Do you know what helps a drug like Losek MAPS? Instructions for use, as well as the indications of this medication will be described in this article. In addition, we will tell you about how much the mentioned remedy costs, whether it has analogues and contraindications, what side effects occur after administration and so on.
Composition, packaging and form of the drug
What is the medicine "Losek MAPS"? Instructions for use inform us that this drug is available only in tablet form. The active element of the drug is omeprazole (10, 40 or 20 mg). The tablets also include auxiliary components: glyceryl monostearate, MCC, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, magnesium stearate, sugar, methacrylic acid copolymer, talc, paraffin, triethyl citrate, polyethylene glycol, titanium dioxide, polysorbate, sodium ferrous nitride, .
You can buy medication in bottles of 14, 7 or 28 tablets (10, 40 or 20 mg), placed in a cardboard box.
Pharmacodynamics
How does the drug Losek MAPS work? Instructions for use states that this drug is an inhibitor of H + -K + -ATPase. Moreover, it relates to antiulcer drugs. Its active substance is a weak base. It is concentrated in the acidic environment of the parietal cells of the gastric mucosa, activating and inhibiting the proton pump.
The effect of omeprazole on the described process is dose dependent. The drug is able to provide highly effective inhibition of stimulated and basal secretion of hydrochloric acid, regardless of the stimulating factor.
Effect on the secretion of gastric juice
With daily oral administration, the drug Losek MAPS, the price of which will be presented a little further, provides effective and rapid inhibition of night and day secretion of hydrochloric acid. The greatest therapeutic effect is observed within 4 days of treatment. In people with a duodenal ulcer, 20 mg of the drug causes a steady decrease in 24-hour acidity of the stomach by at least 80%. It should also be noted that the specified dose of the drug is able to maintain in the intragastric medium a pH level of pH> 3. This effect persists for 17 hours.
Effect on Helicobacter pylori
How effective is the drug “Losek MAPS” in relation to the mentioned bacteria? The instructions attached to the drug indicate that omeprazole has a high bactericidal effect on Helicobacter pylori. The eradication of this bacterium during the use of the drug in combination with antibacterial drugs is accompanied by a fairly rapid elimination of all symptoms, as well as a high degree of healing of the affected gastrointestinal mucosa. In addition, this treatment contributes to prolonged remission of peptic ulcer disease, which significantly reduces the likelihood of repeated bleeding.
Other properties of the drug
What other properties does a drug like Losek MAPS have? Reviews of experts say that in patients who regularly and for a long time take medications that lower the secretion of the glands of the digestive tract, glandular cysts are often observed in the stomach. As a rule, they are benign and pass on their own.
Reducing the secretion of hydrochloric acid in the stomach contributes to the normal intestinal microflora. However, this can lead to a slight increase in the risk of developing infections.
In adults and children who have been taking the drug for a long time, an increase in the number of enterochromaffin-like cells is observed.
During treatment with omeprazole, the concentration of gastrin in the blood increases slightly.
Pharmacokinetics
Is the drug Losek MAPS absorbed into the bloodstream? Instructions for use states that the absorption of omeprazole occurs in the small intestine (within 4-6 hours). Eating does not affect the bioavailability of this substance. After oral administration, it is about 60%.
The drug is completely metabolized in the liver. The elimination half-life makes about 30-80 minutes. Approximately 80% of the active substance is excreted as metabolites through the kidneys, and the rest with feces.
Indications
Losek MAPS tablets are prescribed for the following deviations:
- stomach ulcer;
- reflux esophagitis;
- duodenal ulcer;
- erosion of the digestive tract caused by NSAIDs;
- Helicobacter pylori eradication;
- dyspepsia, which is associated with increased acidity;
- gastroesophageal reflux disease (symptomatic);
- Zollinger-Ellison syndrome.
Contraindications
The drug "Losek MAPS" can not be prescribed for patients with hypersensitivity to omeprazole, as well as substituted benzimidazoles or other ingredients that are part of the drug.
