Groprinosin Syrup is an antiviral drug designed to stimulate the human immune system. Designed to treat children. The medicine is prescribed from the age of one. Groprinosin in liquid form can be used not only by children, but also by persons older. Consider the features of the activity of the drug.
Pharmacology
Groprinosin Syrup for Children belongs to the class of immunostimulating pharmaceutical products with activity against viruses. This is a complex medication, in which, along with inosine, there are products of the processing of 4-acetamidobenzoic acid. The second substance is present in a three times greater volume than inosine, whose presence largely guarantees the pronounced effect of the drug. Acid salt is an additional ingredient that improves the availability of inosine to lymphocytic cell structures. The drug, entering the body, inhibits the reproduction of viruses, as it corrects the genetic structure of pathological microscopic particles. At the same time, more pronounced work of microphages is initiated, lymphocytes divide faster. Under the influence of the agent, cytokines are more actively generated. Proper use of syrup can reduce the clinical symptoms of viral invasion and increase the rate of convalescence. The resistance of the body and its endogenous ability to resist aggressive factors become higher.
Groprinosin syrup for children is used not only as the main drug for the correction of a certain pathology - it can be prescribed as an additional element of a multicomponent course. This is usually recommended for infection of integuments mucous with herpetic viruses. Using the composition allows you to activate the regeneration of diseased areas. A markedly higher speed is observed in comparison with the classical therapeutic approach. Studies have shown: new vesicles do not appear so often, the patient is less concerned about erosion, swelling. The use of Groprinosin reduces the frequency of exacerbations. Proper use of syrup can reduce the frequency of infection, shortens the duration of each case and reduces its severity.
Kinetics
In the instructions for use with Groprinosin syrup, the manufacturer specifies the good absorption of the drug after taking the medication. The efficiency of the assimilation process is estimated at more than 90%, which allows us to talk about almost complete absorption. Bioavailability is seen as good. With a single use of one and a half grams of inosine, the maximum concentration of this compound in the circulatory system is fixed after about an hour. On average, the parameter is 600 μg / ml. Two hours after the use of the composition, it is not possible to identify the active ingredient in the blood.
The medicine, as can be learned from the instructions for use accompanying the Groprinosin syrup, is a combined composition and includes inosine and an acid salt. Both ingredients, when found in the human body, soon transform under the influence of active substances. Almost completely, metabolic results enter urine. The elimination period is from eight hours to a full day from the moment the drug enters the body.
Kinetics: Continuing Examination
Groprinosin, produced in the form of syrup, contains inosine, which in the human body is transformed according to the cycle characteristic of purine nucleotides. The process is associated with the generation of uric acid with a possible increase in the content of this element in urine. There is a likelihood of the formation of acid crystals in the pathways of urine. The increase in the content of the compound is non-linear, in the first three hours after the use of the composition it can change by 10% up or down. No cumulative effect was found.
All the ingredients of the Groprinosin syrup are excreted from the patient’s body with urine. If you use 4 g of the drug every day, an equilibrium concentration is gradually achieved. When the condition becomes such, excretion of uric acid salts and products of its transformation is estimated at 85% of the substance ingested. The half-life is 50 minutes, the transformation products - up to five hours. A fully combined active ingredient is excreted in approximately 48 hours.
Technical Details
The drug is sold in pharmacies without a prescription. The drug is available in 150 ml vials. The tool is equipped with a syringe. For every 5 ml of the drug, 250 mg of the active ingredient is necessary. The product is made in the form of a clear solution, it has a sweetish taste. In the composition of the Groprinosin syrup, in addition to pranobex inosine (combined compound), auxiliary substances are present. The manufacturer used specially prepared pure water, sodium compounds, citric acid, as well as additives E216, E218. This composition provides the drug with a sufficiently long storage period. Due to additional components, the medicine is convenient and simple to use, which is especially important if it is necessary to choose a remedy for treating a small child.
