The drug "Nimid" in various dosage forms refers to non-steroidal anti-inflammatory drugs with antipyretic, analgesic effects, is used for rheumatic lesions of the joints and soft tissues. Its main active ingredient is the analgesic nimesulide.
The medicine is produced by the Indian company Kusum Helthker HTP. Ltd. "
Kind of drug
The drug Nimid is available in solid, liquid and soft dosage form :
- one-component tablets for oral administration;
- Forte oral tablets;
- granular powder for oral administration;
- gel for external use;
- suspension for oral administration.
Conventional-release tablets contain 100 mg of nimesulide. They are packaged in blisters of 10 pieces, packed in packs of 10, 30 or 100 tablets.
Nimid Forte tablets manufactured by New Life (India) contain two active components: nimesulide in an amount of 100 mg and tizanidine hydrochloride, equivalent to 2 mg of tizanidine. They are packaged in blisters of 10 pieces and packed in packs of number 10. They have a prolonged action.
The drug "Nimid" - granular powder - is packaged in sachets of 2 g. Each dosage unit contains 100 mg of nimesulide. The Nimid medicine (granules) is sold for 30 sachets per pack.
The gel for external application contains 10 mg of nimesulide in 1 g of the drug. Often this dosage form is mistakenly called this: Nimid ointment. The gel is packaged in tubes of 20, 30 and 100 g, packed in packs.
A 1 ml oral suspension contains 10 mg of the active ingredient. Available in bottles of 60 ml.
How does the drug work?
The mechanism of action of the Nimid drug (gel) associates the instructions for use with the pharmacological characteristics of the active substance. Nimesulide has the ability to anesthetize, lower the temperature and reduce inflammation. It is a non-steroidal anti-inflammatory drug. Its chemical formula does not contain a carboxyl group.
Nimesulide is able to selectively inhibit type 2 cyclooxygenase, disrupt the synthesis of prostaglandin substances and leukotrienes. The anti-inflammatory effect is associated with inhibition of the release of histamine by mast cells, inhibition of the formation of a factor responsible for the activation of platelet cells, tumor cell necrosis factor. The drug does not allow bradykinin and cytokine to be synthesized, it is they that cause pain, which causes the analgesic effect of the active substance.
The drug Nimid (tablets) with a prolonged action contains a muscle relaxant in the form of tizanidine hydrochloride with a central effect. With his participation, the reflexes of the polysynaptic reflex arc in the spinal cord are suppressed, the muscle tone changes. Tizanidine relieves acute painful muscle or chronic spasm of spinal and cerebral origin.
An important feature of the active component of tablets is the ability to reduce the formation of superoxide anion radical, which damages proteins with iron-sulfur clusters. This, in turn, keeps tissues and many enzymes from destruction.
What heals
Means "Nimid" (gel) instructions for use recommends using for complex therapy of degenerative inflammatory lesions of the musculoskeletal system. Locally, it is used for edema and pain accompanying rheumatoid, rheumatoid, psoriatic and gouty arthritis, ankylosing spondylitis, osteoarthritis, Reiter’s disease, myalgia, tendonitis, myositis, tendosynovitis.
The drug treats radicular syndrome with osteochondrosis, backache, neuralgia with multiple sclerosis, cerebral palsy, sciatic nerve inflammation, degenerative diseases of the spinal cord. An effective gel to relieve inflammation in the soft tissues after an injury associated with rupture and damage to ligaments, contusion and stretching of muscle fibers.
The Nimid medication (tablets, granules and suspension) is used to eliminate the symptoms of pain in the bones, joints and muscles associated with osteoarthritis, rheumatoid arthritis, bursitis, tendonitis, myalgia.
The analgesic properties of the drug are used for post-traumatic and postoperative pain, gynecological diseases (primary algodismenorrhea, adnexitis), ENT diseases and dental problems, manifested by inflammatory processes and pain.
