In Russia, under the name Miramistin, 2 drugs were registered - a solution for local use (manufacturer - the Russian company Infamed) and an ointment for local and external use (manufacturer - the Ukrainian pharmaceutical company Darnitsa). The remedy called the latter, some people call the cream. Officially, the drug is not considered a cream, but an ointment. “Miramistin-Darnitsa” is the full trade name of this drug.
Main component
The active substance in the preparation is benzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate (miramistin). This is an antiseptic. This component negatively affects various microorganisms - gram-negative and gram-positive, anaerobic and aerobic, asporogenous and spore-forming microflora. Miramistin acts most strongly on gram-positive bacteria (streptococci, staphylococci, etc.). The active substance also has a negative effect on fungi.
Miramistin improves the effectiveness of antibiotics, because it makes bacteria and fungi less resistant. During the period of application of the ointment, the probability of infection of damaged areas of the skin is reduced, regenerative processes are accelerated. Tissues that have undergone necrosis, miramistin dehydrates. Thanks to this, a dry scab is formed faster.
Excipients
Miramistin contains a number of additional components. It:
- purified water;
- macrogol 6000;
- macrogol 1500;
- macrogol 400;
- disodium edetate dihydrate;
- propylene glycol;
- poloxamer 268.
Indications for use
Ointment (cream) "Miramistin" is used in various fields of medicine:
- In traumatology, surgery. With the help of the drug they treat various damaged areas of the skin where the infection has got — trophic ulcers, pressure sores, festering postoperative wounds, etc. Miramistin is also suitable for the prevention of reinfection of granulating wounds.
- In dermatology. Miramistin helps treat skin diseases - candidiasis of the mucous membranes and skin, strepto-, staphyloderma, large fold dermatomycosis, smooth skin and feet, keratomycosis.
- In combustiology. "Miramistin" can be prescribed as a remedy for frostbite, burns of II and III A degrees. Another indication for use is the preparation of burn injuries for dermatoplasty.
Miramistin is dispensed without a prescription, so it is recommended that everyone add this drug to their home medicine cabinet. Ointment can be used without a doctor’s prescription when receiving minor injuries at home or at work. In such cases, Miramistin performs a preventive task - it reduces the risk of wound infection complications.
Contraindications
Do not use Miramistin ointment (cream) with individual sensitivity to the components of the drug. This contraindication is indicated in the instructions. When ignored, people are faced with allergic reactions.
The instructions do not indicate indications for the use of Miramistin for children. The thing is that the manufacturer advises using the drug only for adults, with the exception of pregnant and lactating women. The reason - there is not enough experience with the use of ointments for the treatment of children, women during pregnancy and lactation. Specialists cannot say that “Miramistin” is absolutely safe for the mentioned groups of patients, because during the period of use of the drug, the active substance can’t get into the systemic circulation.
How to apply
Before starting treatment with ointment, standard treatment of an existing wound or burn is performed. After that, they use Miramistin. The cream is used in several ways:
- A sufficient amount of the medicine is applied directly to the affected area. Next, to prevent infection, a sterile gauze dressing is applied.
- A small amount of the drug is applied to the dressing. Next, this processed dressing is applied to an injured place, a wound.
- The drug is impregnated with tampons. Then, swabs loosely fill the wound cavity after surgical treatment.
- If the patient has fistulous passages, then gauze turundas with Miramistin are introduced into them.
The frequency of use of the drug depends on the problem. If there are wounds and burns in the 1st phase of the wound healing process, then Miramistin is used once a day. In the 2nd phase, the medicine is used 1 time in 1-3 days. The duration of treatment is determined by the dynamics of healing and cleansing of damaged areas of the skin.
With dermatological diseases, the drug is applied to the affected areas several times a day. If a gauze dressing soaked with medication is used, then it is applied 1-2 times a day. The duration of treatment can be 5-6 weeks.
Side effects and overdose symptoms
The instructions for use of Miramistin ointment indicate that side effects are possible, but you should not pay attention to them. As practice shows, in some patients with trophic ulcers and burns, the drug causes a burning sensation. This side symptom is short-lived. Some time after applying the medicine, it disappears, therefore, when a burning sensation occurs:
- no need to abandon the use of Miramistin;
- no need for analgesics.
