Today, many patients are prescribed Zoxon. Instructions for use, indications and contraindications, price and availability of analogues are precisely those questions that many people are looking for answers to.
Composition and form of release of the drug
This drug is available in the form of round flat tablets in white (sometimes with a slight yellowish tinge). The main active substance is doxazosin in the form of mesylate. Each tablet contains 1, 2 or 4 mg of this component.
In addition, some auxiliary substances are present, in particular granular microcrystalline cellulose, lactose, colloidal anhydrous silica, magnesium stearate, sodium carboxymethyl starch and sodium lauryl sulfate.
Tablets are packaged in blisters of 10 pieces. In one package can be 3, 9 or 10 of these blisters.
Pharmacological properties
The active component of the drug (doxazosin) is a selective blocker of alpha-1-adrenergic receptors. Such drugs have a positive effect on urodynamics in patients with prostatic hyperplasia. A similar effect is explained by the blockade of alpha-1-adrenergic receptors, which are located in the tissues of the bladder neck, as well as the capsule and stroma of the prostate gland itself.
In addition, the drug leads to a decrease in blood pressure, as it reduces the total peripheral vascular resistance. Also, this tool has a positive effect on the level of lipids in the blood, as it significantly reduces the concentration of cholesterol and triglycerides. Thus, the medicine also prevents the development of coronary heart disease. "Zoxon" leads to a decrease in the degree of left ventricular hypertrophy, inhibits platelet aggregation and reduces the likelihood of blood clots. However, the drug does not have any negative effect on metabolic processes.
After administration, the tablet dissolves rather quickly and is absorbed by the walls of the digestive tract. The maximum concentration of doxazosin in the blood is observed 1-2 hours after administration. The active component binds to plasma proteins by approximately 98%. The half-life is 22 hours. Metabolites are excreted primarily with feces.
Indications for use
Many readers are interested in the question of in which cases it is advisable to take the drug "Zoxon". Tablets are most often prescribed to patients suffering from benign prostatic hyperplasia (prostate adenomas). In particular, the medicine helps to eliminate urination disorders caused by squeezing the bladder and urinary tract (imperative urges, feeling not completely empty of the urinary bladder, frequent nightly urges, etc.).
In addition, arterial hypertension (increase in blood pressure) is also an indication for use. By the way, if the patient suffers from both hyperplasia and hypertension, tablets act immediately in both directions. Under normal pressure, taking the drug does not cause changes.
The drug "Zoxon": instructions for use
It is immediately worth noting that only a specialist can prescribe such a medicine. The doctor knows how to take Zoxon tablets correctly. The instruction for use states that the dosage depends on the problem that is found in the patient and the general condition of his body.
For example, with prostate adenoma, as a rule, the daily norm is 2-4 mg (1-2 tablets). The drug should be taken once a day, without chewing, but be sure to drink plenty of water. The maximum daily dose is 8 mg.
The treatment regimen for hypertension looks completely different. As a rule, at first 1-2 mg of the active ingredient is prescribed to the patient. At the first admission, it is advisable to put the patient to bed, since the first dose of the medicine can cause some side effects - this is completely normal. Then the amount of the drug is gradually increased to achieve the maximum therapeutic effect - in most cases, patients require a dose of 8 mg. The maximum daily amount, which in no case can be exceeded, is 16 mg.
The duration of therapy is determined by the attending physician, but the tablets are suitable for long-term use. In most cases, treatment lasts about a month, after which you need to take a break. During therapy, you can not drive a car, as well as drink alcoholic beverages.
Contraindications to therapy
Of course, the important question is whether all categories of patients can take Zoxon. The instruction says that this drug still has some contraindications.
To begin with, we note that the drug should not be taken in patients with hypersensitivity to doxazosin, quinazoline-derived substances, as well as other components of the tablets. Also, the drug is not used to treat children and adolescents under the age of 18.
Relative contraindications include pregnancy and lactation. The results of the studies show that the drug does not have embryogenic or teratogenic effects. Nevertheless, its effect on the fetus is not fully understood. The medicine can be taken only if the benefits to the mother's body outweigh the possible risk to the growing child.
The medicine “Zoxon” is used very carefully for the treatment of patients suffering from orthostatic hypotension, aortic or mitral stenosis, as well as various liver disorders.
Side effects and possible complications
Can taking Zoxon tablets cause any complications? Instructions for use indicate that some adverse reactions are possible, and they depend on the problems present in the patient. For example, in people suffering from high blood pressure, the first dose of the drug can cause orthostatic hypotension. Side effects can also include dizziness, asthenia, increased fatigue, headaches, swelling, constant drowsiness, and nausea.
In patients with benign hyperplasia, all of the above symptoms may also occur. In addition, some men complain of irritability, priapism, and dry mouth. Sometimes therapy can lead to the development of gynecomastia, increased activity of liver enzymes, jaundice. Alopecia, various disorders of the kidneys, as well as arthralgia, muscle weakness, cramps, blurred vision, tinnitus, shortness of breath, cough, bronchospasm are rarely observed. With increased sensitivity to the components of the drug, an allergic reaction may occur, which is accompanied by a skin rash, redness, itching and swelling.
It is extremely rare that medication causes such serious complications as angina pectoris, myocardial infarction, and cerebrovascular accident.
Overdose and its main symptoms
Many patients are interested in the question of whether an overdose of Zoxon is possible. The instruction indicates that such cases are indeed recorded. Taking too much dose of the drug leads to a sharp decrease in blood pressure, which is sometimes accompanied by loss of consciousness.
In such cases, the patient must be laid on his back, raising his legs and lowering his head down, and then call the ambulance. As a rule, gastric lavage is first done, after which the patient is prescribed activated charcoal or other sorbents. In the future, symptomatic therapy is performed.
The drug "Zoxon": analogues and substitutes
For one reason or another, this drug is not suitable for every patient. And in such cases, the first question is whether it is possible to replace the drug “Zoxon” with something.
Analogues of the drug, of course, exist. For example, medications such as Prostamed, Vitaprost and Prostasabal are widely used to normalize the outflow of urine in medicine. But the drug "Finast" not only eliminates problems with urination, but also helps to reduce the size of the prostate gland. Analogues include such medicines as Kardura, Proscar, Penester, Adenostop, Speman Forte and many others. Some drugs are cheaper, while the price of other drugs is much higher. In any case, you can not pick up an analogue on your own - this can only be done by the attending physician.
How much is the medicine?
Of course, the issue of cost is important for every patient. So how much will the Zoxon tablets cost? The price, of course, will depend on many factors. In particular, it is worth taking into account the manufacturing company, the city of residence, the financial policy of the pharmacy, etc.
On average, 30 tablets with a dosage of 1 mg will cost you 210-270 rubles. At the same time, the same package of thirty tablets, but with a dose of 2 mg of active substance, costs about 320-400 rubles. By the way, in most cases, one pack is enough for a whole course of treatment.
Reviews of patients and doctors
Of course, many patients are interested in the question of what experts and patients really think about the Zoxon drug. Reviews of doctors are positive - the medicine really copes with its main task, normalizing urination in various diseases of the prostate gland. Moreover, pills help maintain blood pressure, which is very important, given the fact that older people are most likely to suffer from prostate diseases.
Patients also leave positive feedback. According to them, the effect of the pills appears a few days after the start of therapy. The drug really improves the quality of life of sick men. It is also convenient that the medicine should be taken only once a day. And its cost is quite affordable, which is also an indisputable advantage.