The price of Groprinosin in pharmacies is quite high - about one and a half thousand rubles. For this amount, the buyer receives at his disposal 150 ml of medication. The drug is packaged in a container made of tinted glass. The syringe accompanying the pharmaceutical product is made of plastic. A scale is provided that allows you to measure 0.5-5 ml in one procedure.
Is it worth using?
As you can see from the relatively few responses, the price of Groprinosin scares many, so the drug is not bought very often. Those who used it, as well as used to treat children, recognized a good effect. Many, however, note: you can find compounds with a similar result of application, but at a more affordable cost. Another point that buyers pay attention to is the inaccessibility of the product. Groprinosin tablets are sold in almost any pharmacy, but finding syrup is often quite difficult.
When will it help?
All indications for the use of Groprinosin syrup are listed in the documentation accompanying the pharmaceutical product compiled by the manufacturer. The drug can be used for children over one year of age. For persons aged 1-6 years, the syrup is recommended for infection of the skin, mucous membranes with herpetic viruses of the first or second type. The drug is prescribed for a tendency to exacerbation of infection of the respiratory system against a background of weakened immunity. With this pathological condition, Groprinosin is prescribed as an additional ingredient in a multicomponent therapeutic program. A good result of the use of syrup with panencephalitis in a subacute form, accompanied by sclerotic processes, has been proven.
Groprinosin syrup manufacturer (Gideon Richter) recommends the use of a liquid drug for the treatment of children under six years of age. For persons over advised to choose pills. In a tablet form, "Groprinosin" is also indicated in the case of a weight greater than 21 kg. If necessary, pre-crush the tablet, dissolve in pure water without additives. The drug is prepared immediately before administration.
Terms of use
The pharmaceutical product is for oral use. The dosage of the Groprinosin syrup is selected, focusing on the characteristics of the course of the disease, the patient’s body weight. The volumes laid on the day must be divided into several servings equal to each other. The duration of a therapeutic program varies from five days to two weeks, although exceptional situations are possible. The drug is used while there are manifestations of a viral disease, and also for one or two days after the symptoms have subsided.
Children over the age of one year are recommended to take Groprinosin syrup in an amount of 50 mg / kg, that is, one milliliter per kilogram. The daily dose should be divided into three or four servings. To properly dose the medication, you must use the syringe supplied with the syrup.
Diagnoses and Doses
In case of skin infection, mucosal damage caused by invasion of the herpetic virus of the first or second type, Groprinosin syrup should be used from one and a half to two weeks to four times a day. Therapy lasts until the symptoms disappear.
As an auxiliary element of the therapeutic course, Groprinosin syrup with reduced activity of the immune system is prescribed for children prone to relapse of respiratory system infection. The duration of the program reaches three weeks. An alternative is three courses lasting from a week to one and a half, with pauses of equal length between sets. Syrup is used three or four times daily. If you need to adjust the state of lack of immunity, you can take "Groprinosin" from a three-week period to three times as long.
In the case of the subacute course of sclerosing panencephalitis, the syrup is prescribed six times daily. Between receptions it is necessary to observe four-hour pauses. Dose per day - 50-100 mg / kg. The duration of the program is from eight days to one and a half weeks, after which an eight-day break is required. If the disease develops in a mild form, it is necessary to additionally go from one to three courses, if the course is severe, it will take up to nine repetitions.
About the nuances
In the instructions describing the nuances of use and special instructions, the Groprinosin syrup is presented as a tool that can be prescribed not only to children and adults, but also to elderly people. For such patients, it is recommended to consume 50 mg / kg per day, that is, a milliliter per kilogram. Usually the total volume is up to three grams. This number is divided into three or four servings, between which equal temporary pauses should be observed. Maximum per day, you can take no more than 4 g of the drug.
For children under one year of age, syrup is contraindicated.
Undesirable consequences
In the manufacturer's instructions, attention is drawn to possible side effects of the Groprinosin syrup. There is a low probability of the occurrence of most body reactions. Typical unpleasant consequences are explained by a transistor increase in the content of uric acid in blood plasma, urine. A few days after the cessation of administration, the content of this substance stabilizes to normal. Some people taking the drug noted that they were sick and dizzy. Cases of increased fatigue and general malaise have been recorded. Occasionally, a craving for sleep, the inability to fall asleep, and nervousness of the person taking the medication were observed. It is known that, against the background of treatment, it can vomit and vomit. Sometimes patients complained of discomfort in the stomach. A relatively high probability of a skin reaction in the form of foci of rashes or itching. Some patients had polyuria. The risks of arthralgia are relatively high.
