The drug Concor Kor is available in coated tablets weighing 2.5 mg. The active ingredient of the drug is bisoprolol hemifumarate in a ratio of 2: 1. Excipients are corn starch, calcium hydrogen phosphate, cellulose, magnesium stearate and other substances. Pharmacological and clinical characteristics. The pharmacological effect is to reduce renin activity, significantly reduces myocardial oxygen consumption and heart rate. The drug is indicated for moderate and severe chronic heart failure. The maximum action shows 1-3 hours after administration, valid for 24 hours. Concor Cor is prescribed when chronic heart failure is being treated , but the drug is not prescribed alone, but in combination with a diuretic, ACE inhibitor, and, if necessary, cardiac glycoside.
Dosage regimen and duration of drug use (in mg / day)
First week 1.25
Second week 2.5
Third week 3.75
Fourth to fifth week 5.0
Eighth to twelfth week 7.5
After the twelfth week 10.0
Tablets are taken once a day. The maximum dose per day is 10 mg at a time. The tablets are swallowed whole, washed down with water. Concor Cor is recommended to be taken in the morning during breakfast or on an empty stomach. Treatment with Concor Cor is usually of a long-term nature. If necessary, treatment can be suspended, while the dose should be reduced gradually. Side effect at the beginning of the course, the first two weeks: dizziness, fatigue, headache, manifestation of depression, sleep disturbance are possible. Perhaps a decrease in tear secretion, conjunctivitis. In some cases, bradycardia and orthostatic hypotension, a feeling in the limbs of cold and goosebumps are possible. In patients with a tendency to bronchospasm, shortness of breath may occur. There have been isolated cases of dry mouth, constipation, vomiting, diarrhea, nausea, hepatitis, and abdominal pain. Dermatological reactions are possible - itching, sweating, redness of the skin, rash. Sometimes cramps in the legs, muscle weakness. In patients with psoriasis, its course may worsen.
Contraindications
Concor Cor is not used for cardiogenic shock, acute heart failure, in the stage of overt decompensation in the presence of chronic heart failure, collapse, AV block II, III degree, sinoatrial blockade, CVD, Prinzmetal angina, severe bradycardia (more than 50 strokes per minute), expressed a decrease in blood pressure (less than 90 mmHg), severe bronchial asthma, Raynaud’s disease, metabolic acidosis. The safety and effectiveness of the drug when used in childhood and adolescence has not yet been established.
Use during pregnancy
During pregnancy and lactation, the drug Concor Cor should not be used, experience with this category is insufficient. If, nevertheless, the drug is used in some cases during pregnancy, then its use should be discontinued at least seventy-two hours before the date of the intended birth. Because there is the possibility of the appearance of bradycardia, a decrease in blood sugar and respiratory depression in a newborn. If the fetus has other problems with the vascular system, the drug may aggravate them.
Overdose
Symptoms of an overdose are bronchospasm, hypotension, bradycardia. It is necessary to stop taking the medicine, take the sorbent and urgently call a doctor.
Terms, storage periods
The medicine Concor Kor is stored at a temperature not exceeding 25 ° C. The storage location should be out of the reach of children, as there is a risk of poisoning. The shelf life of Concor Bark is 3 years.