Antipyretic effect effectively relieves fever in diseases of the upper respiratory system and ENT organs.
Use of tablets
The drug "Nimid Forte" with a prolonged action is used not on an empty stomach, but after a meal, washed down with liquid.
Rheumatic diseases, degenerative-dystrophic disorders of the musculoskeletal system and neurological diseases are treated according to this scheme: one tablet in the morning and one in the evening.
To eliminate the pain syndrome with muscle spasm, adults are prescribed a three-time intake of 1 tablet. Dosage and duration of treatment can be changed by a doctor, depending on the degree of the disease.
Pain in the inflammatory process or after surgery is eliminated by tablets within 5 days. If the effect is negligible, the selection of another drug is required.
One-component Nimid tablets are taken after breakfast and dinner, 1 pc. no more than 15 days. It is allowed to use for children from 12 years old.
Suspension use
Suspension "Nimid" drink after eating. For adults, the daily dose is 100 mg. The maximum dose per day should not exceed 400 mg, it is divided into two doses.
For children after 12 years of age, a suspension preparation is given in a daily dosage of 1.5 mg per kg of body weight in two divided doses. The maximum dose for small patients per day should not exceed 5 mg per kg of weight. The instructions for use indicate that children over 12 years old with a body weight of more than 40 kg are prescribed a dose of 100 mg, divided into two doses. The maximum allowable amount of nimesulide should not exceed 200 mg.
Gel application
For external use of Nimid (gel), the instructions for use provide for applying to the affected area a column of the drug, the length of which is about 3 cm. Then, smear the medicine well over the surface of the skin and allow it to dry. During the day, this procedure is carried out from 3 to 4 times. The skin of the affected area should be clean and dry, only in this case, you can apply the product.
After applying the Nimid gel, patients leave mostly positive reviews. It is especially effective for bruises. With its help, pain, swelling of soft tissues are quickly removed, the cells of the damaged area are rapidly regenerated, which leads to the healing of the sore spot. Many people suffering from frequent injuries, bruises, sprains and muscles, Nimid gel is always in the medicine cabinet.
With the complex treatment of rheumatic manifestations, the medicine is applied to the area of the diseased joint, which reduces the inflammatory process.
The relatively small price for the Nimid Gel preparation (from 160 to 180 rubles per package) makes it affordable for most buyers.
Application of granules
Another form of the drug for oral administration requires preliminary preparation.
The drug "Nimid" (powder) before use, the instructions for use recommends diluting in warm water. From one sachet, granules are poured into a glass of water (200 ml of liquid), mixed to dissolve the drug. The prepared solution is immediately drunk.
For adults and children from 12 years of age, the drug is prescribed in a dosage of 100 mg, which corresponds to one sachet, 2 times a day after breakfast and dinner. The duration of treatment should not exceed 15 days.
Undesirable consequences
The use of the drug "Nimid" in granules can lead to such adverse reactions:
- to skin rashes, itching, urticaria, angioedema, rarely - to epidermal necrolysis, Stevens-Johnson syndrome;
- nausea, pain in the stomach, constipation, indigestion, rarely peptic ulcer of the duodenum and stomach, gastrointestinal bleeding, ulcerative perforations;
- to changes in transaminase activity, rarely to acute hepatitis;
- drowsiness, dizziness, headaches;
- to a decrease in the amount of urine excreted, edema, rarely - to insufficient kidney function and excretion of blood with urine;
- rarely - bleeding on the background of thrombocytopenia and an increased number of megakaryocytes;
- rarely - to anaphylactic reactions with bronchospasm, shortness of breath.
