Currently, medicine knows a huge number of diseases associated with inflammatory processes in various systems of internal organs. To combat pathologies, it is important to choose the most effective tool that will help to quickly get rid of the disease and not provoke serious side effects. One of them is Meloxicam-Teva. Instructions for use, reviews will be presented below.
The drug: its composition and form of production
The drug relates to derivatives of enolic acid. Helps fight heat, relieves pain and has an anti-inflammatory effect. The drug inhibits the activity of cyclooxygenase, which leads to a suppression of the production of prostaglandins, which act as mediators of inflammatory processes.
The main component is meloxicam. Meloxicam-Teva tablets also contain additional components:
- Monocrystalline cellulose.
- Lactose Monohydrate.
- Povidone.
- Sodium citrate dihydrate.
- Magnesium stearate.
- Colloidal silicon dioxide.
- Crospovidone.
The manufacturer produces "Meloxicam-Teva" in tablet form containing 7.5 or 15 ml of the active substance.
The drug is also available in the form of a solution for injection in ampoules of 1.5 ml. The content of the main active substance is 15 mg.
The solution "Meloxicam" composition has the following, if we consider additional components:
- Meglumine.
- Poloxamer.
- Glycine.
- Sodium chloride.
- Sodium hydroxide.
- Tetrahydrofurfuril Macrahol.
The solution for injection has a yellow color and a slightly greenish tint.
Pharmacodynamics
After ingestion in the gastrointestinal tract, the drug is almost completely absorbed, bioavailability is about 90%. The maximum content of the main substance in the blood plasma is detected 5-6 hours after a single use. The quality of absorption is not affected by food intake.
Meloxicam binds perfectly with proteins, especially with albumin, penetrates into the synovial fluid. The main metabolism of the drug is carried out in the liver. Excretion with urine and feces within 15-20 hours. Problems of a minor nature in the work of the liver and kidneys do not lead to the accumulation of the active substance in the body.
What does “Meloxicam-Teva” help?
The drug has proven its therapeutic effect in the treatment of many pathologies. The instructions for the medicine contain detailed information. "Meloxicam-Teva" indications for use has the following:
- Arthritis.
- Arthritis of a rheumatoid character.
- Osteoarthritis in acute form.
- Chronic form of polyarthritis.
- Spondylitis
- Osteoarthrosis.
- To relieve pain in diseases of the joints, with osteochondrosis and radiculitis.
Meloxicam-Teva injections are prescribed to relieve an acute pain symptom in case of rheumatoid arthritis or spondylitis, if the tablets do not bring the desired effect or if it is not possible to take them orally.
Who is contraindicated with Meloxicam-Teva therapy?
There is a category of pathologies and conditions in which it is not recommended to prescribe this drug:
- Excessive susceptibility to the main active ingredient or any auxiliary component.
- Allergic reactions to acetylsalicylic acid and parasolone group drugs and the presence of a history of data on the development of allergic rhinitis, urticaria with any NSAIDs.
- The recovery phase after coronary bypass surgery.
- Bronchial asthma.
- Polyposis of the nasal cavity and sinuses.
- The presence of ulcerative pathologies of the stomach and intestines.
- A history of intestinal and gastric bleeding.
- Inflammatory processes in the small and large intestines, such as Crohn's disease or colitis.
- Hereditary diseases: lactose intolerance.
- Cerebrovascular bleeding.
- Heart failure.
- Severe renal pathology.
- Pregnancy.
- Breast-feeding.
- Age to 15 years.
If you consider contraindications for injection of “Meloxicam-Teva”, then they are the same, but you must add:
- Blood clotting disorder.
- Hyperkalemia
- Age to 18 years.
All these contraindications must be taken into account, the instructions for “Meloxicam-Teva” contain this information.
The scheme and dosage of the drug in tablets
Given that drug therapy in large dosages and with prolonged use is fraught with serious side effects, “Meloxicam-Teva” (the instructions for use confirm this) should be used in short courses and in a minimally effective dosage.
It is advisable to take the drug once a day, before meals, with plenty of water. The dosage is recommended as follows for various pathologies:
- If you are diagnosed with arthritis or spondylitis, then a medicine is prescribed 15 mg once a day. If a good therapeutic effect is observed, then the dosage can be halved.
- To treat osteoarthritis, take 7.5 mg per day, if necessary, the dose can be increased to 15 mg. It should be borne in mind that for an age older than 15 years, the dose is calculated at the rate of 0.25 mg per kilogram of body weight.
- In the treatment of elderly patients, the initial dose should not exceed 7.5 mg.
- If there are slight deviations in the functioning of the liver and kidneys, then it is not necessary to reduce the dosage.
During treatment with the drug, it is necessary to monitor your condition and if you detect adverse events, tell the doctor.
Injection Therapy
Injections "Meloxicam-Teva" instructions for use recommends use in treatment as follows:
- The drug is injected deep into the muscle.
- Therapy is allowed during the first days, and then the transition to tablets is carried out.
- With a diagnosis of osteoarthritis, 0.5 ampoules (7.5 mg) per day are initially prescribed. If the doctor considers it necessary, the dosage can be increased to 15 mg.