To date, experts have not encountered symptoms of an overdose, because the drug is mainly used on small areas of the skin, and the active substance penetrates into the blood in small amounts. But when applying the medicine to a large affected area, a little more miramistin penetrates into the systemic circulation. Possible negative consequences - prolonged bleeding time. With this symptom of an overdose, either the applied dose of the ointment decreases, or the drug is completely canceled. Doctors prescribe menadione sodium bisulfite ("Vikasol"), oral calcium preparations.
Drug interaction
In the instructions for use of the Miramistin ointment, the manufacturer indicated that soap solutions inactivate the drug.
If the infection penetrated deep into the soft tissues, then Miramistin can be used with systemic antibiotics. In this case, the dose of antibiotics can be reduced.
Additional guidance
Miramistin ointment for external use has a wide spectrum of antimicrobial action. Due to this, it can be started to be used before the identification of the pathogen of the infectious process. Ointment negatively affects not only monocultures, but also mixed bacterial and fungal infections.
The drug "Miramistin-Darnitsa" effectiveness is enhanced if it is applied to a wound previously prepared, washed with an antiseptic solution.
Reviews about ointment
Many reviews were left about the Miramistin cream of Ukrainian origin. Almost all of them are positive. The advantages of the drug, people include:
- low price;
- lack of smell;
- lack of pain, tingling after application.
Some people call the ointment a magic wand. Judging from the reviews, it is effective for abrasions, scratches, cuts, wounds. Ointment prevents suppuration, copes with other skin problems.
Analogs
Instead of Miramistin cream, you can use a solution for topical use, which bears a similar name. It contains only 2 components - miramistin and purified water. The solution is recommended for use:
- in the treatment of purulent wounds, purulent-inflammatory processes of the musculoskeletal system and for the prevention of suppuration;
- for the prevention and treatment of suppuration of postpartum injuries, wounds of the vagina and perineum, postpartum infections;
- in the treatment of burns;
- for the prevention and treatment of dermatomycosis, pyoderma, foot mycosis, candidiasis of the mucous membranes and skin;
- for the prevention and treatment of infectious and inflammatory processes occurring in the oral cavity;
- in the complex treatment of diseases such as acute and chronic otitis media, sinusitis, laryngitis, tonsillitis, urethritis.
Those who are looking for the safest remedy should pay attention to Bepanten - an analogue of miramistin for children and adults (for all, without exception). This is an ointment for external use, in which the active substance is dexpanthenol. Indications:
- violation of the integrity of the skin (burns, shallow wounds, abrasions);
- dry skin (this symptom can be eliminated if it is caused by external factors, dermatitis);
- the occurrence of cracks in the nipples during lactation;
- diaper rash and "diaper" dermatitis in children.
The analogues of Miramistin include the balsamic liniment (according to Vishnevsky), which is made on the basis of birch tar and xeroform. The drug has an antiseptic effect, helps to accelerate the regeneration processes. It is recommended to use it in the presence of uninfected, long-term non-healing postoperative, post-traumatic wounds. During pregnancy, liniment can be used only after consulting a doctor. Before the appointment, the specialist assesses the benefits for the expectant mother and the risk to the fetus. The use of the drug during lactation requires the abolition of breastfeeding.
Information on the note: the use of miramistin in veterinary medicine
Miramistin is an effective substance. It is actively used in the treatment of not only people, but also animals. The proof of this is the fact that there is "Alezan" - a cream with miramistin and ASD-2F, ASD-3F. This is a combined antiseptic drug intended for external use. The components of this cream fight against pathogenic microorganisms, contribute to the removal of the inflammatory process, activate the regeneration processes. Alesan was developed for horses with traumatic, postoperative wounds, trophic ulcers, burns, bedsores, fistulas, dermatitis of fungal and bacterial etiology.
In conclusion, it is worth noting that Miramistin-Darnitsa is a truly effective ointment. At the same time, its analogues are no worse. For this reason, you can add any remedy to your home medicine cabinet that is designed to treat wounds, burns and to prevent infection of skin areas. It is especially recommended to buy such a medicine for those people who have children. Every child loves to be active, and often outdoor activities and games lead to injuries and injuries. The treatment for wounds and burns prevents suppuration and accelerates healing.