Nonsteroidal anti-inflammatory drugs are sold in all pharmacies. However, not every patient is allowed to use such painkillers. This is due primarily to the fact that they have a large number of side effects.
Today we will tell you about what a medicine like Artoxan is. Instructions for use of this tool will be discussed later. Also from this article you will find out the cost of this drug, its contraindications and side effects.
Composition, form, description and packaging
The drug "Artoxan" goes on sale in the form of a lyophilized powder of green-yellow color. The carton pack also contains a solvent in the form of a colorless and clear liquid.
The active element of this tool is tenoxicam. In addition to it, the composition includes the following excipients: sodium hydroxide, mannitol, disodium edetate, ascorbic acid, hydrochloric acid and tromethamine.
The drug goes on sale in bottles (solvent - in ampoules) and cardboard packaging, respectively.
Drug action
What is a medicine like Artoxan? Instructions for use indicate that it is an effective non-steroidal anti-inflammatory drug that has a strong analgesic and slightly less pronounced antipyretic effect.
The properties of this medication are due to the inhibition of two isoforms of the cyclooxygenase enzyme. As a result of this effect, the metabolism of arachidonic acid is disrupted and the synthesis of prostaglandins is blocked.
The anti-inflammatory properties of this drug are due to a decrease in capillary permeability, inhibition of the synthesis of inflammatory mediators (histamine, prostaglandins, lymphokines, bradykinin and complement factors), as well as stabilization of lysosomal membranes.
Also, the use of the drug in question reduces the number of free radicals in the inflammatory focus, inhibits phagocytosis and chemotaxis, slows down the proliferative phase of inflammation, has a chondroprotective effect and reduces post-inflammatory tissue sclerosis.
It should be noted that the medication "Artoxan", the analogues of which are presented below, reduces pain in the inflamed area and affects the thalamic centers of pain. Also, with prolonged use, it has a desensitizing effect.
With rheumatic diseases, this medication relieves pain in the joints, reduces their morning stiffness and swelling. In addition, it improves functions and increases the number of movements of the ligamentous apparatus.
Drug kinetics
The medication "Artoxan" (injections) has a long half-life (about 60-75 hours). It passes fairly easily through the histohematological barriers, and also penetrates well into the synovial fluid.
This tool is characterized by high bioavailability (almost 100%).
Indications
What diseases does the drug “Artoxan” treat? Instructions for use indicate the following indications:
- rheumatoid arthritis, ankylosing spondylitis and gouty arthritis;
- inflammatory and degenerative diseases of the musculoskeletal system, accompanied by severe pain syndrome;
- osteoarthrosis and osteochondrosis;
- non-specific polyarthritis of an infectious nature;
- bursitis, tendonitis, myositis and periarthritis;
- neuralgia, arthralgia, ischalgia, myalgia and lumbago;
- burns and injuries.
Contraindications
Medication "Artoxan", reviews of which are more positive, is contraindicated in:
- gastrointestinal bleeding;
- hypersensitivity to tenoxicam, as well as other NSAIDs;
- erosive and ulcerative lesions of the digestive tract;
- pregnancy
- "Aspirin triad";
- breastfeeding;
- in childhood;
- renal failure;
- severe impaired renal and hepatic function;
- heart failure;
- blood diseases.
The drug "Artoxan": instructions for use
How should we use the drug in question? According to the instructions, this medication is intended for intravenous or intramuscular administration. As a rule, it is prescribed in a dosage of 20 mg once a day. As a maintenance dose, 10 mg of the drug per day is used.
With severe pain, the amount of the drug used can be increased to 40 mg once a day.
In the presence of acute attacks of gouty arthritis, the medication is prescribed 20 mg twice a day for the first three days, and then 20 mg once for five days.
Side effects
What are the undesirable effects associated with the use of the medication "Artoxan"? The injections considered by us can cause:
- on the part of the National Assembly: headaches and dizziness;
- from the gastrointestinal tract: nausea, discomfort and pain in the abdomen, flatulence;
- allergies: urticaria, itching, erythema, Lyell and Stevens-Johnson syndrome.
Also, the use of this agent can change laboratory parameters (an increase in the concentration of urea and creatinine in the blood, as well as an increase in the activity of liver transaminases).
Drug interaction
Taking the drug in question enhances the effects of lithium preparations, as well as indirect anticoagulants. In this regard, the prothrombin index of the patient should be monitored.
When using this medication with diuretics, it is necessary to take into account the probable delay of sodium and water in the patient's body.
Special recommendations
In the process of prolonged use of "Artoxan" it is necessary to control the liver and kidney function of the patient.
With surgical interventions, it should be borne in mind that this medication can increase bleeding time.
With extreme caution, this drug is prescribed to persons under 18 years of age due to a lack of sufficient information about their use of tenoxicam.
The drug "Artoxan": price and analogues
The following drugs are analogues of the medication in question: Oxytene, Ketorolac, Aspicard, Ketoprofen, acetylsalicylic acid, Indomethacin, Diclofenac sodium.
The price of this drug is not very high. It is 60-80 rubles.
Drug Reviews
As mentioned above, NSAIDs are very popular among people suffering from diseases of the musculoskeletal system. "Artoxan" is the most effective drug. It quickly eliminates pain, relieves swelling and swelling.
Like any non-steroidal drugs, this medication very often contributes to the appearance of adverse reactions, especially from the digestive tract. Therefore, such a medicine should be used only for special indications.