According to the instructions, Bereta tablets are anti-ulcer drugs and are an inhibitor of N-K-ATPase or proton pump. This drug acts by inhibiting the enzyme N-K-ATPase in the parietal gastric cells, as a result of which the final stage of the occurrence of hydrochloric acid is blocked. Such an action is characterized by dose dependence and inhibits not only basal, but also stimulated secretion of hydrochloric acid, regardless of the nature of the stimulus.
Form, packaging and composition
"Bereta" is a drug used for acidity disorders. It is produced in the form of biconvex round tablets having a shell that dissolves in the intestine. In addition, on their cross section two layers are represented. Color - yellow with a grayish tint. It is produced by the pharmaceutical company Veropharm (Russia).
The active substance of the drug is sodium rabeprazole, additional components are substances of low-substituted hyprolose and low-grade hyprolose, mannitol, magnesium stearate and magnesium oxide. The inner shell contains magnesium oxide and ethyl cellulose.
The intestinal dissolving shell contains yellow acrylic with methacrylic acid copolymers included in it, and colloidal titanium dioxide and silicon dioxide, yellow iron dye, sodium lauryl sulfate, sodium bicarbonate, triethyl citrate. This confirms the instructions for use for Beret tablets. Analogs will be presented below.
It is sold in pharmacies in cardboard packs with enclosed contour packs containing seven and ten tablets. There are either two packs in a pack, or one, but containing fourteen tablets. In addition, they contain a polymer bottle with twenty or fourteen tablets.
The drug is allowed to be stored for two years after its manufacture. The temperature should not be higher than twenty-five degrees. Access to the place where the drug is stored should be limited to children. What else does the instruction report for Beret tablets? Let's figure it out.
Pharmacology
The drug "Beret" - a tool used against ulcers and acting as an inhibitor of the proton pump. The mechanism of the drug’s functioning is based on a process under the influence of which the pump enzyme is inhibited in a particular gastric region, and as a result, the final stage of acid formation is blocked.
Pharmacokinetics
After taking the medicine "Beret", it is absorbed from the digestive tract. The therapeutic effect of a dose of twenty milligrams culminates in three and a half hours. Bereta is about fifty-two percent bioavailable as it passes through the liver. But repeated use of the drug does not contribute to increased bioavailability. This points to the "Beret" pills instruction.
The absorption of the drug is also not affected by the time of its intake and food.
A component such as rabeprazole accounts for ninety-seven percent for binding to plasma proteins. The metabolism of this drug is carried out in the liver with the participation of some isoenzymes.
In elderly patients, rabeprazole is excreted more slowly. What are the indications of the tablets "Beret"? This will be discussed later.
Indications for use
The drug is prescribed to patients suffering from peptic ulcer of the stomach, as well as the duodenum. It is especially recommended for their exacerbations. Most often taken in combination with certain antibiotics. In addition, this drug is prescribed in the presence of gastroesophageal reflux in children.
Contraindications
The drug should not be used by pregnant women and nursing mothers, as well as patients who have a specific sensitivity to the main components of the drug.
Instructions for use of the drug
According to the instructions, Beret tablets are indicated for internal use, while a single dose can be from ten to twenty milligrams. Depending on the individual characteristics of the disease, the doctor will prescribe a treatment regimen for the patient.
Negative effects
"Bereta" has a very impressive list of side effects from their use, and they must be taken into account in the process of prescribing this drug to the patient.
The digestive system can respond as follows:
- bouts of nausea, diarrhea, vomiting, pain in the abdomen, constipation, flatulence;
- dry mouth may be less likely, belching and dyspepsia appear;
- in isolated cases, gastritis, anorexia, stomatitis and an increase in liver transaminase activity were noted.
The nervous system can respond with the following reactions:
- headaches, insomnia, dizziness, asthenia;
- less often - drowsiness, nervousness;
- in very rare cases - by defects in taste and visual, depression.
From the respiratory system:
- rhinitis, cough, pharyngitis may appear;
- in more rare cases, bronchitis, sinusitis are possible.
Allergic reactions:
- very rarely skin rashes may appear;
- in isolated cases, itching may occur.
Other side effects:
- pain in the back, flu-like syndrome;
- very rarely - chest pain, muscle cramps, chills, myalgia;
- in isolated cases, increased sweating or the occurrence of leukocytosis, weight gain are recorded.
The nature of the interaction with other drugs
If you take Bereta tablets at the same time as ketoconazole, then its bioavailability will decrease. If you take them together with digoxin, then it is possible to increase the concentration of this drug in plasma.
Effects on the level of gastrin in the plasma
During clinical trials, patients received ten or twenty milligrams of rabeprazole sodium every day. The duration of therapy is up to forty-three months. At the same time, an increase in plasma gastrin level was observed during the first two to eight weeks, which is an indicator of the inhibitory effect on acid secretion. The concentration of gastrin returned to its initial state mainly one to two weeks after completion of therapy. This is important in the treatment of gastroesophageal reflux in children.
Effect on enterochromaffin-like cells
During the analysis of biopsy samples of the human stomach from the antrum and gastric fundus in five hundred patients who received rabeprazole sodium or a comparison drug for eight weeks, no stable changes were found in the morphological structure of the severity of gastritis, intestinal metaplasia, atrophic gastritis or prevalence Helicobacter pylori bacteria.
With the participation of more than four hundred people who took rabeprazole sodium ten or twenty milligrams a day for one year, a low incidence of hyperplasia was observed, which was similar to that for omeprazole (twenty milligrams per kilogram). There were no cases of adenomatous transformations or carcinoid tumors that were observed in rats.
Some recommendations
Before starting therapy, it is necessary to eliminate the presence of malignant gastric neoplasms, since the use of rabeprazole is able to mask the characteristic symptoms and postpone the correct diagnosis for some time. If the patient has defects in the functioning of the kidneys or liver, there is no need to adjust the dose, with severe violations of the liver, rabeprazole should be used with caution.
If digoxin and ketoconazole are taken at the same time as rabeprazole, the doses must be adjusted.
No carcinogenic effect of rabeprazole was established under experimental conditions, but ambiguous results were noted during the study of mutagenicity. In mice, tests for lymphoma cells gave a positive result, while in vitro and in vivo DNA restoration tests and in vivo micronuclear tests were negative. This confirms the instructions for use for Beret tablets.
Analogues of the drug
Tablets have similar drugs, similar in pharmacological effect, but their cost is much higher. These include the following medicines:
- Zulbeks.
- "Soars."
- Noflux.
- Ontime.
All of these products are also available in tablet form.
Manufacturer of the drug "Bereta"
The manufacturer of this medicine is OJSC Veropharm (Russian Federation). This joint-stock company manages all stages, including the issuing quality control. The pharmaceutical substance, namely rabeprazole sodium, is produced by the Indian manufacturer Nosh Labs Private Limited. Consider what kind of reviews there are about Beret tablets.
Reviews
It is worth noting that there are not too many reviews on the Bereta drug, and therefore it is quite problematic to draw any definite conclusion about the effectiveness of the effect of this drug, as well as the safety of its use. However, reviews of rabeprazole, which is an active ingredient, suggest that this drug should act fairly quickly, even if small doses are used. The undoubted advantage of Beret tablets is the small number of side effects and the widely available cost in comparison with the price of analogues.
A positive effect of the drug on acidity and a decrease in reflux is noted. Quite well, it helps to correct hemorrhagic gastritis. In some reviews, the temporary nature of the effect of the drug is noted, in such cases a course of other tablets was required.
Price
“Bereta” differs from similar expensive medicines in that it has a fairly reasonable cost, which averages no more than two hundred and fifty rubles.