- To stop the acute form of arthritis or spondylitis, 1 ampoule is prescribed once a day. When observing a good effect, the dosage is reduced by half.
- In the presence of minor deviations in the functioning of the excretory system and liver per day, the dosage is 7.5 mg.
Treatment is carried out under the supervision of a doctor.
Taking the drug if there are problems with the kidneys and liver
If a patient with chronic renal failure does not undergo dialysis, there are serious progressive pathologies of the kidneys, then admission is strictly prohibited. The clearance of 30-60 ml / min in renal failure allows the use of the drug, but only under the constant supervision of doctors.
Minor deviations and clearance of 30 ml / min allow you to take the medicine in the recommended dosage.
The presence of progressive liver diseases is a categorical ban on Meloxicam-Teva therapy. Under special control, such therapy is prescribed if a diagnosis of cirrhosis is made.
Side effects during therapy
It should be noted that Meloxicam-Teva tablets, when taken, can provoke the following undesirable effects:
- Digestive tract disorders: nausea and vomiting, abdominal pain, stool disturbance are often observed. Some patients noted the development of stomatitis, belching, bleeding in the digestive tract. Very rarely, hepatitis, colitis or gastritis were diagnosed.
- Reception "Meloxicam-Teva" (instructions for use describes such cases) often provokes the development of anemia, sometimes tests show thrombocytopenia, leukopenia or agranulocytosis.
- Rashes, itching, urticaria appear on the skin. Toxic epidermal necrolysis, erythema and photosensitivity rarely develop.
- On the part of the respiratory system, bronchospasm is noted. If there is an increased sensitivity to acetylsalicylic acid, an asthma attack may develop.
- The nervous system can respond to Meloxicam-Teva therapy (reviews confirm this) with headaches, dizziness, fatigue and drowsiness. Rarely there is confusion, emotional instability.
- If there is a tendency to hypertension, then taking the drug can provoke an increase in pressure, a violation of the heart rhythm. Some patients report swelling and hot flashes.
- Urinalysis shows a change in renal function, rarely develops kidney failure, nephritis.
- The organs of vision can also be affected: the clarity of vision is violated, conjunctivitis develops. The vestibular apparatus may be affected, then tinnitus appears, disorientation in space.
- Very rarely, allergic reactions to the drug are observed.
- The liver suffers, jaundice is manifested, hepatitis and liver failure develop.
- Some patients noted the appearance of pain in the back, joints.
- Patients to whom the drug was prescribed in injections note the appearance of pain at the injection site, swelling, swelling, which can even affect the legs. Some speak of a flu-like condition.
If injections are prescribed with Meloxicam-Teva, patient reviews report the same side effects.
Symptoms of an overdose of the drug
Some patients mistakenly believe that taking a drug at a higher dosage will speed up the healing process. This is a big mistake, because an overdose of "Meloxicam-Teva" (instructions for use warns about this) is fraught with the following complications:
- Nausea and vomiting.
- Severe stomach pain.
- Impaired consciousness.
- Drowsiness and apathy.
- There is a risk of bleeding in the stomach or intestines.
- The development of renal failure.
- Liver failure.
- Asystole.
- Respiratory arrest.
- Coma.
- Heart failure.
- Anaphylactic shock.
- Heart failure.
If the patient has taken an excess dose of the drug, then an urgent need to rinse the stomach, take activated charcoal. Further, symptomatic therapy is required. Studies have shown that colestyramine is able to bind meloxicam in the intestine, which contributes to its rapid elimination.
"Meloxicam-Teva" during pregnancy
Women during child bearing therapy with this drug is strictly prohibited. Reception is allowed only in case of emergency and in a minimum dosage. There is evidence of research that confirms that Meloxicam-Teva therapy in the first trimester can lead to heart defects in the baby, as well as a miscarriage. The longer the therapy will be carried out and with a higher dosage, the higher the risk.
“Meloxicam-Teva” (the instruction contains such information) is also unsafe to take in the last trimester, it can provoke the following violations:
- The development of pulmonary hypertension in the fetus.
- Premature closure of the ductus arteriosus.
- Impaired functioning of the kidneys, renal failure sometimes develops.
- Prolonged bleeding in the mother.
- Decreased uterine contractility, which can increase the duration of labor.
Important directions for taking Meloxicam-Teva
There are groups of patients who are not prohibited from drug therapy, but treatment should be treated with extreme caution. Cautions include the following:
- Patients who have a history of gastrointestinal pathology, therapy should be under constant medical supervision.
- If there is an intake of anticoagulants, then the risk of developing erosive lesions increases.
- The presence of diseases of the stomach and intestines increases the risk of intestinal bleeding, ulcers, perforations, especially in elderly patients.
- If rashes, itching appeared on the skin during therapy, then it is worth discussing with the doctor the issue of reducing the dosage or replacing the drug.
- If during treatment the patient has an increase in the activity of hepatic transaminases in the analyzes, then the medication should be discontinued.
- In patients with impaired blood flow in the kidneys, Meloxicam-Teva therapy (instructions for use, reviews confirm this information) is fraught with decompensation of latent renal failure. Most often, such a complication is observed in patients of retirement age, in the presence of heart failure, liver cirrhosis, and serious kidney pathologies.
