The medicine “Ursosan” is produced in the form of capsules, each of which contains 250 mg of the active substance of ursodeoxycholic acid. The drug is included in the clinical-pharmacological group of hepatoprotectors with choleretic, dissolving gallstones action.
Ursodeoxycholic acid is additionally characterized as a pharmaceutical agent with hypolipidemic, hypocholesterolemic and some immunomodulatory effects.
The drug "Ursosan", instructions for use indicate polar properties, which allows the formation of non-toxic mixed micelles. Thus, it is possible to reduce the ability of gastric reflux to destroy cell membranes with such diagnoses as peptic gastritis, peptic esophagitis. Ursodeoxycholic acid can create double molecules that make up the membranes of cells such as hepatocytes, cholangiocytes, gastrointestinal epithelial cells, normalize their functions, and increase immunity to cytotoxic micelles.
The use of the drug “Ursosan” allows you to reduce the level of toxic bile acids that damage hepatocytes, stimulate choleresis, affect the successful resolution of intrahepatic cholestasis, and reduce the lithogenic bile index. Therefore, the Ursosan medication, the instructions for use, indicate it is used to dissolve gallstones deposited from cholesterol, to prevent the deposition of new calculi in the bile ducts.
The immunomodulating effect is achieved due to inhibition of the activity of certain antigens, normalization of killer activity of lymphocytes. It has been established that ursodeoxycholic acid stops the development of fibrotic processes in those patients who are diagnosed with primary cirrhosis, alcoholic steatohepatitis, and cystic fibrosis.
Ursosan medicine, application
The drug is prescribed:
- with gallstone disease, proceeding without complications;
- when dissolving gallstones formed from cholesterol in the gallbladder;
- for the prevention of recurrence of calculus after cholecystectomy;
- with chronic hepatitis in an active form;
- with acute hepatitis;
- with toxic liver damage;
- with primary cholangitis;
- with liver diseases associated with alcoholism;
- with steatohepatitis of non-alcoholic origin;
- with primary biliary cirrhosis ;;
- with cystic liver fibrosis ;
- with peptic gastritis and esophagitis;
- with biliary dyspeptic syndrome;
- for the prevention of liver diseases associated with the use of hormonal contraceptives or cytostatics.
The dosage of the drug is chosen by the doctor, depending on the diagnosis and condition of the patient.
The drug "Ursosan", instructions for use, side effects
Disturbances in the digestive system are manifested by nausea, vomiting, diarrhea, constipation, a transient increase in hepatic transaminases; during clinical trials, the formation of calcified gallstones was observed.
Other disorders in the body can be manifested by back pain, allergic reactions, exacerbation of chronic psoriasis, alopecia.
Medication "Ursosan", instructions for use, contraindications
You can not prescribe the drug in the following cases:
- with gallstones containing a lot of calcium;
- with biliary and gastrointestinal fistula;
- with cholecystitis in acute form;
- with liver failure;
- with acute cholangitis;
- with cirrhosis of the liver;
- with renal failure;
- with obstruction of the biliary tract;
- in acute infectious disease of the gallbladder;
- with empyema of the gallbladder ;
- with increased sensitivity to the drug.
When prescribing a drug in order to dissolve gallstones, the doctor must take into account that deposits should be of cholesterol origin, not exceed 15-20 mm in size. At the same time, the gallbladder must function, remain free for more than 50%, in order to maintain patency.