With microorganisms that are dangerous to humans, people have been fighting for a very long time. Many different drugs have been developed. Among them there is such a drug as "Fazizhin." This is an antiprotozoal drug with antibacterial activity. To take the drug, there are many nuances, so before starting treatment, you must definitely study the instructions for use.
Release form and composition of the drug
The drug is available in the form of coated tablets. It goes on sale in boxes. 1 pack includes 1 blister with 4 tablets and instructions for use "Fazizhina".
The main active ingredient in the drug is tinidazole. Auxiliary components:
- corn starch;
- titanium dioxide;
- propylene glycol;
- sodium lauryl sulfate;
- hypromellose;
- alginic acid;
- magnesium stearate;
- microcrystalline cellulose.
pharmachologic effect
Tinidazole in Fazizhine is an antiprotozoal substance with antibacterial effect. This component of the drug effectively copes with the following pathogens:
- Trichomonas vaginalis - vaginal trichomonas, a unicellular microorganism. The causative agent lives in the genitourinary organs. Only in them the living conditions are favorable for Trichomonas.
- Entamoeba histolytica is a dysenteric amoeba. This is a type of parasitic protozoa.
- Lamblia intestinalis - intestinal lamblia.
- Bacteroides spp. - bacteroids. Genus of gram-negative anaerobic rod-shaped bacteria belonging to the family Bacteroidaceae.
- Clostridium spp. - clostridia, belonging to the genus of gram-positive, obligate anaerobic bacteria. These microorganisms are representatives of the normal microflora of the digestive tract, female genital tract. Under certain conditions, clostridia can acquire pathogenic properties and provoke the development of diseases.
- Eubacterium spp. - eubacteria. They are part of the normal microflora of the human intestine.
- Fusobacterium spp. - fusobacteria. Gram-negative anaerobic polymorphic microorganisms.
- Peptococcus spp. - peptococci. Gram-positive anaerobic cocci, which in their morphology are similar to staphylococci.
- Peptostreptococcus spp. - peptostreptococcus. From the name it can be understood that these microorganisms are morphologically similar to streptococci.
- Veillonella spp. - veylonella. Genus of gram-negative anaerobic cocciform non-spore bacteria. They are present in the normal microflora of the human body. However, some species can cause purulent and wound infections.
The instructions "Fazizhina" noted that tinidazole penetrates into the pathogens. The substance, being in microorganisms, inhibits the synthesis and damages the structure of DNA. As a result of this influence, pathogens die.
Pharmacokinetics
The active substance of the drug is characterized by a high degree of absorption, 100% bioavailability. After taking 2 g of the drug, the maximum concentration of tinidazole is reached after 2 hours. Its value is 40–51 μg / ml. For a period of 72 hours, the level of active substance drops to 1 μg / ml.
When treating with Fazizhin, it is important for patients to know that tinidazole from the composition of the drug crosses the placental barrier and the blood-brain barrier.
The instructions "Fazizhina" said that the metabolism of the drug occurs in the liver. During this process, pharmacologically active hydroxylated derivatives are formed. The elimination half-life is 12-14 hours. The medicine is excreted with bile (50%), through the kidneys (12% in the form of metabolites and 25% unchanged).
Indications for use
"Fazizhin" is prescribed by doctors when they identify protozoal and anaerobic infections in their patients. Also, the drug is used for preventive purposes. The active substance prevents the occurrence of postoperative anaerobic infections.
Under what conditions is the medicine effective? Here is a list of the evidence Fazizhina has:
- peritonitis - a serious condition caused by inflammation of the visceral and parietal peritoneum;
- bacterial septicemia - a type of sepsis, which is characterized by the presence of purulent neoplasms on the heart valves;
- abscess - purulent inflammation of tissues;
- endometritis - an inflammatory process in the uterus, covering the surface layer of the endometrium;
- endomyometritis - an inflammatory process that affects the muscle and mucous membranes of the uterus;
- tubo-ovarian abscess - purulent disease of the uterus;
- nonspecific vaginitis - inflammation that occurs in the mucous membranes of the vagina due to the activation of conditionally pathogenic microflora;
- trichomoniasis - a sexually transmitted disease that occurs due to vaginal trichomonas;
- empyema - a pathological condition characterized by the accumulation of purulent masses in the natural cavity of the body or inside a hollow organ;
- giardiasis - a disease provoked by giardia (they parasitize in the small intestine);
- amoebiasis - a disease caused by a pathogen such as Entamoeba histolytica;
- infections of soft tissues and skin;
- postoperative wound infection.
Contraindications
At "Fazizhina" in the instructions for use, several contraindications are indicated. This medicine should not be used if there is such an individual characteristic of the body as hypersensitivity to tinidazole and other 5-nitroimidazole derivatives. Among the contraindications are pathological conditions - a violation of the processes of formation, maturation and development of blood cells, organic diseases of the central nervous system. It is also forbidden to be treated with "Fazizhin" during the first trimester of pregnancy and during breastfeeding.
Explanations for taking the drug during pregnancy and lactation
In the first trimester of pregnancy, as already mentioned above, the drug is prohibited. It can negatively affect the fetus. In the II and III trimester, Fazizhina tablets are sometimes prescribed, but this happens only in cases where the expected benefit from the use is higher than the potential risk.
