Corinfar is a medicine that is part of the group of calcium channel blockers. The drug prevents the penetration of calcium ions into the cell membranes, helps to reduce the tone of the vascular walls, therefore it is often used with high blood pressure. The medication has an antianginal effect, due to which coronary insufficiency in ischemic disease is successfully treated. “Corinfar Uno” reviews display as an effective tool for the relief of angina attacks.
Release form, ingredients present in the composition
The drug is available in film-coated tablets. The active component, which is used as nifedipine, contains 10, 20 or 40 mg in one tablet.
Auxiliary ingredients are magnesium stearate, potato starch, povidone K25, lactose monohydrate and microcrystalline cellulose are also presented.
pharmachologic effect
The antihypertensive effect of the drug allows you to weaken and make heart contractions rarer. Such changes in the body lead to a decrease in the oxygen demand of the heart. Coronary blood flow increases after the use of Corinfar. Instructions for use, reviews show that treatment with this drug leads to positive changes in those areas of the myocardium where blood circulation is impaired.
The medication begins to act approximately twenty minutes after use, the effect obtained lasts on average five hours. About 90% of the drug penetrates the blood through the digestive tract, the maximum level of the active substance is achieved on average in three hours. The drug is characterized by high bioavailability (from 50 to 70%), the increase in which is facilitated by food intake, and communication with plasma proteins (95%). The drug of prolonged forms allows you to save the result for 24 hours.
It is known that during the treatment period the Corinfar preparation passes through natural barriers. Reviews report that the medication can penetrate the placenta and the BBB, found in breast milk. Corinfar metabolism occurs in the liver. The processes of hydrolysis and oxidation lead to the formation of inactive metabolites, most of which are excreted in the urine, the rest through the intestines with bile. 1% of the drug is not amenable to metabolic processes and passes through the kidneys unchanged. Partial elimination of the drug is carried out within two to five hours, with liver problems - longer.
Indications
The medication is prescribed for hypertension, as well as for variant angina pectoris and stable chronic angina pectoris (CHD). Indications include Raynaud's disease, colic (intestinal, biliary, and renal), bronchial obstruction syndrome, bronchial asthma (complex treatment).
Contraindications
Instructions for the drug "Corinfar", reviews report that treatment using this drug is prohibited in such cases:
- hypersensitivity to the components of the drug;
- cardiogenic shock;
- acute myocardial infarction (first 4 weeks);
- low blood pressure - hypotension, in which systolic pressure drops below 90 mm RT. st .;
- arterial stenosis (severe);
- angina pectoris (unstable) ;
- chronic heart failure (decompensation stage);
- the initial trimester when carrying a child, breastfeeding.
In cases when it is planned to carry out treatment with Corinfar medicine, reviews recommend caution when identifying such conditions:
- liver failure, renal;
- hypertension of malignant nature;
- intestinal obstruction;
- severe bradycardia, tachycardia;
- myocardial infarction (especially in cases when left ventricular failure is detected ) ;
- severe cerebrovascular accident;
- stenosis in which the mitral valve is affected;
- less than 18 years old or over 60.
At the time of treatment, you should abandon grapefruit juice, since after its use the metabolism of the active component of the drug is disrupted.
Treatment
To use "Corinfar" reviews, the instruction is recommended after a meal, without chewing and using a large amount of water. The dose of medicine is selected individually, depending on the sensitivity to the components and the patient's condition.
With angina pectoris of a vasospastic chronic form, two to three doses of a drug in a single dose of 10 mg are first prescribed. When receiving insufficient effect, an increase in the dose of the drug to 20 mg is allowed. During the day, you can not take more than 40 mg of the drug.
With essential hypertension, the average dose required to be taken in one day corresponds to two or three 10 mg tablets. You can drink one tablet at a time. A single dose can be increased to two tablets. You can not take more than four tablets per day. It is necessary to observe a minimum interval of four hours between each dose.
10 mg tablets
The recommended dosage is one tablet for daily use two to three times, if an increase in dose is required, two tablets at a frequency of administration of one to two times a day. It is forbidden to use more than 40 mg of the drug per day.
20 and 40 mg tablets
Corinfar Retard reviews and instructions recommend drinking twice a day - one or two tablets at a time.
A medicine with a dosage of 40 mg (Corinfar Uno) should be used once a day, preferably in the morning, one tablet is enough.
Side effects
Side effects that a drug with a different dosage of the main component can cause include disorders in the functioning of the cardiovascular system and the hematopoietic system, urinary system, and the functioning of the liver and gastrointestinal tract. Side effects can occur in the central nervous system, in the work of the musculoskeletal system. Allergic reactions are possible.
If collapse occurs, chest pain appears, the drug is immediately canceled. In cases where the recommended dose is exceeded, myalgia may develop, in rare cases paresthesia of the extremities was observed, vision was impaired for a while, and fatigue was present. Long-term treatment sometimes leads to the appearance of gynecomastia in the elderly, to the development of gingival hyperplasia and hyperglycemia. Other problems may be detected. Usually, for the disappearance of side effects, it is enough to discontinue the drug.
The cost of the drug, analogues
The information recommended for acquaintance is the instruction attached to the Corinfar preparation, price, reviews, analogues. You can buy medication (50 tablets) on average for 70-85 rubles.
Among the analogues of the drug are “Nicardia”, “Phenigidin”, “Nifadil”. As a substitute, Nifelat, Calcigard, Pharmadipine, or Nifedicap can be used. Perhaps treatment with the use of "Nifecard", "Cordipinum", "Adalat", "Nifebene", "Nifedipine". Structural analogues include Kordafen, Kordafleks. Nifedicor and Nifehexal are suitable for the implementation of therapy.
Reviews
If you plan to start treatment with Corinfar, the instructions, price, reviews, analogues allow you to choose the most suitable medicine. Reviews show that the medication provides a rapid decrease in blood pressure (in half an hour). The result is noticeable even after a single dose. To reduce the pressure to normal levels, the doctor must choose the most suitable dose. Usually, an increase in the dose of the drug is performed if the necessary effect is not obtained, there are no restrictions and there are no side effects. Buyers like the low price of the medicine and the effectiveness of the treatment. Side effects are not mentioned in the reviews.