The composition of acriderm includes the antibiotic gentamicin of the aminoglycoside group, which has a wide spectrum of action. Bactericidal effect on many microorganisms. Ointment "Akriderm" also contains betamethasone, which is a glucocorticosteroid. This substance has anti-allergic, decongestant and local anti-inflammatory effects. Clotrimazole, which is part of the drug, has an antifungal effect. This imidazole derivative acts by disrupting the synthesis of ergostirol, which is one of the components of the cell membrane of fungi.
Transdermal absorption of the active substance into the blood slightly
with cutaneous use of the drug in therapeutic doses. Intensity
absorption of betamethasone when applied to the skin is largely dependent on
epidermal barrier. Skin diseases and inflammation significantly
increase the absorption of betamethasone. Ointment "Akriderm" when using occlusive dressings can cause the development of systemic side effects.
Indications for use of the drug are allergic and simple dermatitis, diseases complicated by secondary infection. Ointment "Akriderm" is used to treat limited and diffuse neurodermatitis, including atypical. A medication is indicated for the treatment of simple chronic lichen, eczema, and dermatomycosis. A good therapeutic effect Acrederm ointment gives in cases of multi-colored lichen, candidiasis and dermatophytosis, especially when areas of large folds on the skin, in particular, groin, are affected.
The product is applied to areas of the skin using light rubbing. The duration of therapy depends largely on the severity of the lesions and the nosological form
diseases. With dermatomycosis of the legs, the course of therapy is 3-4 weeks. When,
if clinical changes are not observed, it is recommended to change the treatment regimen or to clarify the diagnosis. If fungal or bacterial microflora occurs, it is necessary to cancel the use of Acriderm ointment and prescribe the appropriate treatment. The drug is recommended to be used with great care for children, since they still have poorly developed epidermis and a large area of skin in relation to body weight. "Akriderm ointment", reviews of which can be found on specialized sites, can cause adverse systemic manifestations in children. In this regard, the drug is used, observing all safety precautions and as soon as possible. Caution should be exercised when using the drug for pregnant women and nursing mothers.
Side effects of Acriderm ointment can be expressed in allergic reactions, hypopigmentation, the appearance of steroid acne, hypertrichosis, folliculitis, dry skin. Akriderm Genta Ointment can cause dry skin, irritation, and itching. When applying occlusive dressings, there is a risk of developing sweating, skin atrophy, infection and maceration. When applied on a large surface and with long-term treatment, there is an increase in blood pressure and body weight, dysmenorrhea, hyperglycemia, exacerbation of hidden foci of infection. Side effects can occur in osteoporosis, edema, ulceration of the mucous membranes of the gastrointestinal tract.
Interaction "Acriderma" with other drugs was not found.
Contraindication to the use of ointment is tuberculosis of the skin, children
age, open wounds, post-vaccination skin reactions, herpes, chickenpox,
manifestations of syphilis symptoms on the skin. With an overdose of the drug, possible
manifestations of hypercorticism. The treatment in this case is correction
electrolyte disturbances, symptomatic therapy and gradual withdrawal
medicinal product.