The drug "Ambrobene" is considered a drug that belongs to the pharmacological group of expectorant medicines and is used for cough syndrome of any origin to improve the excretion of pathological secretions. The active substance of this medicine is ambroxol.
Structure
"Ambrobene" is made in the form of tablets, which are packaged in blisters of ten pieces, in one package contains twenty capsules. They are white in color, small in size, have a biconvex shape, on the one hand there is a risk. There is no dividing strip on the back, and it is smooth. The active substance that is part of the drug, Ambroxol hydrochloride, is a mucolytic agent. In addition, in the structure of the tablets there are additional substances, which include:
- lactose monohydrate;
- corn starch;
- stearic acid;
- colloidal silicon dioxide.
Pharmacological properties
The main active ingredient of the Ambrobene drug in tablets, Ambroxol, belongs to the group of mucolytics. This is due to his main actions, which include:
- Mucolytic effect - an active microelement activates the production of enzymes by cells of the inner lining of the bronchi, which disrupt the connection between the components of mucopolysaccharide molecules of pathological secretion, which leads to its dissolution and simplification of excretion from the respiratory tract. In addition, sputum liquefaction is carried out by increasing the action of secretory cells with ambroxol, producing a more fluid pathological secret.
- Secretomotor effect - the main component of the Ambrobene preparation increases the motor activity of the cilia, which cover the surface of the mucous membrane of the bronchi and trachea, due to which sputum production increases.
Due to the increased excretion of pathological secretion, a mucolytic effect of the active substance, Ambroxol, arises, the cough becomes wetter, and its intensity decreases.
In addition, an important effect of the drug is the elimination of viruses or other pathological factors from the bronchi together with sputum:
- dust;
- aggressive chemical compounds.
After using the tablet, its basic substance reaches its maximum pharmacological content in about twenty or thirty minutes. Ambroxol metabolism occurs in the liver, where up to ninety percent of the active trace element is modified.
Metabolism is excreted by the kidneys with urine. The elimination half-life is on average from eight to twelve hours. Accordingly, during this period, the therapeutic concentration of the active ingredient, which is necessary for the implementation of its therapeutic actions, predominates in the body. Ambroxol is able to penetrate into breast milk during lactation, as well as into the fetal tissue through the placenta in an interesting position.
Indications
The main indications for the use of the drug in tablets include damage to the respiratory tract, accompanied by an inflammatory process of the mucous membrane, cough syndrome and the formation of a thick pathological secret. Such diseases, as a rule, include:
- Infectious bronchitis (a common inflammatory disease affecting the lower respiratory tract).
- Bronchial asthma (a serious disease of the respiratory system with a chronic course, in which there are attacks of dry cough with shortness of breath and suffocation).
- Pneumonia (infectious pneumonia affecting the alveoli or other lung tissue).
- The inflammatory process of the mucous cavity of the trachea, manifested by edema, excessive production of pathogenic secretion.
- The diffuse inflammatory process of the bronchial mucosa of any etiology, which is caused by various toxic effects, primarily smoking.
- A disease characterized by irreversible changes, expansion, deformation of the bronchi.
- A complex congenital disease, which is manifested by tissue damage and the destruction of the secretory activity of the endocrine glands.
Since Ambroxol actively stimulates the excretion of mucus, when taking it, it is necessary not to take measures and not to use drugs that inhibit the cough syndrome, as this can lead to even greater sputum formation in the branches of the respiratory throat.
Contraindications
There are several pathological and physiological conditions of the body in which the use of "Ambrobene" is prohibited:
- Individual intolerance to the substances that make up the drug.
- Pathology of the mucous membrane of the stomach and intestines.
- Duodenal ulcer (a chronic disease of a recurring nature, the manifestations of which are the formation of an ulcer).
- Inflammation of the mucous membrane of the gastrointestinal tract with the formation of erosions of various sizes on its surface.
- The first three months of pregnancy.
Regarding the intake of Ambrobene in the following months of pregnancy, there is no exact information about its harmful effects on the growing fetus. Therefore, the doctor has the right to prescribe a medicine only if the expected positive effect for the expectant mother is higher than the probable danger to the fetus.
