This article will present instructions for use with Nolitsin 400 mg.
It is the trade name of Norfloxacin, an antibacterial drug in the fluoroquinolone category. This medicine has a tablet form of release, it is produced by the Slovenian pharmaceutical company Krka. The content of the active substance norfloxacin in one tablet is 0.4 grams. The cost of packaging ranges from two hundred to three hundred and seventy rubles. Instructions for use with Nolitsin are very detailed.
Pharmacological action of the drug
"Nolicin" is an antimicrobial drug from the category of fluoroquinolones, it has a wide range of effects. First of all, Nolitsin can have a bactericidal effect on the body. This drug affects bacterial enzymes that provide supercoiling, so this medication contributes to the stability of bacterial DNA. The duration of antimicrobial exposure is approximately twelve hours.
Pharmacokinetics of the drug
According to the instructions for use with "Nolitsin", after taking the medicine, its active substance norfloxacin is fast enough, but not fully absorbed from the digestive system. The highest concentration is observed after two hours. Food intake may slow the absorption of the drug.
Due to the low binding of norfloxacin to plasma proteins and its high solubility in lipids, the drug penetrates well into organs. The drug is excreted by the kidneys due to glomerular filtration, and, in addition, due to tubular secretion. Within twenty-four hours from the moment of use, thirty-two percent of the dosage is excreted by the kidneys in an unchanged form. Eight percent is released as metabolites. Together with bile, approximately thirty percent of the dose taken is secreted.
Is Nolitsin an antibiotic?
As indicated by the instructions for use with tablets, Nolitsin acts as an antibiotic that belongs to the category of second generation fluoroquinolones. Its active component is norfloxacin. The difference between this drug and other fluoroquinolone antibiotics is that it can create significant bactericidal concentrations exclusively in the digestive system and genitourinary tract.
Drug Release Form
The presented drug is produced in the form of tablets, which are coated with a film coating. The antibiotic content in the tablet is 400 milligrams. The original form of the drug is produced in packs of ten, and, in addition, twenty tablets.
Indications for use of the drug
In accordance with the instructions for use, "Nolitsin", as a rule, is prescribed by doctors in the presence of infectious and inflammatory diseases that are caused by pathogens that are sensitive to the main component of this drug. Thus, a medication is prescribed in the following cases:
- The presence of acute and chronic infectious diseases of the urinary tract. Thus, the appointment of this drug is advisable for urethritis, cystitis and pyelonephritis.
- The appearance of genital infections with cervicitis, endometritis and chronic bacterial prostatitis.
- The development of uncomplicated gonorrhea.
- The development of bacterial gastroenteritis, for example, with salmonellosis or shigellosis.
- Carrying out the prevention of relapse of certain infections of the urinary system.
- Sepsis prophylaxis in patients with neutropenia.
- Prevention of diarrhea in travelers.
Contraindications
According to the instructions for use with tablets, "Nolitsin" has a small list of contraindications. This medicine is not suitable for use amid the following factors:
- The presence of glucose phosphate dehydrogenase deficiency in patients.
- Pregnancy in women or breastfeeding.
- Patients in childhood or adolescence up to eighteen years of age.
- The presence of hypersensitivity to norfloxacin and other drugs from the fluoroquinolone category.
This remedy is prescribed with caution in the presence of cerebral arteriosclerosis, with circulatory disorders, and, in addition, against the background of diseases such as epilepsy and renal failure. Its use is not recommended in case of allergic reactions to acetylsalicylic acid.
This is indicated in the instructions for use.
Reviews of "Nolitsin" with cystitis are presented at the end of the article.
Drug dosage
They take the drug inside, it is always done on an empty stomach, not less than an hour before a meal. The medicine is washed down with a sufficient amount of water. The recommended dose is 400 milligrams twice daily. The duration of therapy should be from seven days to two weeks. If necessary, a longer treatment is carried out. This is confirmed by the instructions for use with Nolitsin.
