The medicine "Prosulpin" application instructions are positioned as a powerful antipsychotic drug that is used in the treatment of various disorders of the nervous system and other diseases. Read more about the above drug.
Brief description of the drug
This medicine belongs to the group of substituted benzamines. In another way, we can say that the drug "Prosulpine" is a typical antipsychotic. Reviews of experts indicate that its action is aimed at blocking dopamine receptors (D2 and D3). Due to this, the above drug produces an antipsychotic therapeutic effect.
50 or 200 mg of sulpiride substance contains one tablet of the drug āProsulpineā.
Side effects when taking this medication, of course, are manifested in some cases. Therefore, the patient during the course of therapy with the above antipsychotic agent should be under the strict supervision of a doctor.
This medicine has several forms. It is available in tablet form, as well as in the form of capsules, solution for intramuscular injection and liquid for oral administration.
The drug should be stored at normal room temperature, but not higher than 25 degrees Celsius. The place should be well protected from light and moisture. About two years is the shelf life of the drug "Prosulpine". Its analogues are not difficult to find. A wide range of substitutes for the aforementioned medicine is presented in the pharmaceutical market.
Pharmacological action of the above therapeutic agent
The medicine "Prosulpine", the photo of which is provided below, is an antipsychotic drug, that is, an antipsychotic. Due to the blocking of dopamine receptors in the tuberoinfudibular region, the sulpiride substance contributes to a significant increase in prolactin levels. It should be noted that in the range of 60-80% the degree of blocking dopamine receptors varies.
The latter are characterized by a fairly high similarity with benzamides, which are characterized by such a feature as a biphasic effect on the neurotransmitter dopamine system. In addition, they block the increase in dopamine synthesis in the synaptic region, that is, they are antagonists of presynaptic D2 D3 auto-receptors.
It should be noted that the above drug is characterized by moderate antipsychotic activity. The latter is combined with the timoanaleptic and stimulating effect of this drug.
The above medicine has the following pharmacological effects:
- antiemetic (dopamine receptors block the trigger zone of the center of vomiting);
- antidepressant;
- antipsychotic.
Sulpiride exhibits an antidepressant effect in doses up to 600 mg. Above this norm, the antipsychotic effect of this drug on the body is already observed.
In addition, the drug "Prosulpine", the instruction indicates this, produces a selective effect on the hypothalamus with symptoms of gastric ulcer and gastroduodenitis. At the same time, high excitation of the centers of the sympathetic nervous system is suppressed, gastric blood supply improves, granulation tissue proliferation is accelerated, mucus secretion processes in the stomach are formed, regenerated epithelium is formed, and capillary proliferation in tissues is improved.
Who is recommended to take this medication?
What are the indications for use of the drug "Prosulpine"? For medicinal purposes, the above medicine is used for such diseases:
- psychosomatic diseases;
- stress ulcers of the digestive tract;
- symptomatic ulcers;
- gastroduodenitis;
- stomach ulcer;
- irritable bowel syndrome (colon);
- drug ulcers;
- ulcerative ulcerative colitis;
- depression of various etymologies;
- neurosis;
- reactive depression;
- dysphoric disorders;
- schizophrenia;
- chronic mental disorders ;
- migraine;
- acute mental disorders;
- dizziness of various etymologies (vestibular neuritis, vertebro-basilar insufficiency, Meniere's disease, otitis media).
The drug "Prosulpine" instructions for use suggest the use for the treatment of disorders of behavioral reactions and psychoses in young patients, that is, in children. These are diseases such as self-mutilation, agitation, stereotype. Also, the medicine "Prosulpin" instructions for use strongly recommends using as part of a course of therapy for childhood autism. This tool is used to treat small patients aged 6 years.
Contraindications to the use of the above medication
The drug "Prosulpine" instruction for use does not recommend use if the patient has signs of the following diseases:
- hypersensitivity to the components of the drug;
- hyperprolactinemia;
- prolactin-dependent tumors (breast cancer, pituitary prolactinomas);
- affective disorders;
- acute poisoning with drinks that contain alcohol;
- aggressive behavior;
- pheochromocytoma;
- acute poisoning with drugs or sleeping pills;
- manic psychosis.
