Advances in modern medicine have greatly simplified the selection of drugs for the treatment of inflammatory diseases of the urinary tract. But pathogenic microorganisms have learned to adapt, adapt to various antibiotics and antimicrobials, which must be considered during treatment. The most effective remedy, suitable for long-term treatment, is considered to be “5-NOC”.
Description of the drug
Urological patients are interested in the question: is the drug an antibiotic or not? "5-NOC" - uroantiseptic, an antibacterial synthetic agent of the oxyquinoline group, which neutralizes the pathogen using the active component - nitroxoline. The active substance effectively destroys bacteria and fungi.
Mechanism of action
The healing effect when using "5-NOC" is achieved due to its ability to act on microorganisms that cause inflammation of the urinary tract. When using the product:
- reproduction of DNA cells of microorganisms is impaired, which prevents their reproduction;
- the respiratory function of bacteria is inhibited due to the binding of proteins in cell membranes;
- redox reactions in bacterial cells are disrupted.
Release form and composition
“5-NOC” is an orange-coated tablet containing the antibiotic nitroxoline (50 mg). At the pharmacy shelves, the product comes in bottles packed in cardboard boxes. Each of them has 50 pills.
Indications
For the appointment of “5-NOC”, the indications are acute or chronic inflammatory pathologies of the urinary tract, having an infectious nature:
- pyelonephritis;
- cystitis;
- urethritis;
- infectious diseases of the prostate gland.
In addition, the tool is used to prevent infectious lesions of the genitourinary system after diagnostic measures, such as cystoscopy, surgical procedures, and the introduction of a catheter.
Contraindications
5-NOC tablets are not recommended for use:
- with individual intolerance to the components of the product;
- cataract patients;
- during pregnancy and lactation;
- with pathologies of the liver and kidneys.
According to the instructions, “5-NOC” is also not prescribed for children under 3 years of age.
Side effects
During therapy using the drug, various side effects may occur in the form of:
- pain in the abdomen;
- nausea, vomiting;
- impaired liver function;
- allergic reactions;
- increased blood coagulability;
- neurological disorders;
- malfunctions of the cardiovascular system.
Attention! The bright yellow color of urine after taking the drug should not be alarming, this is a normal reaction of the body.
"5-NOC": instructions for use
Depending on the course of the disease, the state of human health, the duration of treatment, the dosage of the drug is selected. According to the instructions, the drug is taken 4 times a day in the following dosages:
- Adult patients - 100-200 mg of funds for admission. The course of treatment is a month.
- Children from one year to 14 years old - 50-100 mg. The course of treatment is a month.
- Children 2-12 months - 25 mg per 1 kg of body weight. The course of treatment is 1.5-3 weeks.
In order to prevent the drug is used at 100 mg four times a day. 5-NOC tablets are taken with meals without chewing and drinking plenty of water.
Analogs
This tool has been successfully used in the treatment of urinary tract diseases since the 70s, today it is not a drug of choice because of some negative points:
- the acquisition by bacteria of resistance to nitroxoline;
- insufficient concentration of the active substance in the urine;
- the need for high doses of the drug, which leads to the development of side effects;
- long course of treatment.
In this regard, sometimes there is a need to use analogues of "5-NOC", which can be:
- structural, that is, with the same active substance (Nitroxoline, 5-Nitrox, Uroxolin);
- belonging to the same pharmacological group, with a similar mechanism of action (Zivox, Urofosfabol, Monural).
Often patients are interested in which of the drugs is more effective in case of urinary tract pathologies - “5-NOC” or “Kanefron”? What works better? The fact is that these funds do not replace each other, but are often prescribed at the same time, which increases the effectiveness of therapy. "Kanefron" enhances the antibacterial effect of the drug "5-NOC".
Nitroxoline
"Nitroxoline" is an antimicrobial drug that has a detrimental effect on various bacteria, while not having a negative effect on the body. Judging by the reviews, the remedy is very effective in the pathology of the genitourinary organs, since it accumulates in high concentrations in the urine.
This analogue of “5-NOC” has a low cost. The composition has some additional ingredients.
