- insufficiency of blood supply to the brain and its consequences;
- dizziness caused by a (functional) brain disorder.
Bans to use
The medication "Instenon" (injections and oral forms of the drug have the same contraindications) is forbidden to prescribe for:
- convulsive syndrome;
- state of strong excitement;
- symptoms of high blood pressure (intracranial), including prolonged headache, vomiting, and visual impairment;
- epilepsy;
- cerebral hemorrhages;
- hypersensitivity to the ingredients of the drug.
With caution, the medication in question should be used after a stroke, as well as with arterial stenosis (carotid), arising from arteriosclerosis.
The drug "Instenon": instructions for use
The price of this medication is about 350-400 rubles. How should i use it? Depending on the severity and type of disease, the agent in the form of a solution is administered intramuscularly or slowly intravenously. To do this, apply 1 ampoule of the drug 2 times a day.
Also, the medication can be prescribed in the form of a drip intravenous infusion. In this case, it is also prescribed 1 ampoule 2 times a day together with 250 ml of a 5% solution of levulose.
After improving the patient's condition, therapy can be continued with the oral form of the drug. In this case, the tablets are taken orally in an amount of 1-2 pieces three times a day. The maximum daily dosage of this product is 5 tablets. Such therapy is carried out for six weeks.
Side effects
According to experts, the drug "Instenon" quite rarely causes negative reactions. In some cases, when it is used in high dosages, the patient may experience a headache, as well as a decrease in blood pressure and hyperemia on the skin of the face.
Overdose and interaction
Signs of an overdose with this remedy are headaches, facial flushing, and tachycardia. To eliminate such conditions, you should cancel the drug, and then resume its use, but at a lower dosage.
With the parallel use of the Instenon medication and agents that reduce platelet activity (including acetylsalicylic acid), an increase in the antiplatelet effect is possible due to the influence of hexobendin.
When taking caffeine in large doses, the therapeutic effectiveness of Instenon may be reduced.
Special information
What should patients know before taking the medication in question? According to the attached instructions, sometimes with rapid intravenous administration of "Instenon" in a patient, blood pressure decreases significantly. In this regard, the duration of the infusion of the first dose should not be less than three minutes.
During treatment with this product, the patient must be extremely careful when working with dangerous machinery and driving a car.
Similar medicines and reviews
“Instenon” can be replaced by such means as “Cytoflavin”, “Armadin”, “Glycine”, “Boluses Huato”, “Keltikan”, “Mexidol”, “Cortexin”, “Mexiprim”, “Nucleo CMF Forte”, “Neurotropin "," Tryptophan. " It should be noted that these drugs have their own indications and features, therefore, only an experienced specialist should prescribe them.
What do consumers say about the medicine in question? According to their claims, this medication rarely contributes to the development of any complications, so it is prescribed even for children. Its intake significantly improves cerebral circulation, and also eliminates other problems with blood vessels.
The only drawback of this drug is the quick adaptation of the body to the drug. In this regard, we can safely say that "Instenon" is a course tool that is not intended for continuous use.