- Caution must be taken when treating a patient with diuretic drugs, ACE inhibitors, or undergoing surgery.
- In the presence of hereditary intolerance to galactose or lactase deficiency, the drug should not be taken.
- Care should be taken to drive vehicles, especially if there are impaired vision clarity among the side effects.
- Reception at the same time "Meloxicam-Teva" and diuretic drugs should be accompanied by the use of a large amount of liquid.
- The medicine is carefully prescribed for elderly patients due to the presence of serious adverse events.
- Serious complications can be noted while taking alcoholic drinks or somatic pathologies.
- Necrotic syndrome requires careful administration of the drug.
- Coronary heart disease.
- Diabetes.
- The presence of pathologies of peripheral vessels.
- Smoking.
- Taking glucocorticosteroids.
- Before you start therapy, you need to think about women who plan to become pregnant in the near future. The drug negatively affects reproductive function.
If Meloxicam-Teva injections are prescribed by a doctor, the instructions for use draw attention to the same features of therapy.
Compatibility with other medicines
Before prescribing Meloxicam-Teva, the doctor must talk with the patient and find out what drugs he is taking at the moment. Some drugs simply do not combine with each other, but it happens that taking them together leads to serious negative consequences. If Meloxicam-Teva tablets are prescribed, the instructions for use warn:
- It is not recommended to combine with the intake of acetylsalicylic acid or other NSAIDs, since there is a high risk of developing intestinal bleeding and ulcerative lesions.
- “Meloxicam” will lower the effectiveness of drugs for high blood pressure.
- Medications containing lithium in combination with the drug can lead to lithium intoxication.
- Admission against the background of "Meloxicam-Teva" "Methotrexate" is fraught with the development of anemia and leukopenia.
- Taking diuretics may result in the development of renal failure.
- The main substance of the drug reduces the effectiveness of intrauterine contraceptives.
- Reception of "Heparin", "Ticlopidine", "Fibrinolizine" together with "Meloxicam-Teva" may result in bleeding.
- "Cholestyramine" promotes the rapid elimination of "meloxicam", which reduces its effectiveness.
- “Cyclosporine” increases its toxicity if taken simultaneously with “Meloxicam”.
If you are taking medications that are not listed, but found undesirable effects during treatment with Meloxicam-Teva, you should inform your doctor.
Analogues of the drug
If we consider drugs with the same composition, then for "Meloxicam-Teva" analogues can be called the following:
- Amelotex. Available in tablets as well as in ampoules for injection. There are also gel and suppositories.
- "Arthrosan." You can buy pills and a solution for injections.
- Tablets "Bi-Xikam."
- Liberum.
- "Melox."
- Solution for injection "Meloxicam DS".
- Suppositories "Meloxicam Canon".
- Injections "Meloflex Rompharm."
- "Mesipol" for intramuscular administration.
- Tablets and ampoules "Movalis".
- Movasin.
- Oxycamox.
- Flexibon.
When choosing an analogue, it is always necessary to consult with your doctor. The active substance may be the same, but additional components can cause unwanted effects. When appointing a medicine, only a doctor takes into account not only pathology, its degree, severity, but also the patient’s age, state of health, and the presence of concomitant pathologies. Therefore, do not self-medicate and prescribe medications for yourself.
Reviews about "Meloxicame-Teva"
If you listen to the reviews of doctors, then they are inclined to the fact that the drug is quite effective. Helps to eliminate pain, relieve inflammation. But there is one caveat: the drug is able to provide the maximum therapeutic effect only with monotherapy, and this is rare in medical practice. This is explained by the fact that, as a rule, by the age when diseases of the joints and spine begin to bother, the body already has a whole bunch of pathologies, each of which requires its own treatment and medication. This is where the incompatibility of “Meloxicam-Teva” with other drugs arises, which affects the effectiveness of therapy.
If you listen to patients, then taking Meloxicam-Teva tablets leaves mixed reviews. Some note the good effectiveness of the drug. In the course of treatment:
- Pain syndrome decreased.
- The drug coped with the inflammatory process.
- Improved mobility in the joint or back.
- Pain in the cervical spine that was triggered by osteochondrosis disappears.
But some patients noticed less effectiveness compared to other drugs in the same group.In addition, undesirable manifestations are often noted, especially the gastrointestinal tract. But there is one plus: there were cases when it was precisely with the beginning of the Meloxicam-Teva therapy that it was possible to diagnose a pathology of the stomach or intestines, and the medicine simply revealed this disease.
It should be noted that it is impossible for all patients with the same diagnosis to choose a universal drug that will help everyone. The body of everyone is different and in its own way responds to the intake of certain drugs. In addition, the presence of chronic pathologies affects. That is why it is impossible to give an unambiguous answer to the question of whether the drug is good or not. Will he help to cope with the disease or not? It helps one perfectly and does not provoke side effects, and will not give help to the second patient, and will cause so many undesirable consequences that will have to be fought for a long time.
So all the questions on the purpose of the medicine, the treatment regimen and dosage are all purely individual.