It is not recommended to use the drug for chronic renal failure, accompanied by oliguria (a decrease in the daily amount of urine) or anuria (cessation of urine into the bladder). Do not use Nitroxoline for people with severe liver pathologies, cataracts, neuritis, intolerance to the components of the drug. Contraindicated in pregnant and lactating women.
When taking the drug, nausea and vomiting, rashes on the skin, headaches, tachycardia may occur. During treatment, urine may turn red-yellow.
5 Nitrox
"5-Nitrox" is an imported antimicrobial agent from the low-cost oxyquinoline group. It has a wide spectrum of action. The disadvantage is that the therapeutic effect of the use of this analogue “5-NOC” is not achieved immediately, but for some time.
It is prescribed for pyelonephritis, cystitis, urethritis, epididymitis, as well as for the prevention of infections after surgery.
You can not use the drug for oliguria or anuria, severe liver disease, hypersensitivity to quinolones.
Patient reviews suggest that during treatment, nausea can occur, vomiting and loss of appetite, headaches, paresthesia are possible. Liver function is rarely disturbed. In some cases, rashes appear on the skin, which are accompanied by itching.
Urofosfabol
It is an antibiotic of a group of phosphonic acid derivatives. Available in powder form for the preparation of a solution for intravenous administration. The main active ingredient is fosfomycin.
Prescribe a remedy for acute pyelonephritis, complicated and chronic urinary tract infections. The main contraindication is sensitivity to the active substance. Caution should be exercised by the elderly, patients with allergies, liver diseases, heart and kidney failure.
Fosfomycin is low toxic, therefore, side effects are rare during therapy. In some cases, the following are possible:
- impaired liver function;
- failures in the gastrointestinal tract;
- headaches, cramps (in rare cases);
- cardiopalmus;
- rashes, itching.
The advantage of the drug is a wide spectrum of action, as well as the fact that microorganisms do not develop resistance to it when used with other antibiotics. Of the minuses, patients note low bioavailability and high price.
Uroxolin
"Uroxolin" in addition to nitroxoline contains additional components. Approved for use by children from 3 years. Assign a remedy for acute, chronic urinary tract infections and for the purpose of prevention.
It is not recommended to use the drug for individual intolerance to the components, renal or liver failure. The medicine is not prescribed during pregnancy and lactation.
Some side effects during treatment are possible:
- nausea;
- vomiting
- loss of appetite;
- lethargy, weakness;
- impaired liver function;
- rash.
Zivox
“Zivox” - a modern antibacterial agent, an analogue of “5-NOC”, inhibits the synthesis of proteins in bacteria. Belongs to the class of oxazolidinones. During testing, the drug showed activity against various types of bacteria.
Available in the form of tablets, infusion fluids, granules. The disadvantage is the high cost of the drug.
The drug is contraindicated in the presence of hypersensitivity to its components. With caution is prescribed to pregnant and lactating. When taking the drug in some patients, allergic reactions, abdominal pain, upset stools, nausea, headache, candidiasis, anemia may occur. These occurrences are not a reason for discontinuing therapy.
Monural
The active substance of "Monural" is fosfomycin, which destroys bacteria and prevents their reproduction. For children, the drug is produced in granules, which are allowed to be taken from the age of five.
Indications:
- acute uncomplicated urinary tract infections caused by bacteria sensitive to fosfomycin;
- prophylaxis during operations and diagnostic procedures.
Contraindications:
- severe renal failure;
- hypersensitivity to the components of the drug.
Caution is prescribed for pregnant and lactating. During therapy, you may experience a feeling of nausea, vomiting, diarrhea, heartburn. To eliminate these phenomena, it is necessary to increase fluid intake. Possible development of allergic reactions: rash, itching.
The advantage of this analogue of “5-NOC”, judging by the reviews, is a short course of treatment, the possibility of use with other means. The downside is the high cost.
The drug “5-NOC” has earned quite positive reviews from patients and doctors who note the rapid onset of the desired effect when taking the drug, getting rid of unpleasant symptoms. In addition, when using the drug, side effects rarely occur, in addition, the price of the drug pleases. However, in some cases, for one reason or another, its reception is impossible. In this case, analogues will come to the rescue, the choice of which must be agreed with the attending physician.