"Neo-Penotran" is a drug with a pronounced antiparasitic, antibacterial and antifungal effect. The medication is intended for local use, it is used in gynecological practice.
Description of the drug
"Neo-Penotran" refers to combination preparations, which immediately include two active substances:
1. Miconazole, has an antifungal effect.
2. Metronidazole, harmful to harmful bacteria.
Together, these substances in the composition of Neo-Penotran eliminate pathogenic microorganisms that provoke the appearance of candidiasis, disturbance of the vaginal microflora and the inflammatory process of the mucous membrane.
Providing antiprotozoal, antibacterial and antifungal effects, the drug actively and purposefully fights against the problems of the female body of a gynecological nature.
Release Forms
There are several options for the drug "Neo-Penotran". All of them are available in the form of vaginal suppositories, seven pieces in one package. The types differ in name and number of active components:
1. "Neo-Penotran." Its composition includes 0.5 g of metronidazole and 0.1 g of miconazole. It also includes additional components.
2. "Neo-Penotran Forte." 0.75 g of metronidazole and 0.2 g of miconazole. The reinforced composition produces a much more active action aimed at the destruction of parasitic organisms.
3. "Neo-Penotran Forte L". It contains 0.75 g of metronidazole and 0.2 g of miconazole. The composition of this form of the drug is also supplemented with lidocaine.
Properties of the drug and indications for use
The effectiveness of the drug is due to the action of its main components - metronidazole and miconazole. They actively fight bacteria and fungi, and also have an anti-inflammatory effect.
Due to its composition, Neo-Penotran is able to withstand the following types of pathogenic pathogens:
1. Gardnerella.
2. Trichomonads.
3. Anaerobic bacteria, including anaerobic streptococcus.
4. Pathogenic fungi such as candida.
Also, the drug is active against gram-positive bacteria.
"Neo-Penotran" is prescribed to women for the treatment of various gynecological diseases. The drug is prescribed for such diagnoses:
1. Candidiasis of the vaginal type.
2. Trichomonas vaginitis.
3. The mixed form of vaginitis.
4. Bacterial vaginitis.
5. Vulvovaginitis caused by fungal pathogens.
Another area of ​​use of the drug is the prevention of fungal and bacterial infections before and after surgery. Clinical studies have shown that the drug significantly reduces the likelihood of complications in the postoperative period.
We will figure out how to take Neo-Penotran during pregnancy.
Contraindications
Vaginal suppositories can not be used for certain physiological and pathological conditions of the female body, namely:
1. The first trimester of pregnancy.
2. Virginity.
3. Children's age up to 18 years.
4. Severely impaired liver function.
5. Epileptic seizures.
6. Porphyria.
7. Individual reaction to suppository components, including a local allergic reaction.
It is indicated above that this medicine cannot be used at the beginning of pregnancy. In the future, starting from the second trimester, the Neo-Penotran suppositories during pregnancy can be used, but only if absolutely necessary. In this case, the doctor should adequately assess the potential risk to the fetus and woman when using suppositories.
Breastfeeding for the period of treatment with vaginal suppositories “Neo-Penotran” should be abolished. It will be possible to return to lactation a few days after completion of therapy.
Mode of application
Vaginal suppositories need to be injected deep into the vagina. In this case, you can use special fingertips, which are sold complete with suppositories. There are standard treatment regimens:
1. Intravaginal administration of one suppository at bedtime for a week.
2. If the patient is given a relapsing form of vaginitis, as well as when treatment with other drugs does not give a result, the use of Neo-Penotran can be extended to two weeks.
Elderly age is not a contraindication for drug treatment and does not require adjustment of standard dosages.
Adverse Reactions and Overdose
Consider the side effects of Neo-Penotran. Like any other drug, this medication is able to have a negative effect on the woman’s body and provoke the development of a number of undesirable reactions, including:
1. Change in clinical blood counts, including a decrease in white blood cell count.
2. An allergic reaction, accompanied by urticaria, itching, swelling, rash, facial flushing, and anaphylactic shock.
3. Nausea and vomiting, diarrhea and constipation, decreased appetite, dry mouth and metallic taste, stomatitis, soreness in the abdomen, violation of taste buds.
4. Discomfort in the vagina, manifested by burning and itching, redness and irritation. If the severity of irritation increases, it is necessary to stop using suppositories and consult a doctor.