Is it possible or not?
For taking Groprinosin syrup, contraindications are acute gout, the presence of stones in the bladder, and severe kidney failure. The drug is not used if the blood plasma tests show a uric acid content higher than normal. Groprinosin is not used to treat children under one year of age. You can not use this drug if the high susceptibility of any ingredient of the drug is established.
Groprinosin syrup is used very carefully if the patient is shown to use drugs that activate the elimination of uric acid by the renal system. This applies to thiazide and loop diuretics. The condition of the patient, who must constantly use xanthine oxidizing inhibitory drugs, requires special attention.
No special studies have been conducted to determine how the ingredients of the pharmaceutical product in question affect the gestating fetus and the level of fertility. No events were organized to determine the inosine in the secret of the female mammary glands. During the period of gestation, during lactation, the described syrup is allowed to be used if the obvious benefit for the woman significantly exceeds the possible risks for the child.
Safety regulations
"Groprinosin" can be used only during the period when the drug is suitable. The duration of permitted storage is two years. After opening the container is allowed to use its contents for only six months. Storage conditions of Groprinosin syrup:
- a place inaccessible to children;
- warming up the medium no higher than 30 degrees Celsius.
Do not freeze the product, refrigerate in the refrigerator.
The subtleties of effective treatment
As observations of people using syrup have shown, Groprinosin can cause a transistor increase in uric acid content. This applies to both plasma and urine. Usually, growth does not exceed the upper limit of the norm. Less likely to go beyond the normal framework in men, people of advanced age. The phenomenon is explained by the catabolism of inosine, in which uric acid is generated. This reaction is considered a completely normal variant of the processing of inosine by the human body. This phenomenon is not caused by serious enzymatic malfunctions, impaired renal function due to the pharmaceutical product. With gout, stones in the bladder, hyperuricemia, with impaired renal functionality, the drug is used very carefully. Caution is required in the past. The entire period of the therapeutic course must constantly check the content of uric acid.
If Groprinosin is prescribed as a long-term program, from time to time it is necessary to check the content of the indicated acid even in the absence of the described pathological conditions. For analysis, they take both urine and blood plasma. The manufacturer recommends screening to determine hepatic and renal functionality, as well as a general blood test.
Safety and performance
Groprinosin syrup contains ingredients that can provoke an allergic response to the body. This is not only the main component, but also auxiliary, used by the manufacturer to improve the technical characteristics of the product. There is a danger of a delayed type reaction. There is also sucrose in the composition, which imposes restrictions on the intake of syrup if rare genetic, hereditary pathologies are observed. Groprinosin is not prescribed if a person has fructose intolerance or the absorption of glucose-galactose is impaired. You can not use the drug for a lack of sucrose-isomaltase. Each milliliter of pharmaceutical product contains 0.65 g of sucrose. It is necessary to take this fact into account when prescribing the drug to a person who is diagnosed with diabetes mellitus.
Groprinosin syrup has practically no effect (or does not affect at all) on the person’s ability to concentrate, to solve complex problems requiring increased attention. This applies to transport management and a variety of mechanisms.
There were no cases of overdose of a pharmaceutical product. Studies were conducted involving animals to determine the toxic qualities of the composition. The only phenomenon that was discovered was an increase in the concentration of uric acid. Based on this, it is assumed that the formation of severe consequences of an overdose is extremely unlikely.
Interaction
There is a need for careful intake of Groprinosin syrup if a person uses allopurinol or other drugs of a similar group. Combination with indapamide and the like, Furosemide and pharmaceutical products with similar qualities requires caution. If the patient uses immunosuppressants, the composition in question begins to be used only after completion of the course. Simultaneous use is prohibited.