In the article, we consider the instructions for use with calcium dobesilate.
Preparations based on it contribute to the normalization of vascular wall permeability, and also establish microcirculation, disturbed by pathologies of the cardiovascular system and metabolism, increase the strength of capillaries. Medicines with calcium dobesylate in the composition reduce blood viscosity, reducing platelet aggregation.
The therapeutic effect of the drugs is due to a decrease in the activity of kinins in blood plasma, as well as an increase in platelet activity, which has a positive effect on the strengthening of the choroid. This is confirmed by the instruction for calcium dobesilate.
The composition of this medication
In pharmacies, you can find different forms of calcium dobesilate, including capsules and tablets. The drug can be packaged in both contour cells and dark glass vials.
The composition of the drug includes the active substance, represented by calcium dobesilate monohydrate. This is a crystalline powder of white color, which may have a pinkish or cream tint.
Drug properties
According to the instructions for calcium dobsylate, the main feature of the active component is the normalization of the microcirculation system. This makes it possible to include the drug in the treatment of pathologies of the heart and blood vessels, restoring their normal functioning. The drug helps to normalize the patency of the vascular walls, slightly dilutes the blood, making it less viscous, and also prevents the formation of blood clots, which under certain circumstances can block the lumen of the artery. In addition, the use of drugs based on calcium dobsylate increases the strength of capillaries.
The main pharmacological properties of the drug are:
- Gyroscopicity.
- Good water solubility.
- The possibility of dissolution in 95 percent alcohol.
- Calcium dobesilate is excreted from the body by the kidneys, as well as with feces during the day after administration.
- Slow absorption. The maximum concentration of a substance in the blood is recorded six hours after taking the drug.
- The substance is excreted in small amounts with breast milk.
Indications for the use of this medication
As the instructions indicate, calcium dobesilate is used for violation of blood circulation, as well as vascular permeability and against metabolic diseases, including:
- Postthrombotic and postphlebitic syndrome.
- Varicose veins, which is accompanied by a violation of the flow of blood into the vessels.
- Trophic ulcers, which are a violation of the integrity of the skin or mucous membrane. The disease often recurs, ulcers heal slowly. Trophic ulcers are formed due to rejection of necrotic tissue.
- Atherosclerotic lesion of blood vessels on the legs, which is accompanied by a narrowing of the vascular lumen.
- Hemorrhagic syndrome, against the background of which bleeding increases.
- Hormone-dependent variety of bronchial asthma.
- Diabetic-type retinopathy, which is characterized by damage to the retina of the eye against a background of high blood sugar.
- Peripheral edema due to accumulation of fluid in the subcutaneous tissue.
- Superficial phlebitis, accompanied by an inflammatory process in the veins.
- Hemorrhoids.
- Microangiopathy caused by pathologies of the heart and blood vessels.
- Arteritis of unspecified origin, which is an immunopathological inflammation of the vessels.
- Thrombophlebitis.
Instructions for use of the drug
Calcium dobesilate is a medication intended for oral administration. This medicine is taken with meals or immediately after. Tablets, like capsules, are swallowed whole, they do not need to chew or grind.
The drug is taken up to four times a day at 250 mg. As maintenance therapy, the drug is used at 250-500 mg per day.
If the patient has a history of gouty arthritis in a severe form, it is prescribed the following dosage regimen: 500 mg in the morning, then 250 mg twice for four hours. In the following days, an increase in dosage to 1 gram is allowed.
If the patient has retinopathy, the drug is prescribed in a dosage of 250 mg up to three times a day. The duration of treatment can reach six months. In the future, a dosage reduction to a maintenance component of 250-500 mg per day is allowed.
Adverse reactions from the use of the drug
According to the instructions for use with the drug, calcium dobesilate, taking the drug can lead to the following undesirable reactions:
- Dyspeptic disorders.
- Allergic reactions in the form of a rash.
- Increased activity of liver transaminases.
Other side effects
In addition, a number of reactions stand out that are much less common than those listed above:
- General malaise, fever, chills.
- Disorders of the lymphatic and circulatory systems, in particular, manifested by agranulocytosis. This side effect is reversible and disappears on its own after discontinuation of the drug.
- Violation of connective tissues, as well as structures of muscles and skeleton, accompanied by arthralgia.
If these adverse reactions are identified, you should refuse to take calcium dobesilate. If treatment cannot be interrupted, you need to consult a doctor about adjusting the dosage taken in the direction of reducing or selecting another drug.
No cases of overdose have been identified to date.
Contraindications
Tablets of calcium dobsylate are not recommended for use in the following conditions and pathologies:
- The first trimester of pregnancy.
- Hypersensitivity to the components that make up the drug.
- Hemorrhage as a result of taking substances that affect blood coagulation.
- Peptic ulcer of the stomach and duodenum in the acute stage.
- Age is under 13 years.
A categorical ban is imposed on taking the drug at the beginning of the gestational period. Subsequently, calcium dobesylate is allowed, but with caution and only after consultation with the attending physician.
Studies have shown that in small amounts, calcium dobsilate is able to penetrate into breast milk and, accordingly, into the baby’s body. Doctors advise either to abandon drug therapy during lactation or to stop breastfeeding during treatment with subsequent resumption.
It is not recommended to take the drug on the background of pregnancy and breastfeeding. Dosage and duration of administration are also consistent with the doctor.
In the instructions for calcium dobesylate, analogues are not indicated.
Analogues of this drug
The most common drugs based on calcium dobesylate are the following:
- Doxy Hem. An angioprotector used to prevent thrombosis, as well as for various pathologies of the heart and blood vessels. The cost is an average of 250 rubles.
- Esculex It is produced in the form of capsules of 30 pieces in one package. The drug is prescribed as a prophylactic for varicose veins.
- "Vatsirtron." It is also produced in the form of capsules of 30 and 60 pieces in one package. The appointments are similar.
There are a large number of calcium dobesylate analogues that can replace the original. As a rule, their cost is higher, but the action is absolutely identical. Sometimes there is an allergic reaction to certain components, so doctors are forced to select analogues based on another active component. They can become:
- "Troxerutin."
- "Flebodia 600".
- Ascorutin.
- Kaptopres, etc.
You can’t change drugs on your own, you must definitely get a specialist consultation.
Calcium Dobesilate Reviews
Doctors, like patients, invariably respond well to the effects of calcium dobsilate on the body. Neurosurgeons often prescribe the drug to patients with circulatory disorders of the brain. Patients positively comment on the speed of action and effectiveness of the drug. He helped some to eliminate hemorrhoids, others relieved of the unpleasant manifestations of varicose veins, as well as trophic ulcers.
Women in reviews recommend taking the drug to those who cannot imagine life without high heels. They believe that pills help relieve swelling and pain in the legs, as well as strengthen blood vessels and prevent the development of varicose veins.
The practical use of calcium dobesylate has confirmed its relative safety. There are practically no reviews on the Web about the negative effect of the drug on the body, side effects are extremely rare and, as a rule, are the result of non-compliance with the doctor’s instructions or instructions.
Calcium dobesilate helps to normalize vascular permeability, improves blood circulation, and also reduces swelling. The drug is considered inexpensive and is available in many pharmacies. You can buy it without providing a prescription from a doctor. However, you should not use the drug uncontrollably and without consulting a specialist, as this can lead to a deterioration in the condition and the appearance of adverse reactions from the body.