During lactation, a medicine can also be used. The doctor, when prescribing "Fazizhina", must inform the nursing woman about the need to stop breastfeeding for the period of treatment. After the end of therapy, you can resume feeding, but not immediately. Studies have shown that tinidazole is stored in breast milk for 72 hours after taking the drug.
Recommended Dosage
The instructions for use "Fazizhina" indicates that the dosage is determined individually for each patient. The dose can be from 1.5 to 2 g. This amount of medication is indicated for adults. The dose is taken 1 time per day.
The duration of treatment is also set for each individual patient. When making a decision, the doctor takes into account the diagnosis and those changes that have occurred due to therapy in the patient's body. Practice shows that the drug is prescribed for 1-10 days. For example, with unspecific vaginitis "Fazizhin" 1-2 days can be used. With intestinal amoebiasis, treatment for adults is prescribed for 2-3 days. With inefficiency, therapy is extended to 6 days.
Use in childhood
For children who are less than 12 years old, specialists do not prescribe Fazizhin. There is no evidence confirming the 100% safety and effectiveness of the use of this drug for the treatment and prevention of protozoal and anaerobic infections.
For children over 12 years old, doctors prescribe from 50 to 60 mg of the drug per 1 kg of weight. Multiplicity of application - 1 time per day.
Undesirable symptoms
During the application of "Fazizhina" side effects may occur. Sometimes the response to taking the pills appears from the digestive system. Patients complain of:
- nausea
- vomiting
- loss of appetite;
- the disappearance of hunger and weight loss;
- dry mucous membrane lining the oral cavity;
- a sense of metallic taste;
- loose stools.
Allergic reactions are possible. They are manifested by urticaria, rash, itching. There is a chance of angioedema. With this allergic reaction, edema appears on the eyelids, cheeks, lips. An undesirable symptom can affect the lining of the larynx. This is fraught with deterioration, difficulty breathing. Hypercapnic coma may even occur and death may occur.
On the part of the central and peripheral nervous systems, symptoms such as dizziness, headache, fatigue, impaired pronunciation, impaired coordination of movements, peripheral neuropathy are observed. In rare cases, cramps occur due to medication.
special instructions
The instructions for the use of tablets "Fazizhina" contains a number of special instructions. When treating with this medication, you need to refuse to drive a car and work that requires increased attention and a quick response. The fact is that there is a likelihood of side effects such as dizziness, impaired coordination. A person engaging in potentially hazardous activities may be in a situation in which his health will be harmed.
A special indication is established for the diagnosis of trichomoniasis. This disease is sexually transmitted, so both partners should be treated, and not one of them. It is also important to consider the following:
- during therapy should not drink alcoholic beverages;
- when undesirable effects from the central nervous system appear, drug treatment should be discontinued;
- if tablets are used for more than 6 days, then regular monitoring of the peripheral blood picture is necessary.
Drug interaction
The instructions for use "Fazizhina" do not write any warnings about the simultaneous use of this medication and other medicines. The manufacturer only notes that tinidazole from the composition of the drug is incompatible with alcohol. When taking pills and alcohol-containing drinks, an alcohol-antabuse-like reaction may develop. It is characterized by an increase in heart rate and the occurrence of colicky pains in the abdomen, hot flashes, and vomiting.
Reviews about "Fazizhine"
People who used Fazizhin had different opinions. In positive reviews, patients indicated that the medication helped them cope with detected protozoal and anaerobic infections or prevent the development of postoperative complications. From negative reviews, you can find out that not all patients had smooth treatment. Some people have experienced side effects.
Analogs
"Tinidazole" - a drug that is an analogue of "Fazizhina." It belongs to the group of antiprotozoal agents with antibacterial action. The active substance from the composition has the same name as the medication itself. Tinidazole is prescribed for trichomoniasis, giardiasis, amoebiasis, infections caused by anaerobic bacteria, mixed aerobic-anaerobic infections (in combination with antibiotics), the presence of Helicobacter pylori in the body (as part of combination therapy). The drug is also used for prophylactic purposes after operations, when the likelihood of developing complications - anaerobic infections increases.
Among the analogues include "Tsifran ST" - a combined drug with antiprotozoal and antibacterial action. The composition of the medication contains 2 active substances - tinidazole and ciprofloxacin. “Tsifran ST” is able to prevent postoperative infectious complications, as well as eliminate a number of diseases. Here are some indications for using this medication:
- endometritis, salpingitis, bacterial vaginosis;
- amoebiasis, dysentery, bacterial diarrhea;
- infections of the genitals provoked by vaginal trichomonas;
- lung abscess, aspiration pneumonia, pleural empyema, infectious pleurisy;
- sepsis and others
"Tinidazole" is not used for individual intolerance to components, hematopoiesis, in children under 12 years old, in the first trimester of pregnancy, with organic diseases of the central nervous system. “Tsifran ST” has such contraindications as hypersensitivity to the substances included in the pregnancy, lactation, age up to 18 years, epilepsy, simultaneous treatment with tizanidine.
When prescribing "Fazizhina" or its analogues, patients must strictly follow all the recommendations of the attending physician. When medicines are used correctly, the result of therapy is positive, expected.