With the development of chronic bacterial prostatitis, 400 milligrams are taken twice a day for six weeks or longer. In the presence of an uncomplicated form of gonorrhea, a single dose of the drug is required in a dose of up to 1200 milligrams or 400 milligrams twice a day for a week. With the development of bacterial gastroenteritis, patients take 400 milligrams twice a day. The course of treatment in this case is five days.
As part of the prevention of diarrhea in travelers, it is advisable to take 400 milligrams a day before the trip. Next, the medicine is taken throughout the trip at 400 milligrams per day, and then a couple of days after its completion. But in this case, it must be emphasized that this medicine should not be consumed for more than twenty-one days.
As part of the prevention of sepsis, the drug is taken at 400 milligrams for eight weeks. In the presence of acute uncomplicated cystitis, it is consumed at 400 milligrams twice a day for five days.
As indicated by the instructions for use, "Nolitsin" with cystitis is also prescribed. For the prevention of recurrent uncomplicated infection of the genitourinary system in case of frequent exacerbations (more than three cases per year), take 200 milligrams once a night. In this case, the course of treatment will be long and will range from six months to several years. Patients with a malfunction in renal activity do not need to adjust the dosage regimen.
Also, according to the instructions for use, "Nolitsin" with pyelonephritis is prescribed twice a day (taking tablets after 12 hours) at 400 mg for up to two weeks. With pronounced positive dynamics and normalization of urine tests, the period of taking the drug is sometimes limited to ten days.
This information is contained in the instructions for use. Reviews "Nolitsin" 400 mg are abundant.
Side effects during use
On the part of the digestive system in patients with the use of “Nolitsin”, a decrease in appetite can be observed along with bitterness in the mouth, nausea, vomiting, abdominal pain, diarrhea and pseudomembranous enterocolitis (which usually occurs during prolonged use). It is possible that an increase in the activity of hepatic transaminases. This is confirmed by the instructions for use and reviews of Nolitsin tablets.
A malfunction of the urinary system is usually accompanied by crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, urethral bleeding, increased urea, and, in addition, blood plasma creatinine. On the part of the nervous system, patients may experience headaches along with dizziness, fainting, insomnia, and hallucinations. In older people, it is possible to accompany well-being with fatigue, drowsiness, anxiety, irritability, a sense of fear, depression and tinnitus.
The work of the heart and blood vessels can be accompanied by tachycardia, arrhythmia, decreased pressure and vasculitis. The skeletal and muscular systems can respond with arthralgia, tendonitis, and tendon rupture. The hematopoietic system reacts with eosinophilia, leukopenia and a decrease in hematocrit. Allergic reactions in the form of a rash, skin itching, urticaria, edema, malignant exudative erythema, and so on are not excluded.
This is also confirmed by the instructions for use and reviews of "Nolitsin."
Drug overdose
Symptoms when an overdose occurs are usually manifested in the form of nausea, vomiting, diarrhea, and in more severe situations dizziness can occur along with drowsiness, the appearance of a cold sweat, seizures and puffy face without changing the basic hemodynamic indications.
The treatment in this situation should certainly be gastric lavage, along with adequate hydration treatment with forced diuresis and symptomatic therapy. In addition, a mandatory examination of the patient and observation in a hospital for several days is required. There is no specific antidote to this drug.
What else does the instructions for use with Nolitsin 400 mg tell us?
Drug interaction
Against the background of the simultaneous use of norfloxacin with theophylline, the concentration of the latter in the blood plasma should be monitored. In addition, a dose adjustment is necessary, since norfloxacin can reduce theophylline clearance by twenty-five percent. In this regard, the corresponding undesirable side effects may develop. The main component of the drug - norfloxacin can also reduce the effect of nitrofurans.
The substance norfloxacin enhances the therapeutic effect of drugs such as Cyclosporin and Warfarin. In some situations, when using norfloxacin with these drugs, an increase in creatinine concentration was observed, therefore, such patients need to control this indicator.
The simultaneous use of norfloxacin with antacids that contain aluminum or magnesium hydroxide, as well as the parallel administration of drugs that include iron and zinc, can reduce the absorption of the main component of the drug. The immediate interval between their use should be at least two hours.