Cough tablets "Ambrobene": instructions for use
The drug contains ambroxol, in one tablet - thirty milligrams of the active substance. When taken orally, the active trace element is absorbed into the blood from the small intestine and accumulates in the respiratory system, where it exerts a therapeutic effect.
The dosage of the drug is selected depending on the severity of dry cough and the age of the patient, according to the instructions for Ambrobene tablets:
- Children from two to six years old are recommended to take one second tablet twice a day. The maximum daily dose is from thirty to forty-five milligrams. After 6 years - half a tablet 3 times a day.
- Adolescents over twelve years of age and adult patients are prescribed one tablet two to three times a day in the first two to three days from the onset of the disease. Initially, the maximum daily dosage varies from sixty to ninety milligrams. In the following days, maintenance dosage is used, which is equal to one tablet twice a day, that is, 60 milligrams per day.
According to the instructions for the use of Ambrobene tablets for adult patients, if necessary, the dose can be increased to four tablets per day. In this case, the maximum daily dosage will be one hundred twenty milligrams.
The tablet must be taken as a whole, without chewing, while drinking plenty of water. For preventive purposes, in order to prevent the negative effect of the active substance on the mucous membrane of the stomach and duodenum, the drug is recommended to be used after eating.
Side effects
According to the reviews and instructions for use, Ambrobene tablets (30 mg) are well tolerated when taken orally. Some patients may experience negative reactions, which include:
- Allergy to an active trace element or additional components.
- The appearance of a rash on the skin.
- Hives.
- Angioneurotic edema of the surface of the skin and subcutaneous tissue of the face or genitals (Quincke's edema).
- Anaphylaxis (acute pathological condition that occurs with repeated penetration of the allergen).
- Deterioration of the general condition of a person after taking the drug.
- Migraine.
- Fever.
- Digestive disorders.
- Bloating.
- Spastic pain.
- Dry mucous membranes.
If one of the signs occurs, which indicates the development of an undesirable reaction from the use of the medication, its reception must be stopped and consult a doctor.
Features
Before use, it is important to carefully read the instructions for the Ambrobene tablets (30 mg). It is necessary to pay attention to the features of their reception:
- The use of the drug in the first months of pregnancy is contraindicated, since there is no reliable information about the absence of a negative effect of the drug on the fetus.
- In the following months, taking Ambrobene is possible, but only after consulting a treating doctor who individually determines the benefits and harms of both the mother and the child.
- For children under the age of two years, the drug is prescribed only by a medical specialist in a special order.
- Ambrobene tablets are not recommended for use in conjunction with drugs that inhibit cough, as this can lead to stagnation of pathogenic secretions in the respiratory system.
- In diseases of the liver or kidneys, the medication is prescribed with extreme caution, under constant medical supervision.
- The average duration of therapy is approximately four to five days. With longer treatment, it is important to consult a physician.
- The combined use of Ambrobene tablets and antibacterial drugs increases the content of antibiotics in the pathological secretion, due to which the rate of elimination of infection in the respiratory tract increases.
- Admission Ambrobene does not affect the speed of human psychomotor reactions, therefore, its use is allowed for patients whose work requires an increased concentration of attention.
According to reviews and instructions for Ambrobene, tablets can be purchased at any pharmacy without a prescription. If you have any questions regarding their application, you must consult a specialist.
Overdose
With a significant increase in the content of an active trace element in the body, nausea, vomiting, diarrhea can occur. If such signs occur, indicating a possible poisoning with the drug, you need to seek the help of a doctor as soon as possible.
Storage conditions, price
According to the instructions for Ambrobene tablets, the shelf life of the drug is sixty months from the date of their manufacture. Keep the drug out of the reach of children. The price of Ambroben varies from 120 to 350 rubles.
Ambrobene: analogues
There are a number of substitute drugs containing the same active substance - Ambroxol. Among them:
- "Ambrosan."
- "Ambroxol".
- "Lazolvan."
- "Bronchoxol."
- Flavamed.
- Medox.
Flavamed
It is used to reduce the severity of cough of various origins. The drug "Flavamed" is made in the form of tablets and syrup. The main active ingredient is ambroxol hydrochloride. The active substance is instantly and completely absorbed into the bloodstream, evenly distributed in the tissues, and also enters the structure of the respiratory system. The cost of the drug is 130–230 rubles.