All these conditions are severe contraindications. Also, the medicine "Prosulpine" for use prohibits giving women who breastfeed their children, children under 18 years of age (for 200 mg pills), small patients under 6 years old (for 50 mg pills).
In addition, it should be remembered that with congenital lactose deficiency, glucose-galactose malabsorption, lactose intolerance, it is also undesirable to use the drug āProsulpinā. Contraindications to the use of the above therapeutic agent also apply to pregnant women. Use it for such patients is allowed only if the expected benefit from this medicine will be much higher than the potential risk from it to the fetus.
Side effects
When taking the drug "Prosulpine" (the instructions indicate this), some side effects may occur:
- from the endocrine system - galactorrhea, dysmenorrhea, amenorrhea, frigidity, impotence;
- from the nerves - sedation, tremor, dizziness, early dyskinesia, extrapyramidal syndrome, drowsiness, akinesia with muscle hypertonicity, akathisia, motor excitement;
- increased activity of enzymes (from the side of digestion);
- hemolytic anemia, leukocytosis, aplastic anemia, granulocytosis, thrombocytopenic purpura occur with increasing doses of the drug āProsulpineā (action from the lymph and blood systems);
- tachycardia, orthostatic hypotension, lowering or increasing arterial pressure, lengthening of the QT interval, in some cases the development of such a dangerous disease as torsade des pointes syndrome (from the side of the heart and its system).
Also, other side effects cause the use of this medication. The drug āProsulpineā (instructions, reviews of doctors and patient responses indicate this) can also provoke unpleasant phenomena such as tardive dyskinesia, which is characterized by involuntary rhythmic movements of the face or tongue (with a long therapeutic course of antipsychotics of all groups), hyperthermia. Experts warn that in the latter case, it is especially important to cancel the above remedy in time, since an increase in temperature can be a sign of the development of such a dangerous disease as neuroleptic malignant syndrome.
Weight gain, excessive sweating, skin rash and itching - all these side effects can also cause the drug āProsulpineā. Instructions, reviews of experts recommend in such cases to stop taking the above medications and immediately consult a doctor for medical help and advice.
Use during pregnancy of the above therapeutic agent
The teratogenic effect of the drug was not detected as a result of experiments on animals. Some women who used this medicine during their pregnancy also did not observe the above effect. But these patients took strictly low doses of Prosulpine. Instructions for use, expert reviews do not have specific information regarding the use of a higher amount of a substance such as sulpiride. There is also no data on the effect of the above drug on the development of the fetal brain.
As a precaution, experts do not recommend taking this medicine to women in position. Although in some cases, treatment with the aforementioned preparation of patients is still allowed, what is expected of the baby, but strictly in minimal doses.
Experts note that if a mother received antipsychotic therapy for a long period of time, then newborn babies had problems with the functioning of the digestive tract (for example, bloating).
If a woman uses the medicine in the period before childbirth, then control of her body and fetal development by the doctor is mandatory.
It should also be remembered that the drug "Prosulpine" penetrates into breast milk. Instructions for use, reviews of experts are not advised to take it during lactation.
How to take the drug "Prosulpine"?
The manual suggests that patients use the above antipsychotic every 8 hours, one pill. It is not recommended to take the medicine after 16.00 hours, since its activity at this time is very increasing. It should be noted that the drug "Prosulpine" is used regardless of the meal and is washed down with a sufficient amount of liquid.
Tablets that contain 200 mg of sulpiride are taken for symptoms of acute schizophrenia, delirious psychosis, and depression. The drug can be taken in several stages. Its maximum daily dose is 100 mg, that is, about 5 pills.
The tablets, which include 50 mg of sulpiride, the instruction suggests taking if the patient has signs of neurosis, anxiety. Within 4 weeks, such patients should consume at least one and a maximum of 3 tablets per day.
Also, such pills can be taken for children with severe behavior disorders. The age of such patients must be above 6 years. The maximum daily dose for patients in this category is from 5 to 10 mg per 10 kg of body weight of the child.