It should also be noted that this medication is prescribed with caution to people in the presence of signs such as spontaneous weight loss, dysphagia, frequent vomiting and vomiting with blood. In addition, with a stomach ulcer (or suspected illness), it is necessary to exclude the presence of a malignant tumor. This is due to the fact that treatment with omeprazole can easily mask the symptoms of the disease and delay the correct diagnosis.
How to take the medicine "Losek MAPS" (20 mg)?
The drug in question should be taken only orally in the morning. The medicine must be swallowed whole, washed down with water. The drug can not be crushed or chewed.
The tablets may be dissolved in slightly acidified liquid or water (for example, in fruit juices). However, the resulting solution must be drunk within half an hour.
With esophageal reflux, a stomach ulcer, as well as a duodenal ulcer, the drug is prescribed 20 mg once a day. With reflux esophagitis, the dose is doubled.
The duration of treatment for ulcers is 2-4 weeks, for reflux esophagitis - 4 weeks, and gastroesophageal reflux - 4-8 weeks. To prevent recurrence of ulcers and reflux esophagitis, a longer dose of 10 mg can be prescribed.
Side effects
The medicine "Losek MAPS", analogues of the drug can cause side effects. The most common pathological conditions are: headache, flatulence, abdominal pain, constipation, diarrhea, nausea, and vomiting.
Infrequent side effects include: dermatitis, urticaria, dizziness, itching, paresthesia, rash, malaise, drowsiness, increased activity of liver enzymes and insomnia.
Quite rarely, patients taking omeprazole experience hypersensitivity reactions (for example, anaphylactic shock, fever, anaphylactic reaction, angioedema), as well as bronchospasm, hepatitis, muscle weakness, liver failure, leukopenia, encephalopathy, arthralgia, pancytia, mi thrombocytopenia, agitation, agranulocytosis, dry mouth, hyponatremia, gastrointestinal candidiasis, aggression, photosensitivity, confusion and blurred vision, hallucinations, sweating, taste disturbance, Periph -geometric edema, stomatitis, interstitial nephritis, alopecia, gynecomastia, erythema multiforme, microscopic colitis, Stevens-Johnson syndrome and toxic epidermal necrolysis.
Very rarely hypocalcemia, hypomagnesemia, hypokalemia, and hypomagnesemia are observed.
The medicine "Losek MAPS": price and analogues
Compared with similar drugs, the price of the drug in question is quite high. So, for 14 tablets you will have to give about 250 Russian rubles. Given the long-term use of the medication (from 2 to 8 weeks), their treatment is too expensive.
What is the substitute for the drug Losek MAPS for? Analogues of this tool have the same effectiveness. However, before using them, you should always consult a doctor.
So, you can replace the Losek MAPS medicine with the following drugs: Omeprazole-Acre, Vero-Omeprazole, Cisagast, Gastrozole, Helol, Demeprazole, Helicid, Zhelkizol, Ultop ”,“ Zerocide ”,“ Ulkozol ”,“ Zolser ”,“ Ulzol ”,“ Crismel ”,“ Sopral ”,“ Losek ”,“ Romesek ”,“ Omez ”,“ Promez ”,“ Omez D ”,“ Pleom- 20 ”,“ Omez Insta ”,“ Pepticum ”,“ Omezol ”,“ Ocid ”,“ Omecaps ”,“ Orthanol ”,“ Omeprazole ”,“ Omitox ”,“ Omeprazole-Richter ”,“ Omipixol ”,“ Omeprazole Stada ” , Omizak, Omeprazole Zentiva, Omefez, Omeprazole Sandoz, Omeprus, Omeprazole-OBL, Omeprazole-FPO , Omeprazole-Teva, Omeprazole-AKOS.
Patient Reviews
What do patients say about Losek MAPS? Reviews about this tool are extremely positive. According to those who have ever taken the medication mentioned, it quite effectively eliminates all the symptoms of increased acidity of the gastric juice. Moreover, the result is noticeable almost immediately after taking the tablets (after 1-2 hours).
Often, the drug in question is used for heartburn and a burning sensation behind the sternum.
Despite the high effectiveness of the drug, most patients complain that after stopping it, discomfort returns. In this case, doctors recommend a comprehensive treatment and use the medication for at least four weeks.