The simultaneous use of the drug "Nolitsin" with drugs that lower the seizure threshold, can lead to epileptiform seizures. Concurrent use with glucocorticoids can cause an increased risk of tendonitis, and at the same time cases of rupture of tendons. "Nolicin" is able to enhance the therapeutic effect of hypoglycemic drugs that are derivatives of sulfonylureas.
The concomitant use of "Nolitsin" with drugs that have the potential to reduce pressure can cause a sharp drop in this indicator. In this regard, in such situations, and, in addition, when administered simultaneously with barbiturates and other means for general anesthesia, it is necessary to control the pressure and indicators of the electrocardiogram of the heart.
So it is written in the instructions for use for tablets "Nolitsin" 400 mg.
Alcohol compatibility
Fluoroquinolone antibacterial drugs are categorically incompatible with alcohol. Such a combination can lead to serious consequences and depression of the nervous system. Such conditions can end even with a coma. In addition, given that this drug is excreted mainly by the kidneys, Nolitsin with alcohol, while taking it, can be the cause of severe intoxications associated with a disruption in the process of utilization of metabolic products.
In patients with kidney disease and problems with the nervous system, combining this medication with alcohol also increases the risk of seizures. It should be noted that drinking alcohol completely eliminates the effectiveness of this antibiotic. In this regard, such a combination can be dangerous not only with side effects, but also with the factor that makes antibiotic treatment completely useless.
Against the background of sharing with alcohol, further progression of the main infectious disease along with the development of purulent complications is likely. The combination of Nolicin with alcohol can also lead to toxic hepatitis and an increased risk of pseudomembranous colitis.
special instructions
During the treatment with Nolitsin, patients are required to receive a sufficient amount of water. During therapy, an increase in prothrombin value is possible. As part of surgical interventions, monitoring the state of the blood coagulation system is important. Against the background of treatment with this drug, patients should avoid exposure to direct sunlight.
In case of pain in the tendons or in the presence of the first signs of tenosynovitis, it is recommended to cancel the drug. In addition, during the treatment period, it is recommended to avoid heavy physical exertion. Care should also be taken when driving.
This is described in the instructions for use.
Analogs of "Nolitsin"
This medicine has structural analogs in the form of medicines such as Glurenorm along with Normax, Deprenorm, Norilet, Norfacin, Monural, Sofazin, Noroxin, Chibroxin and Renor. .
What is better "Nolitsin" or "Monural"?
It is impossible to unequivocally answer this question. Before choosing a medicine for the treatment of cystitis, it is necessary, first of all, to take into account many different factors, for example, such as the age of the patient, the presence of certain contraindications, the frequency of relapses, the presence of sensitivity and complications.
Usually the main drug of choice of specialists in the treatment of uncomplicated cystitis is Monural. This medicine is unique in its kind, since the therapeutic course is a maximum of two days. "Monural" is easily tolerated by patients, with almost no side effects during and after treatment.
In addition, Monural can be used to treat children from the age of five; it is also suitable for pregnant women. The immediate advantage of Nolitsin is that it can be used for long courses in order to prevent exacerbations.
Instructions for use with Nolitsin 400 mg confirms this.
Reviews about the drug
Among the reviews of "Nolitsin" there are a variety of comments. In positive, high efficacy of the drug is noted. People write that thanks to its use, improvement in well-being occurs only a day after the start of therapy. Many buyers also note the relatively low price of the drug as an advantage, which is especially important if a long course of treatment is necessary.
Negative reviews mainly relate to the common side effects of the drug, especially on the part of the digestive organs and nervous system. Some don't like the overly large size of the pills. People also write that this drug causes bitterness in the mouth. And, finally, it discourages patients from using this medicine that Nolitsin is an antibiotic, which means that it leads to undesirable consequences associated with a violation of the intestinal microflora.
We reviewed the instructions for use and reviews of "Nolitsin" 400 mg.