The use of the drug "Nimid" in tablets and in suspension may lead to the following adverse reactions:
- skin rashes, itching, erythema, increased sweating, dermatitis, rarely - angioedema, erythema multiforme, edema of the facial part of the head, urticaria, epidermal necrolysis, Stevens-Johnson syndrome;
- pain symptoms in the stomach, nausea, constipation, indigestion, flatulence, rarely - black semi-liquid stool with a bad smell, stomatitis, peptic ulcer of the duodenum and stomach, bleeding in the digestive tract;
- to cholestasis, jaundice, changes in transaminase activity, rarely - to acute hepatitis;
- drowsiness, dizziness, headaches, non-inflammatory lesions of the brain;
- to a nervous state, anxiety, nightmares;
- to urination disorder, edema, urinary excretion of blood, urination retention, rarely - to insufficient kidney function and interstitial nephritis ;
- to an increase in the number of eosinophils, a lack of hemoglobin, rarely - to bleeding on the background of thrombocytopenia and an increased number of megakaryocytes, hypoplasia of blood cells during hematopoiesis, a lack of platelets, bleeding;
- to anaphylactic shock ;
- difficulty breathing, rarely - bronchospasm, bronchial asthma;
- to increased pressure, an increase in the frequency of contractions of the heart muscle, rarely to a sensation of hot flashes, fluctuations in blood pressure;
- to an asthenic state, visual impairment, increased potassium in the blood, lower body temperature.
- undesirable consequences of treatment with the Nimid drug (gel), the instructions for use also describe: peeling of the skin, itching, urticaria at the site of application.
In severe cases, which are very rare, anaphylactic reactions occur, characterized by vasomotor rhinitis, Quincke's edema, bronchospasm, suffocation.
Who is contraindicated in treatment
Not all people can use Nimid in granules, tablets, or in suspension. Contraindications are:
- peptic ulcer of the duodenum and stomach in the acute stage;
- severe violations of the liver when there is liver failure;
- hepatotoxic reactions to the components of the drug in the past;
- severe renal impairment, when less than 30 ml of creatinine is excreted per minute;
- concomitant use with drugs harmful to the liver;
- possible bleeding;
- heart muscle failure;
- hypersensitivity to nimesulide and other components of the drug;
- pregnancy;
- breast-feeding;
- children under 12 years old;
- chronic alcoholism or drug addiction;
- fever and flu;
- possible surgical pathologies.
Gel "Nimid" is not used for:
- hypersensitivity to nimesulide and other components of the drug;
- when there are dermatitis, infections or damage to the skin in the affected area;
- bronchial asthma from taking acetylsalicylic acid;
- children under 12 years old;
- pregnancy, in the third trimester.
Analogs
The original drug based on nimesulide is considered "Mesulide" manufactured by the Irish company "Helsin Bireks."
The drug "Nimid" has analogues among generics reproduced on the basis of the original. The main synonyms include such drugs "Nimesil", "Nimegesic", "Remixid", "Nimesulide", "Nise", "Nimid Forte".
The manufacturer of "Nimesil" is the company "Laboratory Guidotti S.p.A." (Italy), although the medicine itself is produced at the Spanish company "Laboratorios Menarini S.A." The tablets contain the active substance nimesulide in an amount of 100 mg, which refers to non-steroidal anti-inflammatory drugs from the sulfonanilide class.
An analogue is the tool "Remisid" produced by FF "Darnitsa". Available in the form of a gel for external use with a content of 10 mg of nimesulide in 1 g of the drug. It is used to treat pathologies of the musculoskeletal system.
The Indian synonym "Nimegesic" of the manufacturer "Alembic Limited" is available in the form of granules for the preparation of a solution or suspension for oral administration, suspension, dispersible tablets, for dissolving and soluble in water.
The Russian analogue of the Nimesulide medication manufactured by Obolenskoye Pharmaceutical Enterprise CJSC is produced in the form of tablets with a dosage of 100 mg of nimesulide. This tool has an anti-inflammatory, analgesic and antipyretic effect in various pathological processes of the skeleton and soft tissues of the human body.
The drug Nise, manufactured by Dr. Reddy's Laboratories Ltd, is available in conventional and dispersible tablets, in the form of a suspension for oral administration, in the form of a gel for external use.