Overdose
The instruction indicates that information on an overdose of sulpiride is limited. The following symptoms may occur with this condition in the patient:
- protrusion of the tongue;
- dyskinesia with spastic torticollis;
- blurred visual perception;
- dry mouth
- possibly the development of ZNS;
- extrapyramidal symptoms;
- increased sweating;
- nausea;
- sedative effect;
- gynecomastia;
- parkinsonism;
- increased blood pressure.
Treatment of the above condition of the patient is carried out as follows:
- the patientās stomach is washed;
- activated carbon is prescribed;
- systematic therapy is used.
If necessary, in especially severe cases, the doctor may prescribe additional manipulations, such as forced diuresis with infusion of alkaline solutions or monitoring of vital functions of the body.
It should be noted that this drug is partially excreted during hemodialysis.
Some categories of patients should take special precautions when using the drug "Prosulpine". This applies primarily to women with irregular periods, patients with severe hypotension and hypertension.
It is also important to conduct a preliminary electrophysiological and clinical examination in patients with epilepsy. It should be remembered that the drug "Prosulpine" lowers the threshold of convulsive activity.
In addition, when driving a vehicle, special care should be taken during the treatment period using the above medications. It is also important to limit activities that require quick psychomotor reactions and increased concentration of attention.
Interaction with other therapeutic agents
The instruction strictly does not recommend including the above drug in complex therapy with levodopa. Two active substances are antagonists. If a patient who suffers from Parkinson's disease takes levodopa, then the doctor must choose a drug that has minimal extrapyramidal effects.
Arrhythmias such as torsades de pointes can cause a combination of the drug "Prosulpine" with:
- antiarrhythmic drugs that belong to class Ia (drugs "Disopyramide", "Quinidine");
- drugs "Pimozide", "Haloperidol", "Thioridazine", "Cisapride", "Pentamidine", imipramine antidepressants;
- antiarrhythmic drugs that are included in the 3rd class (means "Sotalol", "Kakamiodaron");
- medications that cause symptoms of a disease such as bradycardia (beta calcium channel blockers);
- drugs that contribute to the appearance of signs of hypokalemia (laxatives that are stimulatory, hypokalemic diuretics, tetracosactides, glucocorticoids);
- dopamine antagonists (antiparkinsonian): Apomorphine, Amantadine, Lysurid, Ropinirol, Entacapone, Bromocriptine, Selegiline, Pramipexole, Piribedil);
- antipsychotics that have the ability to cause symptoms of pirouette tachycardia (Chlorpromazine, Amisulpride, Cyamemazine, Pimozide, Droperidol, Levomepromazine, Tiapride, Sertindol, Veralipride, Sulpiride) ;
- drugs that contain lithium (the latter significantly increases the risk of extrapyramidal disorders).
Also, in no case should the drug āProsulpineā be used with alcohol. The latter potentiates the sedative effect of antipsychotics.
In addition, if you take the above medicine in combination with centrally stimulating substances (anti-asthma drugs, anorectics), then the patient may experience symptoms of severe agitation, nervousness, anxiety, and anxiety.
It should be remembered that this antipsychotic drug lowers the level of effectiveness of ropinirole.
Substitutes of the medicinal product "Prosulpin"
Analogs of the above antipsychotic drug:
- "Betamak T100";
- "Vero-Sulpirid";
- "Betamax T50";
- "Depral";
- Betamax
- "Dogmatil";
- "Betamax T200";
- "Sulpiride";
- Egonil;
- Sulpiril;
- Egleck.
But to replace without prior consultation with the doctor does not recommend "Prosulpin" instructions for use. Analogs of it also have their individual side effects. They can be very harmful to the health of the patient.
Feedback on the remedy "Prosulpine"
Reviews about the above medicine are mostly positive. A lot of patients take it for depressive conditions. They claim that this tool helps to eliminate the symptoms of this disease by almost 100%.
In addition, there are a lot of responses from patients who took the drug Prosulpine for diseases such as schizophrenia, enterocolitis, colitis, psychosis, enteritis, peptic ulcer, irritable bowel syndrome. Their reviews indicate that in all cases this remedy produces an incredible therapeutic effect. In addition, patients note that side effects are very rare.
The drug considered above has serious side effects, so it is strictly forbidden to use it without first consulting a doctor.