The drug "Ceftazidime" refers to the group of third generation cephalosporin antibiotics. The medication has a fairly wide spectrum of action. The drug has bactericidal activity due to inhibition of the synthesis of the bacterial cell wall . The tool acts on anaerobes, gram-negative, aerobes and gram-positive bacteria. The drug is active against strains resistant to methicillin, ampicillin, cephalosporins and aminoglycosides. The tool binds to proteins by 10-17%, is well distributed in fluids and in body tissues. The medicine is able to penetrate the placental barrier, is found in milk. The drug reaches therapeutic concentrations in the cerebrospinal fluid. A small amount of medication penetrates the bile. Excretion from the body is carried out unchanged in the urine (mainly).
The medicine "Ceftazidime." Instructions for use. Indications
The medicine is prescribed for infectious and inflammatory pathologies of organs and tissues, provoked by pathogens that are sensitive to it.
Contraindications
The tool is not recommended for intolerance to its components, as well as other cephalosporins. The appointment of the drug to pregnant or lactating patients is carried out strictly according to the indications. Caution should be observed in the treatment of patients with impaired renal activity, newborns. Persons with penicillin intolerance are likely to develop an allergy to cephalosporin antibiotics. Dosage adjustment may be necessary while using the drug with aminoglycosides and loop diuretics.
Means "Ceftazidime". Instructions for use: adverse reactions
The medication can provoke Quincke's edema, pseudomembranous colitis, vomiting, candidiasis, hypoprothrombinemia. Due to therapy, diarrhea, nausea, interstitial nephritis, soreness at the injection site, and phlebitis sometimes occur. To the negative consequences of using Ceftazidime in high doses, the instructions for use include changes in the picture of peripheral blood. In particular, neutropenia, hemolytic anemia, leukopenia, thrombocytopenia are likely.
Dosage regimen
Means "Ceftazidime" instructions for use recommends to be administered intravenously or intramuscularly. For adults, the dosage is 0.5-2 grams every eight or twelve hours. Maximum per day is allowed no more than 6 grams. Children from 1 month to 12 liters are prescribed 30-50 mg / kg / day. The frequency of administration is no more than three times a day. Children up to a month of life are prescribed 30 mg / kg / day. The amount of the drug is divided into two injections.
The medicine "Ceftazidime." Instructions for use. Price. additional information
The cost of the medicine is within one hundred rubles. When combined with a number of drugs that have a nephrotoxic effect, the drug Ceftazidime potentiates this activity. Use the medicine only as directed by the doctor.