5. On the part of the nervous system, increased fatigue, weakness and dizziness, convulsive syndrome, sudden changes in mood, short temper, headache, false sensations, etc. are possible.
The instructions are not stated, but (judging by numerous reviews), uncharacteristic blood or pink discharge often appears after Neo-Penotran.
There can be many reasons, therefore, if a similar symptom occurs, you should immediately contact your doctor. An examination will show what caused this reaction of the body.
As soon as the treatment is completed, the above symptoms will go away on their own, so they do not require specific treatment. In the case of using Neo-Penotran Forte L, adverse reactions can occur as a result of low absorption of lidocaine.
To date, there are no data on cases of overdose. If the candle was accidentally taken inside, you should immediately carry out the procedure of washing the stomach and intestines, as well as take sorbents. When a significant amount of metronidazole is absorbed, symptomatic treatment is necessary, since there is no specific antidote to it.
Can I use Neo-Penotran during menstruation?
It is advisable to start the course of treatment one and a half to two weeks before menstruation. Suppositories with menstruation may not have the proper therapeutic effect. If necessary, you can lay the medicine on days of minor discharge. As a rule, with genital infections, complex therapy is prescribed. At the time of critical days, it is necessary to stop treatment, and then use the missed candles according to the scheme.
Special recommendations
Before using suppositories, you should familiarize yourself with some recommendations:
1. If we are talking about the treatment of trichomonas vaginitis type, then the therapy must be carried out together with a sexual partner.
2. The specialist should inform the patient about the method of using the drug in order to avoid accidental swallowing.
3. With caution, suppositories should be used simultaneously with barrier contraceptives, as they can be damaged by the introduction of suppositories.
4. Avoid drinking alcohol during treatment. After completing the course of therapy, at least a day should pass before drinking alcohol. This is due to the fact that the combination of metronidazole and ethanol can lead to the development of disulfiram-like reactions.
5. When using suppositories, indicators of the level of liver enzymes, theophylline, glucose and procainamide can change, as well as other clinical results of a blood test.
The research results showed that when using suppositories there is no risk of specific complications. The drug is practically safe, non-toxic. In addition, the active components do not affect the reproductive functions of women.
Interaction with other drugs
Before the first use of Neo-Penotran vaginal suppositories, it is necessary to study their interaction with other drugs:
1. Simultaneous use with lithium leads to increased toxicity of the latter.
2. In combination with phenobarbital, the concentration of metronidazole is reduced.
3. The anticoagulant effect of various drugs is enhanced by the influence of Neo-Penotran.
4. The simultaneous use of suppositories with disulfiram can provoke undesirable reactions from the nervous system.
5. In combination with cimetidine, an increase in the concentration of metronidazole may occur, and the likelihood of adverse reactions from the nervous system also increases.
6. "Phenytoin" lowers the concentration of metronidazole, while the level of the substance itself rises.
7. Simultaneous administration with Astemizole and Terfenadine leads to an increase in their concentration in blood plasma while suppressing their metabolism.
Analogs of Neo-Penotran
If intolerance to the components of the drug has been identified, you can choose a similar drug from the following list:
1. "Ketonazole."
2. "Klomezol."
3. "Trichopol".
4. "Klevazol."
5. “Gravagin”.
6. Livarol.
7. Mikogal.
8. "Ginalgin."
9. "Pulsitex."
10. "Metromicon-Neo."
All of the listed analogues of Neo-Penotran have similar actions to it, but their compositions differ significantly. Therefore, before using them, you must consult a specialist.
Price
The cost of the drug is 600-700 rubles per package. The price depends on the region and the pharmacy chain.
Opinions of patients and specialists
Reviews of vaginal suppositories are rather controversial and ambiguous. In many of them, the drug is highly effective in combating thrush and various types of vaginitis. The advantages of this drug women include the convenience in the use of suppositories and their quick action. The course of treatment is only a week, while the result comes only a few days after the start of therapy.
One of the drawbacks of the patient’s drug is its high price, which often exceeds 500 rubles per package. Another significant drawback of the drug is discomfort in the vagina during the treatment period, accompanied by itching and burning. No less complaints are caused by the fact that the melted candle flows out. It is rather difficult to judge the effectiveness of the drug, taking such reviews as a basis.
Doctors also write about the price of Neo-Penotran in reviews that it is overpriced. The chemical composition of the drug is quite simple